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The lymphoid liver: Considerations on pathways to autoimmune injury

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Selective Loss of Innate CD4+Vα24 Natural Killer T Cells in Human Immunodeficiency Virus Infection

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Immunology of the healthy liver: Old questions and new insights

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Role of primary intrahepatic T‐cell activation in the ‘liver tolerance effect’

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Hepatic Natural Killer Cells: Organ-Specific Sentinels of Liver Immune Homeostasis and Physiopathology

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Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure

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To be or not to be NKT: Natural killer T cells in the liver

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NK cells, displaying early activation, cytotoxicity and adhesion molecules, are associated with mild dengue disease

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Distinct subpopulations of γδ T cells are present in normal and tumor-bearing human liver

Kenna, T., Golden‐Mason, L., Norris, S., Hegarty, J. E., O’Farrelly, C., & Doherty, D. G. (2004) · Clinical Immunology · doi:10.1016/j.clim.2004.05.003 · Cited by 139 · see citing works

Cytokine-induced killer cells are terminallydifferentiated activated CD8 cytotoxic T-EMRA lymphocytes

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Tissue‐resident Eomeshi T‐betlo CD56bright NK cells with reduced proinflammatory potential are enriched in the adult human liver

Harmon, C., Robinson, M. W., Fahey, R., Whelan, S., Houlihan, D. D., Geoghegan, J., & O’Farrelly, C. (2016) · European Journal of Immunology · doi:10.1002/eji.201646559 · Cited by 140 · see citing works

Drug-induced liver injury: Is it somehow foreseeable?

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Chemokines in the immunopathogenesis of hepatitis C infection #

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Hepatic CD1d Expression in Hepatitis C Virus Infection and Recognition by Resident Proinflammatory CD1d-Reactive T Cells

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Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-α during alcohol consumption

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Up-regulation of Inhibitory Natural Killer Receptors CD94/NKG2A with Suppressed Intracellular Perforin Expression of Tumor-Infiltrating CD8+ T Lymphocytes in Human Cervical Carcinoma

Sheu, B., Chiou, S., Lin, H., Chow, S., Huang, S., Ho, H., & Hsu, S.-M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2108 · Cited by 130 · see citing works

Reduced frequencies of NKp30+NKp46+, CD161+, and NKG2D+ NK cells in acute HCV infection may predict viral clearance

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Untitled work

(2001) · doi:10.1002/1521-4141(200108)31:8

Incidence and characteristics of CD4(+)/HLA DRhi dendritic cell malignancies.

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Compromised Function of Natural Killer Cells in Acute and Chronic Viral Hepatitis

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Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus

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Increased Natural Killer Cell Cytotoxicity and NKp30 Expression Protects Against Hepatitis C Virus Infection in High-Risk Individuals and Inhibits Replication In Vitro

Golden‐Mason, L., Cox, A. L., Randall, J. A., Cheng, L., & Rosen, H. R. (2010) · Hepatology · doi:10.1002/hep.23896 · Cited by 117 · see citing works

The immune niche of the liver

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NK Cells: A Double-Edged Sword in Chronic Hepatitis B Virus Infection

Maini, M. K., & Peppa, D. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00057 · Cited by 109 · see citing works

Activation-Induced Expression of CD56 by T Cells Is Associated With a Reprogramming of Cytolytic Activity and Cytokine Secretion Profile In Vitro

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Activating Immunity in the Liver. I. Liver Dendritic Cells (but Not Hepatocytes) Are Potent Activators of IFN-γ Release by Liver NKT Cells

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Natural killer T (NKT) cells and their role in antitumor immunity

Brutkiewicz, R. R., & Sriram, V. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00198-6 · Cited by 105 · see citing works

Frequency and Phenotype of Circulating Vα24/Vβ11 Double-Positive Natural Killer T Cells during Hepatitis C Virus Infection

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Aged garlic extract supplementation modifies inflammation and immunity of adults with obesity: A randomized, double-blind, placebo-controlled clinical trial

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IL-15 induces CD8+ T cells to acquire functional NK receptors capable of modulating cytotoxicity and cytokine secretion

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Role of NK and NKT cells in the immunopathogenesis of HCV-induced hepatitis

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Double-Blinded, Randomized Phase II Study Using Embolization with or without Granulocyte–Macrophage Colony-Stimulating Factor in Uveal Melanoma with Hepatic Metastases

Valsecchi, M. E., Terai, M., Eschelman, D. J., Gonsalves, C. F., Chervoneva, I., Shields, J. A., Shields, C. L., Yamamoto, A., Sullivan, K. L., Laudadio, M., et al. (2015) · Journal of Vascular and Interventional Radiology · doi:10.1016/j.jvir.2014.11.037 · Cited by 98 · see citing works

