The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells
Abstract
A mismatch-binding heterodimer of hMSH2 and a 160-kilodalton polypeptide has been isolated from HeLa cells by virtue of its ability to restore mismatch repair to nuclear extracts of hMSH2-deficient LoVo colorectal tumor cells. This heterodimer, designated hMutSα, also restores mismatch repair to extracts of alkylation-tolerant MT1 lymphoblastoid cells and HCT-15 colorectal tumor cells, which are selectively defective in the repair of base-base and single-nucleotide insertion-deletion mismatches. Because HCT-15 cells appear to be free of hMSH2 mutations, this selective repair defect is likely a result of a deficiency of the hMutSα 160-kilodalton subunit, and mutations in the corresponding gene may confer hypermutability and cancer predisposition.
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Cites
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
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Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
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Mutation of a mutL Homolog in Hereditary Colon Cancer
Papadopoulos, N., Nicolaides, N. C., Wei, Y.-F., Ruben, S. M., Carter, K. C., Rosen, C. A., Haseltine, W. A., Fleischmann, R. D., Fraser, C. M., Adams, M. D., et al. (1994) · Science · doi:10.1126/science.8128251 · Cited by 1,834
Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer
Nicolaides, N. C., Papadopoulos, N., Liu, B., Weit, Y.-F., Carter, K. C., Ruben, S. M., Rosen, C. A., Haseltine, W. A., Fleischmann, R. D., Fraser, C. M., et al. (1994) · Nature · doi:10.1038/371075a0 · Cited by 1,545
Hypermutability and mismatch repair deficiency in RER+ tumor cells
Parsons, R., Li, G.-M., Longley, M. J., Fang, W.-H., Papadopoulos, N., Jen, J., de la Chapelle, A., Kinzler, K. W., Vogelstein, B., & Modrich, P. (1993) · Cell · doi:10.1016/0092-8674(93)90331-j · Cited by 1,053
Self-citationMicrosatellite instability: marker of a mutator phenotype in cancer.
Loeb, L. A. (1994) · PubMed · Cited by 546
GTBP, a 160-Kilodalton Protein Essential for Mismatch-binding Activity in Human Cells
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Cited by
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair
Marsischky, G. T., Filosi, N., Kane, M. F., & Kolodner, R. (1996) · Genes & Development · doi:10.1101/gad.10.4.407 · Cited by 581
Buermeyer, A. B., Deschênes, S. M., Baker, S. M., & Liskay, R. M. (1999) · Annual Review of Genetics · doi:10.1146/annurev.genet.33.1.533 · Cited by 451
hMutSβ, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA
Palombo, F., Iaccarino, I., Nakajima, E., Ikejima, M., Shimada, T., & Jiricny, J. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70685-4 · Cited by 371
Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis
de Vries, S. S., Baart, E. B., Dekker, M., Siezen, A., de Rooij, D. G., de Boer, P., & te Riele, H. (1999) · Genes & Development · doi:10.1101/gad.13.5.523 · Cited by 365
Arnold, C. N., Goel, A., & Boland, C. R. (2003) · International Journal of Cancer · doi:10.1002/ijc.11176 · Cited by 280
Metadata
- Authors
- Drummond, J. T., Li, G.-M., Longley, M. J., & Modrich, P.
- Venue
- Science
- Published
- 1995-06-30
- Volume
- 268
- Issue
- 5219
- Pages
- 1909-1912
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2064700784
- Cited by
- 601
- References
- 30
- FWCI
- 21.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Drummond, J. T., Li, G.-M., Longley, M. J., & Modrich, P. (1995). Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells. Science. https://doi.org/10.1126/science.7604264
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
