The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
CD1-Restricted T Cell Recognition of Microbial Lipoglycan Antigens
Abstract
It has long been the paradigm that T cells recognize peptide antigens presented by major histocompatibility complex (MHC) molecules. However, nonpeptide antigens can be presented to T cells by human CD1b molecules, which are not encoded by the MHC. A major class of microbial antigens associated with pathogenicity are lipoglycans. It is shown here that human CD1b presents the defined mycobacterial lipoglycan lipoarabinomannan (LAM) to αβ T cell receptor-bearing lymphocytes. Presentation of these lipoglycan antigens required internalization and endosomal acidification. The T cell recognition required mannosides with α(1→2) linkages and a phosphatidylinositol unit. T cells activated by LAM produced interferon γ and were cytolytic. Thus, an important class of microbial molecules, the lipoglycans, is a part of the universe of foreign antigens recognized by human T cells.
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Haurum, J. S., Arsequell, G., Lellouch, A. C., Wong, S. Y., Dwek, R. A., McMichael, A. J., & Elliott, T. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.2.739 · Cited by 184
Cited by
CD1d-Restricted and TCR-Mediated Activation of V α 14 NKT Cells by Glycosylceramides
Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Motoki, K., Ueno, H., Nakagawa, R., Sato, H., Kondo, E., et al. (1997) · Science · doi:10.1126/science.278.5343.1626 · Cited by 2,400
Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis
Schaible, U. E., Winau, F., Sieling, P. A., Fischer, K., Collins, H. L., Hagens, K., Modlin, R. L., Brinkmann, V., & Kaufmann, S. H. E. (2003) · Nature Medicine · doi:10.1038/nm906 · Cited by 546
Self-citationDoherty, D. G., Norris, S., Madrigal-Estebas, L., McEntee, G., Traynor, O., Hegarty, J. E., & O’Farrelly, C. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.2314 · Cited by 350
Prigozy, T. I., Sieling, P. A., Clemens, D., Stewart, P. L., Behar, S. M., Porcelli, S. A., Brenner, M. B., Modlin, R. L., & Kronenberg, M. (1997) · Immunity · doi:10.1016/s1074-7613(00)80425-2 · Cited by 337
Self-citationBurdin, N., Brossay, L., Koezuka, Y., Smiley, S. T., Grusby, M. J., Gui, M., Taniguchi, M., Hayakawa, K., & Kronenberg, M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3271 · Cited by 334
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Metadata
- Authors
- Sieling, P. A., Chatterjee, D., Porcelli, S. A., Prigozy, T. I., Mazzaccaro, R. J., Soriano, T., Bloom, B. R., Brenner, M. B., Kronenberg, M., Brennan, P. J., & Modlin, R. L.
- Venue
- Science
- Published
- 1995-07-14
- Volume
- 269
- Issue
- 5221
- Pages
- 227-230
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2027679419
- Cited by
- 740
- References
- 1
- FWCI
- 24.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sieling, P. A., Chatterjee, D., Porcelli, S. A., Prigozy, T. I., Mazzaccaro, R. J., Soriano, T., Bloom, B. R., Brenner, M. B., Kronenberg, M., Brennan, P. J., & Modlin, R. L. (1995). CD1-Restricted T Cell Recognition of Microbial Lipoglycan Antigens. Science. https://doi.org/10.1126/science.7542404
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