Liver-infiltrating lymphocytes in end-stage hepatitis C virus: Subsets, activation status, and chemokine receptor phenotypes

Boisvert, J., Kunkel, E. J., Campbell, J. J., Keeffe, E. B., Butcher, E. C., & Greenberg, H. B. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00328-8 · Cited by 98 · see citing works

Decrease in hepatic CD56+ T cells and Vα24+ natural killer T cells in chronic hepatitis C viral infection

Deignan, T., Curry, M. P., Doherty, D. G., Golden‐Mason, L., Volkov, Y., Norris, S., Nolan, N. P., Traynor, O., McEntee, G., Hegarty, J. E., et al. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00072-7 · Cited by 98 · see citing works

Immunomodulatory Effects of the Liver: Deletion of Activated CD4+ Effector Cells and Suppression of IFN-γ-Producing Cells After Intravenous Protein Immunization1

Klugewitz, K., Blumenthal-Barby, F., Schrage, A., Knolle, P., Hamann, A., & Crispe, I. (2002) · Journal of Immunology · doi:10.4049/jimmunol.169.5.2407 · Cited by 108 · see citing works

IL-15 Overcomes Hepatocellular Carcinoma-Induced NK Cell Dysfunction

Easom, N. J. W., Stegmann, K. A., Swadling, L., Pallett, L. J., Burton, A. R., Odera, D., Schmidt, N. M., Huang, W., Fusai, G., Davidson, B. R., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01009 · Cited by 96 · see citing works

Decrease in CD3-negative-CD8dim+ and Vδ2/Vγ9 TcR+ peripheral blood lymphocyte counts, low perforin expression and the impairment of natural killer cell activity is associated with chronic hepatitis C virus infection

Pár, G., Rukavina, D., Podack, E. R., Horányi, M., Szekeres‐Barthó, J., Hegedűs, G., Paál, M., Szereday, L., Mózsik, G., & Pár, A. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00218-0 · Cited by 92 · see citing works

Adoptive immunotherapy with liver allograft–derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice

Ohira, M., Ishiyama, K., Tanaka, Y., Doskali, M., Igarashi, Y., Tashiro, H., Hiraga, N., Imamura, M., Sakamoto, N., Asahara, T., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38374 · Cited by 91 · see citing works

Cells with haematopoietic stem cell phenotype in adult human endometrium: relevance to infertility?

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Liver Grafts Contain a Unique Subset of Natural Killer Cells That Are Transferred Into the Recipient After Liver Transplantation

Moroso, V., Metselaar, H. J., Mancham, S., Tilanus, H. W., Eissens, D., van der Meer, A., van der Laan, L. J. W., Kuipers, E. J., Joosten, I., & Kwekkeboom, J. (2010) · Liver Transplantation · doi:10.1002/lt.22080 · Cited by 88 · see citing works

3D Porous Chitosan–Alginate Scaffolds: A New Matrix for Studying Prostate Cancer Cell–Lymphocyte Interactions In Vitro

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Unique Aspects of Rejection and Tolerance in Liver Transplantation

Knechtle, S. J., & Kwun, J. (2009) · Seminars in Liver Disease · doi:10.1055/s-0029-1192058 · Cited by 85 · see citing works

Immunopathogenesis of hepatitis C virus infection

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Immunomodulation of human natural killer cell cytotoxic function by triazine and carbamate pesticides

Whalen, M. M., Loganathan, B. G., Yamashita, N., & Saito, T. (2003) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(03)00027-9 · Cited by 84 · see citing works

Differentiation of human innate lymphoid cells (ILCs)

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Increased Infiltration of Natural Killer and T Cells in Colorectal Liver Metastases Improves Patient Overall Survival

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The role of natural killer cells in autoimmune liver disease: A comprehensive review

Hudspeth, K. L., Pontarini, E., Tentorio, P., Cimino, M., Donadon, M., Torzilli, G., Lugli, E., Bella, S. D., Gershwin, M. E., & Mavilio, D. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.07.003 · Cited by 80 · see citing works

Are increased frequency of macrophage-like and natural killer (NK) cells, together with high levels of NKT and CD4+CD25high T cells balancing activated CD8+ T cells, the key to control Chagas’ disease morbidity?

