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Imaging Elementary Events of Calcium Release in Skeletal Muscle Cells
Abstract
In skeletal muscle cells, calcium release to trigger contraction occurs at triads, specialized junctions where sarcoplasmic reticulum channels are opened by voltage sensors in the transverse tubule. Scanning confocal microscopy was used in cells under voltage clamp to measure the concentration of intracellular calcium, [Ca 2+ ] i , at individual triads and [Ca 2+ ] i gradients that were proportional to calcium release. In cells stimulated with small depolarizations, the [Ca 2+ ] i gradients broke down into elementary events, corresponding to single-channel currents of about 0.1 picoampere. Because these events were one-tenth to one-fifth the size of calcium sparks (elementary release events of cardiac muscle), skeletal muscle control mechanisms appear to be fundamentally different.
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Citations
Cited by
Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences
Rizzuto, R., & Pozzan, T. (2006) · Physiological Reviews · doi:10.1152/physrev.00004.2005 · Cited by 1,206
Elementary and global aspects of calcium signalling.
Berridge, M. J. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp021927 · Cited by 1,018
Shape, Size, and Distribution of Ca2+ Release Units and Couplons in Skeletal and Cardiac Muscles
Franzini-Armstrong, C., Protasi, F., & Ramesh, V. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77000-1 · Cited by 572
The elemental principles of calcium signaling
Bootman, M. D., & Berridge, M. J. (1995) · Cell · doi:10.1016/0092-8674(95)90179-5 · Cited by 454
Modulation of the Ryanodine Receptor and Intracellular Calcium
Zalk, R., Lehnart, S. E., & Marks, A. R. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.053105.094237 · Cited by 371
Metadata
- Authors
- Tsugorka, A., Ríos, E., & Blatter, L. A.
- Venue
- Science
- Published
- 1995-09-22
- Volume
- 269
- Issue
- 5231
- Pages
- 1723-1726
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2002741066
- Cited by
- 282
- References
- 0
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- closed
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