The DOI matches its Crossref record.
In Vivo Transfer of GPI-Linked Complement Restriction Factors from Erythrocytes to the Endothelium
Abstract
Many proteins are associated with the outer layer of the cell membrane through a posttranslationally added glycosyl phosphatidylinositol (GPI) anchor. The functional significance of this type of protein linkage is unclear, although it results in increased lateral mobility, sorting to the apical surface of the cell, reinsertion into cell membranes, and possibly cell signaling. Here evidence is presented that GPI-linked proteins can undergo intermembrane transfer in vivo. GPI-linked proteins expressed on the surface of transgenic mouse red blood cells were transferred in a functional form to endothelial cells in vivo. This feature of GPI linkage may be potentially useful for the delivery of therapeutic proteins to vascular endothelium.
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Cited by
Hill, A., Butterworth, R., Joiner, S., Jackson, G., Rossor, M., Thomas, D., Frosh, A., Tolley, N., Bell, J., Spencer, M., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)12075-5 · Cited by 699
The Glycosylphosphatidylinositol Anchor: A Complex Membrane-Anchoring Structure for Proteins
Paulick, M. G., & Bertozzi, C. R. (2008) · Biochemistry · doi:10.1021/bi8006324 · Cited by 600
Mallucci, G. R., Ratté, S., Asante, E. A., Linehan, J., Gowland, I., Jefferys, J. G. R., & Collinge, J. (2002) · The EMBO Journal · doi:10.1093/emboj/21.3.202 · Cited by 393
Jeong, S. Y., & David, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301988200 · Cited by 377
Byrne, G. W., McCurry, K. R., Martin, M. J., McClellan, S. M., Platt, J. L., & Logan, J. S. (1997) · Transplantation · doi:10.1097/00007890-199701150-00027 · Cited by 311
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Metadata
- Authors
- Kooyman, D. L., Byrne, G. W., McClellan, S., Nielsen, D., Tone, M., Waldmann, H., Coffman, T. M., McCurry, K. R., Platt, J. L., & Logan, J. S.
- Venue
- Science
- Published
- 1995-07-07
- Volume
- 269
- Issue
- 5220
- Pages
- 89-92
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1976863839
- Cited by
- 250
- References
- 0
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: In Vivo Transfer of GPI-Linked Complement Restriction Factors from Erythrocytes to the Endothelium. https://app.cochat.ai/papers/10.1126/science.7541557
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- Kooyman, D. L., Byrne, G. W., McClellan, S., Nielsen, D., Tone, M., Waldmann, H., Coffman, T. M., McCurry, K. R., Platt, J. L., & Logan, J. S. (1995). In Vivo Transfer of GPI-Linked Complement Restriction Factors from Erythrocytes to the Endothelium. Science. https://doi.org/10.1126/science.7541557
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