Vitelli-Avelar, D. M., Sathler-Avelar, R., Massara, R. L., BORGES, J. D. M., Lage, P. S., de Lana, M., Teixeira‐Carvalho, A., Dias, J. C. P., Elói-Santos, S. M., & Martins‐Filho, O. A. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03123.x · Cited by 80 · see citing works

Murine CD146 is widely expressed on endothelial cells and is recognized by the monoclonal antibody ME-9F1

Schrage, A., Loddenkemper, C., Erben, U., Lauer, U., Hausdorf, G., Jungblut, P. R., Johnson, J. P., Knolle, P. A., Zeitz, M., Hamann, A., et al. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0379-x · Cited by 76 · see citing works

Diverse populations of T cells with NK cell receptors accumulate in the human intestine in health and in colorectal cancer

O’Keeffe, J., Doherty, D. G., Kenna, T., Sheahan, K. D., O’Donoghue, D. P., Hyland, J. M., & O’Farrelly, C. (2004) · European Journal of Immunology · doi:10.1002/eji.200424958 · Cited by 77 · see citing works

Natural Killer T-like Cells: Immunobiology and Role in Disease

Almeida, J. S., Casanova, J., Santos-Rosa, M., Tarazona, R., Solana, R., & Rodrigues‐Santos, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032743 · Cited by 75 · see citing works

Activating NK cell receptor expression/function (NKp30, NKp46, DNAM‐1) during chronic viraemic HCV infection is associated with the outcome of combined treatment

Bozzano, F. M., Picciotto, A., Costa, P., Marras, F., Fazio, V., Hirsch, I., Olive, D., Moretta, L., & Maria, A. D. (2011) · European Journal of Immunology · doi:10.1002/eji.201041361 · Cited by 75 · see citing works

CD1d‐mediated stimulation of natural killer T cells selectively activates hepatic natural killer cells to eliminate experimentally disseminated hepatoma cells in murine liver

Miyagi, T., Takehara, T., Tatsumi, T., Kanto, T., Suzuki, T., Jinushi, M., Sugimoto, Y., Sasaki, Y., Hori, M., & Hayashi, N. (2003) · International Journal of Cancer · doi:10.1002/ijc.11163 · Cited by 74 · see citing works

CD8+CD28– T cells: Certainties and uncertainties of a prevalent human T‐cell subset

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Donor HLA-C Genotype Has a Profound Impact on the Clinical Outcome Following Liver Transplantation

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Chemokines in hepatitis C virus infection: Pathogenesis, prognosis and therapeutics

Wald, O., Weiss, I. D., Galun, E., & Peled, A. (2007) · Cytokine · doi:10.1016/j.cyto.2007.05.013 · Cited by 71 · see citing works

The Dynamic Role of NK Cells in Liver Cancers: Role in HCC and HBV Associated HCC and Its Therapeutic Implications

Sajid, M., Liu, L., & Sun, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.887186 · Cited by 71 · see citing works

Cellular Immune Responses against Hepatitis C Virus

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Immunology of the gut and liver: a love/hate relationship

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Changes in leucocyte and lymphocyte subsets during tuberculosis treatment; prominence of CD3dimCD56+ natural killer T cells in fast treatment responders

Veenstra, H., Baumann, R., Carroll, N. M., Lukey, P. T., Kidd, M., Beyers, N., Bolliger, C. T., van Helden, P. D., & Walzl, G. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03144.x · Cited by 70 · see citing works

NK cells can generate from precursors in the adult human liver

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Clinical features of COVID‐19 convalescent patients with re‐positive nucleic acid detection

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Regulation of antitumour immunity by CD1d-restricted NKT cells

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CD3 + CD56 + NK T cells are significantly decreased in the peripheral blood of patients with psoriasis

Koreck, A., Surányi, A., Szóny, B. J., Farkas, Á., Bata‐Csörgõ, Z., Kemény, L. V., & DOBOZY, A. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.01721.x · Cited by 65 · see citing works

Reduced CD4+ subset and Th1 bias of the human iNKT cells in Type 1 diabetes mellitus

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The Crosstalk between Tumor Cells and the Microenvironment in Hepatocellular Carcinoma: The Role of Exosomal microRNAs and Their Clinical Implications

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Safety and immunogenicity of therapeutic DNA vaccine with antiviral drug in chronic HBV patients and its immunogenicity in mice

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Augmented hepatic interferon gamma expression and T-cell influx characterize acute hepatitis progressing to recovery and residual lifelong virus persistence in experimental adult woodchuck hepatitis virus infection

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Basic concepts in transplant immunology

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Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Vα24-JαQ and γδ T cell receptor bearing cells

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A high proportion of T cells in the adult human liver express natural killer (NK) cell phenotypes and exhibit NK function

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Tissue‐resident Eomeshi T‐betlo CD56bright NK cells with reduced proinflammatory potential are enriched in the adult human liver

Harmon, C., Robinson, M. W., Fahey, R., Whelan, S., Houlihan, D. D., Geoghegan, J., & O’Farrelly, C. (2016) · European Journal of Immunology · doi:10.1002/eji.201646559 · Cited by 140 · see citing works

Investigating the phenotype and functional roles of human liver-resident natural killer (NK) cells

Jameson, G. (2021) · Arrow@dit (Dublin Institute of Technology)

To be or not to be NKT: Natural killer T cells in the liver

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