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BCL-6 Represses Genes that Function in Lymphocyte Differentiation, Inflammation, and Cell Cycle Control

Shaffer, A.L, Yu, Xin, He, Yunsheng, Boldrick, Jennifer, Chan, Erick P, Staudt, Louis M·2000·Immunity
DOI 10.1016/s1074-7613(00)00020-0
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Abstract

BCL-6, a transcriptional repressor frequently translocated in lymphomas, regulates germinal center B cell differentiation and inflammation. DNA microarray screening identified genes repressed by BCL-6, including many lymphocyte activation genes, suggesting that BCL-6 modulates B cell receptor signals. BCL-6 repression of two chemokine genes, MIP-1alpha and IP-10, may also attenuate inflammatory responses. Blimp-1, another BCL-6 target, is important for plasmacytic differentiation. Since BCL-6 expression is silenced in plasma cells, repression of blimp-1 by BCL-6 may control plasmacytic differentiation. Indeed, inhibition of BCL-6 function initiated changes indicative of plasmacytic differentiation, including decreased expression of c-Myc and increased expression of the cell cycle inhibitor p27kip1. These data suggest that malignant transformation by BCL-6 involves inhibition of differentiation and enhanced proliferation.

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Research works printed but not linked: 49

  1. Alizadeh, 1999, The lymphochip, Cold Spring Harb. Symp. Quant. Biol., 64, 71, 10.1101/sqb.1999.64.71 · DOI
  2. Alizadeh, 2000, Identification of molecularly and clinically distinct types of diffuse large B-cell lymphoma by gene expression profiling, Nature, 403, 503, 10.1038/35000501 · DOI · Paper page
  3. Allman, 1996, BCL-6 expression during B-cell activation, Blood, 87, 5257, 10.1182/blood.V87.12.5257.bloodjournal87125257 · DOI
  4. Baron, 1995, BCL6 encodes a sequence-specific DNA-binding protein, Genes Chromosomes Cancer, 13, 221, 10.1002/gcc.2870130314 · DOI
  5. Briegel, 1996, Regulation and function of transcription factor GATA-1 during red blood cell differentiation, Development, 122, 3839, 10.1242/dev.122.12.3839 · DOI
  6. Camp, 1991, High levels of CD44 expression distinguish virgin from antigen-primed B cells, J. Exp. Med., 173, 763, 10.1084/jem.173.3.763 · DOI
  7. Carman, 1996, Immature stage B cells enter but do not progress beyond the early G1 phase of the cell cycle in response to antigen receptor signaling, J. Immunol., 156, 4562, 10.4049/jimmunol.156.12.4562 · DOI
  8. Cattoretti, 1995, Bcl-6 protein is expressed in germinal-center B cells, Blood, 86, 45, 10.1182/blood.V86.1.45.bloodjournal86145 · DOI
  9. Cavailles, 1994, Interaction of proteins with transcriptionally active estrogen receptors, Proc. Natl. Acad. Sci. USA, 91, 10009, 10.1073/pnas.91.21.10009 · DOI
  10. Cook, 1995, Requirement of MIP-1 α for an inflammatory response to viral infection, Science, 269, 1583, 10.1126/science.7667639 · DOI
  11. Dalla-Favera, 1999, Molecular pathogenesis of B cell malignancy, Curr. Top. Microbiol. Immunol., 246, 257
  12. Davies, 1999, Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene, Oncogene, 18, 365, 10.1038/sj.onc.1202332 · DOI
  13. Dent, 1997, Control of inflammation, cytokine expression, and germinal center formation by BCL-6, Science, 276, 589, 10.1126/science.276.5312.589 · DOI
  14. Falini, 2000, A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells, Blood, 95, 2084, 10.1182/blood.V95.6.2084 · DOI
  15. Farber, 1997, Mig and IP-10, J. Leukoc. Biol., 61, 246, 10.1002/jlb.61.3.246 · DOI
  16. Fero, 1996, A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice, Cell, 85, 733, 10.1016/S0092-8674(00)81239-8 · DOI
  17. Fero, 1998, The murine gene p27Kip1 is haplo-insufficient for tumour suppression, Nature, 396, 177, 10.1038/24179 · DOI
  18. Francis, 1995, Analysis of the hormone-dependent regulation of a JunD-estrogen receptor chimera, J. Biol. Chem., 270, 11502, 10.1074/jbc.270.19.11502 · DOI
  19. Fukuda, 1997, Disruption of the Bcl6 gene results in an impaired germinal center formation, J. Exp. Med., 186, 439, 10.1084/jem.186.3.439 · DOI
  20. Gupta, 1999, Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4, J. Exp. Med., 190, 1837, 10.1084/jem.190.12.1837 · DOI
  21. Harris, 1999, Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6, Mol. Cell. Biol., 19, 7264, 10.1128/MCB.19.10.7264 · DOI
  22. Jun, 1997, Characterization of the murine cyclin D2 gene, Mol. Cells, 7, 537, 10.1016/S1016-8478(23)13334-6 · DOI
  23. Kiyokawa, 1996, Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1), Cell, 85, 721, 10.1016/S0092-8674(00)81238-6 · DOI
