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LRP: a multifunctional scavenger and signaling receptor
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Aβ binding to other LRP ligands, such as apoE, also contributes to reduced Aβ levels.
“Furthermore, A binding to other LRP ligands, such as apoE, also contributes to reduced A levels (Kang et al., 2000;Shibata et al., 2000;Herz and Strickland, 2001).”
From Increased Extracellular Amyloid Deposition and Neurodegeneration in Human Amyloid Precursor Protein Transgenic Mice Deficient in Receptor-Associated Protein (2002) · cites this paper as Herz and Strickland, 2001
LRP expressed by neurons has the capacity to signal and may be involved in LTP and in regulating synaptic plasticity.
“This is consistent with previous studies showing that LRP expressed by neurons has the capacity to signal and may be involved in long-term potentiation (LTP) and in regulating synaptic plasticity (Herz and Strickland, 2001).”
From Increased Extracellular Amyloid Deposition and Neurodegeneration in Human Amyloid Precursor Protein Transgenic Mice Deficient in Receptor-Associated Protein (2002) · cites this paper as Herz and Strickland, 2001
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Shibata, M., Yamada, S., Kumar, S. R., Calero, M., Bading, J., Frangione, B., Holtzman, D. M., Miller, C. A., Strickland, D. K., Ghiso, J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10498 · Cited by 1,413
Self-citationRohlmann, A., Gotthardt, M., Hammer, R. E., & Herz, J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1240 · Cited by 455 · cited 1×
“Clearance of Alzheimer’s amyloid-β(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.”
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The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2
Stockinger, W., Brandes, C., Fasching, D., Hermann, M., Gotthardt, M., Herz, J., Schneider, W. J., & Nimpf, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004119200 · Cited by 239 · cited 2×
“Clearance of Alzheimer’s amyloid-β(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.”
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“LRP-1 acts as a scavenger receptor to facilitate the endocytosis of its several ligands and as a signaling receptor to influence intracellular signal transduction [38, 39].”
Metadata
- Authors
- Herz, J., & Strickland, D. K.
- Venue
- Journal of Clinical Investigation
- Published
- 2001-09-15
- Volume
- 108
- Issue
- 6
- Pages
- 779-784
- ISSN
- 0021-9738
- Cited by
- 908
- References
- 4
- Language
- en
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