The DOI matches its Crossref record.
Requirement of Mip-1α for an Inflammatory Response to Viral Infection
Abstract
Macrophage inflammatory protein-1α (MIP-1α) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1α had been disrupted. Homozygous MIP-1α mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice. Influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ mice. The -/- mice had no overt hematopoietic abnormalities. These results demonstrate that MIP-1α is an important mediator of virus-induced inflammation in vivo.
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Cited by
International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors
Murphy, P. M., Baggiolini, M., Charo, I. F., Hébert, C. A., Horuk, R., Matsushima, K., Miller, L. H., Oppenheim, J. J., & Power, C. A. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01439-x · Cited by 1,817
Boring, L., Gosling, J., Chensue, S. W., Kunkel, S. L., Farese, R. V., Broxmeyer, H. E., & Charo, I. F. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119798 · Cited by 1,096
Shaffer, A. L., Yu, X., He, Y., Boldrick, J., Chan, E. P., & Staudt, L. M. (2000) · Immunity · doi:10.1016/s1074-7613(00)00020-0 · Cited by 724
Gao, J.-L., Wynn, T. A., Chang, Y., Lee, E. J., Broxmeyer, H. E., Cooper, S., Tiffany, H. L., Westphal, H., Kwon-Chung, J., & Murphy, P. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.11.1959 · Cited by 441
Mechanisms of sex disparities in influenza pathogenesis
Klein, S. L., Hodgson, A., & Robinson, D. P. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0811427 · Cited by 219
Metadata
- Authors
- Cook, D. N., Beck, M. A., Coffman, T. M., Kirby, S. L., Sheridan, J. F., Pragnell, L. B., & Smithies, O.
- Venue
- Science
- Published
- 1995-09-15
- Volume
- 269
- Issue
- 5230
- Pages
- 1583-1585
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2020164587
- Cited by
- 617
- References
- 0
- FWCI
- 19.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Requirement of Mip-1α for an Inflammatory Response to Viral Infection. https://app.cochat.ai/papers/10.1126/science.7667639
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- Cook, D. N., Beck, M. A., Coffman, T. M., Kirby, S. L., Sheridan, J. F., Pragnell, L. B., & Smithies, O. (1995). Requirement of Mip-1α for an Inflammatory Response to Viral Infection. Science. https://doi.org/10.1126/science.7667639
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