  24. Knodel, 1999, Reversal of Blimp-1-mediated apoptosis by A1, a member of the Bcl-2 family, Eur. J. Immunol., 29, 2988, 10.1002/(SICI)1521-4141(199909)29:09<2988::AID-IMMU2988>3.0.CO;2-T · DOI
  25. Krzysiek, 1999, Antigen receptor engagement selectively induces macrophage inflammatory protein-1 alpha (MIP-1 α) and MIP-1 β chemokine production in human B cells, J. Immunol., 162, 4455, 10.4049/jimmunol.162.8.4455 · DOI
  26. Lin, 1997, Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation, Science, 276, 596, 10.1126/science.276.5312.596 · DOI
  27. Lopez-Cabrera, 1995, Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-α-responsive elements, J. Biol. Chem., 270, 21545, 10.1074/jbc.270.37.21545 · DOI
  28. Lukacs, 1995, Macrophage inflammatory protein-1 α influences eosinophil recruitment in antigen-specific airway inflammation, Eur. J. Immunol., 25, 245, 10.1002/eji.1830250140 · DOI
  29. Messika, 1998, Differential effect of B lymphocyte-induced maturation protein (Blimp-1) expression on cell fate during B cell development, J. Exp. Med., 188, 515, 10.1084/jem.188.3.515 · DOI
  30. Miller, 1993, Epstein-Barr virus latent membrane protein 2A blocks calcium mobilization in B lymphocytes, J. Virol., 67, 3087, 10.1128/JVI.67.6.3087-3094.1993 · DOI
  31. Nakayama, 1996, Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors, Cell, 85, 707, 10.1016/S0092-8674(00)81237-4 · DOI
  32. Onizuka, 1995, BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts, Blood, 86, 28, 10.1182/blood.V86.1.28.bloodjournal86128 · DOI
  33. Polyak, 1994, p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest, Genes Dev., 8, 9, 10.1101/gad.8.1.9 · DOI
  34. Quintanilla-Martinez, 1998, Mantle cell lymphomas lack expression of p27Kip1, a cyclin-dependent kinase inhibitor, Am. J. Pathol., 153, 175, 10.1016/S0002-9440(10)65558-7 · DOI
  35. Quong, 1999, E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination, EMBO J., 18, 6307, 10.1093/emboj/18.22.6307 · DOI
  36. Sanchez-Beato, 1999, Anomalous high p27/KIP1 expression in a subset of aggressive B-cell lymphomas is associated with cyclin D3 overexpression. p27/KIP1-cyclin D3 colocalization in tumor cells, Blood, 94, 765, 10.1182/blood.V94.2.765 · DOI
  37. Schall, 1993, Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta chemokines attract distinct populations of lymphocytes, J. Exp. Med., 177, 1821, 10.1084/jem.177.6.1821 · DOI
  38. Seyfert, 1996, Transcriptional repression by the proto-oncogene BCL-6, Oncogene, 12, 2331
  39. Shim, 1997, c-Myc transactivation of LDH-A, Proc. Natl. Acad. Sci. USA, 94, 6658, 10.1073/pnas.94.13.6658 · DOI · Paper page
  40. Solvason, 1996, Induction of cell cycle regulatory proteins in anti-immunoglobulin-stimulated mature B lymphocytes, J. Exp. Med., 184, 407, 10.1084/jem.184.2.407 · DOI
  41. Soro, 1999, Differential involvement of the transcription factor Blimp-1 in T cell-independent and -dependent B cell differentiation to plasma cells, J. Immunol., 163, 611, 10.4049/jimmunol.163.2.611 · DOI
  42. Staudt, 1999, Regulation of lymphocyte cell fate decisions and lymphomagenesis by BCL-6, Int J. Immunol., 18, 381
  43. Toyoshima, 1994, p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21, Cell, 78, 67, 10.1016/0092-8674(94)90573-8 · DOI
  44. Turner, 1994, Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells, Cell, 77, 297, 10.1016/0092-8674(94)90321-2 · DOI
  45. Wagner, 1993, c-Myc induces the expression and activity of ornithine decarboxylase, Cell Growth Differ., 4, 879
  46. Wheeler, 1996, Co-ligation of surface IgM and CD40 on naive B lymphocytes generates a blast population with an ambiguous extrafollicular/germinal centre cell phenotype, Int. Immunol., 8, 815, 10.1093/intimm/8.6.815 · DOI
  47. Widmer, 1993, Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1α, and MIP-1β, members of the chemokine superfamily of proinflammatory cytokines, J. Immunol., 150, 4996, 10.4049/jimmunol.150.11.4996 · DOI
  48. Yang, 1997, Cloning and functional analysis of rat cyclin D2 promoter, Biochem. Mol. Biol. Int., 43, 749
  49. Ye, 1997, The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation, Nat. Genet., 16, 161, 10.1038/ng0697-161 · DOI

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Metadata

Authors
Shaffer, A. L., Yu, X., He, Y., Boldrick, J., Chan, E. P., & Staudt, L. M.
Venue
Immunity
Publisher
Elsevier BV
Published
2000-08
Volume
13
Issue
2
Pages
199-212
ISSN
1074-7613
DOI
10.1016/s1074-7613(00)00020-0
Cited by
724
References
1
Language
en
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Shaffer, A. L., Yu, X., He, Y., Boldrick, J., Chan, E. P., & Staudt, L. M. (2000). BCL-6 Represses Genes that Function in Lymphocyte Differentiation, Inflammation, and Cell Cycle Control. Immunity. https://doi.org/10.1016/s1074-7613(00)00020-0