A Differential Response of Two Putative Mammalian Circadian Regulators, mper1and mper2, to Light
Open accessAbstract
A mouse gene, mper1, having all the properties expected of a circadian clock gene, was reported recently. This gene is expressed in a circadian pattern in the suprachiasmatic nucleus (SCN). mper1 maintains this pattern of circadian expression in constant darkness and can be entrained to a new light/dark cycle. Here we report the isolation of a second mammalian gene, mper2, which also has these properties and greater homology to Drosophila period. Expression of mper1 and mper2 is overlapping but asynchronous by 4 hr. mper1, unlike period and mper2, is expressed rapidly after exposure to light at CT22. It appears that mper1 is the pacemaker component which responds to light and thus mediates photic entrainment.
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Light exposure during the night phase shifts the clock transcription-translation cycle by rapidly inducing expression of Per1 or Per2, depending on whether the light occurs during the early or late night.
“Light exposure during the night phase shifts the clock transcription-translations cycle by rapidly inducing expression of Per1 or Per2, depending on whether the light occurs during the early or late night42–44.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [42]
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- Authors
- Albrecht, U., Sun, Z. S., Eichele, G., & Lee, C. C.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Lee, Cheng Chi
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-12
- Volume
- 91
- Issue
- 7
- Pages
- 1055-1064
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2151468131
- Cited by
- 879
- References
- 46
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 15 · 2023: 14 · 2022: 16 · 2021: 27 · 2020: 17 · 2019: 20 · 2018: 16 · 2017: 27 · 2016: 27 · 2015: 22 · 2014: 29 · 2013: 28 · 2012: 26
- FWCI
- 15.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- mPer1, mPer2, clock genes, light entrainment, suprachiasmatic nucleus, light response, circadian pacemaker
- MeSH terms
- Amino Acid Sequence, Animals, Circadian Rhythm, Light, Male, Mice, Inbred C57BL, Molecular Sequence Data, Nuclear Proteins, Transcription Factors, Gene Expression, DNA, Complementary, Cell Cycle Proteins, Mice, Period Circadian Proteins
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