The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Resetting the Biological Clock: Mediation of Nocturnal Circadian Shifts by Glutamate and NO
Abstract
Circadian rhythms of mammals are timed by an endogenous clock with a period of about 24 hours located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Light synchronizes this clock to the external environment by daily adjustments in the phase of the circadian oscillation. The mechanism has been thought to involve the release of excitatory amino acids from retinal afferents to the SCN. Brief treatment of rat SCN in vitro with glutamate (Glu), N -methyl-D-aspartate (NMDA), or nitric oxide (NO) generators produced lightlike phase shifts of circadian rhythms. The SCN exhibited calcium-dependent nitric oxide synthase (NOS) activity. Antagonists of NMDA or NOS pathways blocked Glu effects in vitro, and intracerebroventricular injection of a NOS inhibitor in vivo blocked the light-induced resetting of behavioral rhythms. Together, these data indicate that Glu release, NMDA receptor activation, NOS stimulation, and NO production link light activation of the retina to cellular changes within the SCN mediating the phase resetting of the biological clock.
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Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Glutamate immunoreactivity in terminals of the retinohypothalamic tract of the brown norwegian rat
de Vries, M. J., Cardozo, B. N., van der Want, J., de Wolf, A., & Meijer, J. H. (1993) · Brain Research · doi:10.1016/0006-8993(93)91665-f · Cited by 128
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Zeitzer, J. M., Dijk, D., Kronauer, R. E., Brown, E. N., & Czeisler, C. A. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00695.x · Cited by 1,175
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Wulff, K., Gatti, S., Wettstein, J. G., & Foster, R. G. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2868 · Cited by 1,055
The Neurobiology of Sleep: Genetics, cellular physiology and subcortical networks
Pace-Schott, E. F., & Hobson, J. A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn895 · Cited by 937
A Differential Response of Two Putative Mammalian Circadian Regulators, mper1and mper2, to Light
Albrecht, U., Sun, Z. S., Eichele, G., & Lee, C. C. (1997) · Cell · doi:10.1016/s0092-8674(00)80495-x · Cited by 879
Metadata
- Authors
- Ding, J. M., Chen, D., Weber, E. T., Faiman, L. E., Rea, M. A., & Gillette, M. U.
- Venue
- Science
- Published
- 1994-12-09
- Volume
- 266
- Issue
- 5191
- Pages
- 1713-1717
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1992182952
- Cited by
- 564
- References
- 2
- FWCI
- 15.61
- Type
- journal article
- Language
- en
- Open access
- closed
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