The DOI matches its Crossref record.
Sensing Starvation: a Homoserine Lactone—Dependent Signaling Pathway in Escherichia coli
Abstract
When nutrients become limiting, many bacteria differentiate and become resistant to environmental stresses. For Escherichia coli , this process is mediated by the σ s subunit of RNA polymerase. Expression of σ s was induced by homoserine lactone, a metabolite synthesized from intermediates in threonine biosynthesis. Homoserine lactone-dependent synthesis of σ s was prevented by overexpression of a newly identified protein, RspA. The function of homoserine lactone derivatives in many cell density-dependent phenomena and the similarity of RspA to a Streptomyces ambofaciens protein suggest that synthesis of homoserine lactone may be a general signal of starvation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Hengge-Aronis, R. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.3.373-395.2002 · Cited by 936
Thinking about Bacterial Populations as Multicellular Organisms
Shapiro, J. A. (1998) · Annual Review of Microbiology · doi:10.1146/annurev.micro.52.1.81 · Cited by 876
Latifi, A., Foglino, M., Tanaka, K., Williams, P., & Lazdunski, A. (1996) · Molecular Microbiology · doi:10.1046/j.1365-2958.1996.00063.x · Cited by 716
Quorum sensing in Escherichia coli and Salmonella typhimurium
Surette, M. G., & Bassler, B. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.7046 · Cited by 640
Functional Modulation of Escherichia Coli RNA Polymerase
Ishihama, A. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.499 · Cited by 599
Metadata
- Authors
- Huisman, G. W., & Kolter, R.
- Venue
- Science
- Published
- 1994-07-22
- Volume
- 265
- Issue
- 5171
- Pages
- 537-539
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059572695
- Cited by
- 217
- References
- 0
- FWCI
- 13.07
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Sensing Starvation: a Homoserine Lactone—Dependent Signaling Pathway in Escherichia coli. https://app.cochat.ai/papers/10.1126/science.7545940
- The paper
- Huisman, G. W., & Kolter, R. (1994). Sensing Starvation: a Homoserine Lactone—Dependent Signaling Pathway in Escherichia coli. Science. https://doi.org/10.1126/science.7545940
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
