The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Rational Design of Peptide Antibiotics by Targeted Replacement of Bacterial and Fungal Domains
Abstract
Peptide synthetases involved in the nonribosomal synthesis of peptide secondary metabolites possess a highly conserved domain structure. The arrangement of these domains within the multifunctional enzymes determines the number and order of the amino acid constituents of the peptide product. A general approach has been developed for targeted substitution of amino acid-activating domains within the srfA operon, which encodes the protein templates for the synthesis of the lipopeptide antibiotic surfactin in Bacillus subtilis . Exchange of domain-coding regions of bacterial and fungal origin led to the construction of hybrid genes that encoded peptide synthetases with altered amino acid specificities and the production of peptides with modified amino acid sequences.
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Cites
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Self-citationSequence and analysis of the genetic locus responsible for surfactin synthesis in Bacillus subtilis
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Nakano, M. M., Corbell, N., Besson, J., & Zuber, P. (1992) · Molecular and General Genetics MGG · doi:10.1007/bf00280011 · Cited by 275
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Self-citationPiezoelectric properties of dry and wet bone
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Cited by
Nonribosomal Peptide Synthesis—Principles and Prospects
Süssmuth, R. D., & Mainz, A. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201609079 · Cited by 958
Frey-Klett, P., Burlinson, P., Deveau, A., Barret, M., Tarkka, M., & Sarniguet, A. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00020-11 · Cited by 913
Quadri, L. E. N., Weinreb, P. H., Lei, M., Nakano, M. M., Zuber, P., & Walsh, C. T. (1998) · Biochemistry · doi:10.1021/bi9719861 · Cited by 693
Molecular Mechanisms Underlying Nonribosomal Peptide Synthesis: Approaches to New Antibiotics
Sieber, S. A., & Marahiel, M. A. (2005) · Chemical Reviews · doi:10.1021/cr0301191 · Cited by 592
Self-citationNonribosomal peptides: from genes to products
Schwarzer, D., Finking, R., & Marahiel, M. A. (2003) · Natural Product Reports · doi:10.1039/b111145k · Cited by 585
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Metadata
- Authors
- Stachelhaus, T., Schneider, A., & Marahiel, M. A.
- Venue
- Science
- Published
- 1995-07-07
- Volume
- 269
- Issue
- 5220
- Pages
- 69-72
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2089475202
- Cited by
- 340
- References
- 23
- FWCI
- 16.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Stachelhaus, T., Schneider, A., & Marahiel, M. A. (1995). Rational Design of Peptide Antibiotics by Targeted Replacement of Bacterial and Fungal Domains. Science. https://doi.org/10.1126/science.7604280
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
