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GTBP, a 160-Kilodalton Protein Essential for Mismatch-binding Activity in Human Cells
Open accessAbstract
DNA mismatch recognition and binding in human cells has been thought to be mediated by the hMSH2 protein. Here it is shown that the mismatch-binding factor consists of two distinct proteins, the 100-kilodalton hMSH2 and a 160-kilodalton polypeptide, GTBP (for G/T binding protein). Sequence analysis identified GTBP as a new member of the MutS homolog family. Both proteins are required for mismatch-specific binding, a result consistent with the finding that tumor-derived cell lines devoid of either protein are also devoid of mismatch-binding activity.
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Citations
Cited by
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
Microsatellite Instability in Colorectal Cancer
Boland, C. R., & Goel, A. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.064 · Cited by 2,456
Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells
Drummond, J. T., Li, G.-M., Longley, M. J., & Modrich, P. (1995) · Science · doi:10.1126/science.7604264 · Cited by 601
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair
Marsischky, G. T., Filosi, N., Kane, M. F., & Kolodner, R. (1996) · Genes & Development · doi:10.1101/gad.10.4.407 · Cited by 581
hMutSβ, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA
Palombo, F., Iaccarino, I., Nakajima, E., Ikejima, M., Shimada, T., & Jiricny, J. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70685-4 · Cited by 371
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Metadata
- Authors
- Palombo, F., Gallinari, P., Iaccarino, I., Lettieri, T., Hughes, M., D'Arrigo, A., Truong, O., Hsuan, J. J., & Jiricny, J.
- Venue
- Science
- Published
- 1995-06-30
- Volume
- 268
- Issue
- 5219
- Pages
- 1912-1914
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012867725
- Cited by
- 524
- References
- 0
- FWCI
- 22.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Palombo, F., Gallinari, P., Iaccarino, I., Lettieri, T., Hughes, M., D'Arrigo, A., Truong, O., Hsuan, J. J., & Jiricny, J. (1995). GTBP, a 160-Kilodalton Protein Essential for Mismatch-binding Activity in Human Cells. Science. https://doi.org/10.1126/science.7604265
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