The DOI matches its Crossref record.
Mutations of GTBP in Genetically Unstable Cells
Abstract
The molecular defects responsible for tumor cell hypermutability in humans have not yet been fully identified. Here the gene encoding a G/T mismatch-binding protein (GTBP) was localized to within 1 megabase of the related hMSH2 gene on chromosome 2 and was found to be inactivated in three hypermutable cell lines. Unlike cells defective in other mismatch repair genes, which display widespread alterations in mononucleotide, dinucleotide, and other simple repeated sequences, the GTBP-deficient cells showed alterations primarily in mononucleotide tracts. These results suggest GTBP is important for maintaining the integrity of the human genome and document molecular defects accounting for variation in mutator phenotype.
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Citations
Cited by
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
Self-citationIsolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells
Drummond, J. T., Li, G.-M., Longley, M. J., & Modrich, P. (1995) · Science · doi:10.1126/science.7604264 · Cited by 601
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair
Marsischky, G. T., Filosi, N., Kane, M. F., & Kolodner, R. (1996) · Genes & Development · doi:10.1101/gad.10.4.407 · Cited by 581
Buermeyer, A. B., Deschênes, S. M., Baker, S. M., & Liskay, R. M. (1999) · Annual Review of Genetics · doi:10.1146/annurev.genet.33.1.533 · Cited by 451
hMutSβ, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA
Palombo, F., Iaccarino, I., Nakajima, E., Ikejima, M., Shimada, T., & Jiricny, J. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70685-4 · Cited by 371
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Metadata
- Authors
- Papadopoulos, N., Nicolaides, N. C., Liu, B., Parsons, R., Lengauer, C., Palombo, F., D'Arrigo, A., Markowitz, S., Willson, J. K. V., Kinzler, K. W., Jiricny, J., & Vogelstein, B.
- Venue
- Science
- Published
- 1995-06-30
- Volume
- 268
- Issue
- 5219
- Pages
- 1915-1917
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1983811214
- Cited by
- 468
- References
- 0
- FWCI
- 20.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Mutations of GTBP in Genetically Unstable Cells. https://app.cochat.ai/papers/10.1126/science.7604266
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- Papadopoulos, N., Nicolaides, N. C., Liu, B., Parsons, R., Lengauer, C., Palombo, F., D'Arrigo, A., Markowitz, S., Willson, J. K. V., Kinzler, K. W., Jiricny, J., & Vogelstein, B. (1995). Mutations of GTBP in Genetically Unstable Cells. Science. https://doi.org/10.1126/science.7604266
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
