The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
The Glycosylphosphatidylinositol Anchor: A Complex Membrane-Anchoring Structure for Proteins
Open accessAbstract
Positioned at the C-terminus of many eukaryotic proteins, the glycosylphosphatidylinositol (GPI) anchor is a posttranslational modification that anchors the modified protein in the outer leaflet of the cell membrane. The GPI anchor is a complex structure comprising a phosphoethanolamine linker, glycan core, and phospholipid tail. GPI-anchored proteins are structurally and functionally diverse and play vital roles in numerous biological processes. While several GPI-anchored proteins have been characterized, the biological functions of the GPI anchor have yet to be elucidated at a molecular level. This review discusses the structural diversity of the GPI anchor and its putative cellular functions, including involvement in lipid raft partitioning, signal transduction, targeting to the apical membrane, and prion disease pathogenesis. We specifically highlight studies in which chemically synthesized GPI anchors and analogues have been employed to study the roles of this unique posttranslational modification.
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Cites
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Nanoscale Organization of Multiple GPI-Anchored Proteins in Living Cell Membranes
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Anchorless Prion Protein Results in Infectious Amyloid Disease Without Clinical Scrapie
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Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development
Baenke, F., Peck, B., Miess, H., & Schulze, A. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.011338 · Cited by 772
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Cummings, R. D. (2009) · Molecular BioSystems · doi:10.1039/b907931a · Cited by 487
Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies
Revesz, T., Holton, J. L., Lashley, T., Plant, G., Frangione, B., Rostagno, A., & Ghiso, J. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0501-8 · Cited by 294
Bitter-sweet symphony: glycan–lectin interactions in virus biology
Van Breedam, W., Pöhlmann, S., Favoreel, H. W., de Groot, R. J., & Nauwynck, H. J. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12052 · Cited by 141
Metadata
- Authors
- Paulick, M. G., & Bertozzi, C. R.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-06-17
- Volume
- 47
- Issue
- 27
- Pages
- 6991-7000
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2050606799
- Cited by
- 600
- References
- 50
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
