The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Inhibition of Hepatic Chylomicron Remnant Uptake by Gene Transfer of a Receptor Antagonist
Abstract
The low density lipoprotein receptor-related protein (LRP) has been proposed to mediate in concert with the LDL receptor (LDLR) the uptake of dietary lipoproteins into the hepatocytes. This hypothesis was tested by transient inactivation of LRP in vivo. Receptor-associated protein (RAP), a dominant negative regulator of LRP function, was transferred by an adenoviral vector to the livers of mice lacking LDLR (LDLR -/- ). The inactivation of LRP by RAP was associated with a marked accumulation of chylomicron remnants in LDLR -/- mice and to a lesser degree in normal mice, suggesting that both LDLR and LRP are involved in remnant clearance.
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Cites
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Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E
Zhang, S. H., Reddick, R. L., Piedrahita, J. A., & Maeda, N. (1992) · Science · doi:10.1126/science.1411543 · Cited by 2,237
Carbohydrate-Specific Receptors of the Liver
Ashwell, G., & Harford, J. (1982) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.51.070182.002531 · Cited by 1,914
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Self-citationFamilial apolipoprotein E deficiency.
Schaefer, E. J., Gregg, R. E., Ghiselli, G., Forte, T. M., Ordovas, J. M., Zech, L. A., & Brewer, H. B. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112704 · Cited by 313
Windler, E. E. T., Greeve, J., Daerr, W. H., & Greten, H. (1988) · Biochemical Journal · doi:10.1042/bj2520553 · Cited by 67
Nagata, Y., Chen, J., & Cooper, A. D. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68158-x · Cited by 54
Cited by
Carr, A., Samaras, K., Chisholm, D. J., & Cooper, D. A. (1998) · The Lancet · doi:10.1016/s0140-6736(98)03391-1 · Cited by 1,065
LRP: a multifunctional scavenger and signaling receptor
Herz, J., & Strickland, D. K. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13992 · Cited by 908
Self-citationCholesterol metabolism in the brain
Dietschy, J. M., & Turley, S. D. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200104000-00003 · Cited by 906
Mahley, R. W., & Ji, Z.-S. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33334-4 · Cited by 693
Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels
Kozarsky, K. F., Donahee, M. H., Rigotti, A., Iqbal, S. N., Edelman, E. R., & Krieger, M. (1997) · Nature · doi:10.1038/387414a0 · Cited by 699
Metadata
- Authors
- Willnow, T. E., Sheng, Z., Ishibashi, S., & Herz, J.
- Venue
- Science
- Published
- 1994-06-03
- Volume
- 264
- Issue
- 5164
- Pages
- 1471-1474
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2128186576
- Cited by
- 301
- References
- 7
- FWCI
- 37.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Willnow, T. E., Sheng, Z., Ishibashi, S., & Herz, J. (1994). Inhibition of Hepatic Chylomicron Remnant Uptake by Gene Transfer of a Receptor Antagonist. Science. https://doi.org/10.1126/science.7515194
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
