The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation
Abstract
Regulation of cell proliferation, differentiation, and metabolic homeostasis is associated with the phosphorylation and dephosphorylation of specific tyrosine residues of key regulatory proteins. The phosphotyrosine phosphatase 1D (PTP 1D) contains two amino terminally located Src homology 2 (SH2) domains and is similar to the Drosophila corkscrew gene product, which positively regulates the torso tyrosine kinase signal transduction pathway. PTP activity was found to be regulated by physical interaction with a protein tyrosine kinase. PTP 1D did not dephosphorylate receptor tyrosine kinases, despite the fact that it associated with the epidermal growth factor receptor and chimeric receptors containing the extracellular domain of the epidermal growth factor receptor and the cytoplasmic domain of either the HER2- neu , kit -SCF, or platelet-derived growth factor β (βPDGF) receptors. PTP 1D was phosphorylated on tyrosine in cells overexpressing the βPDGF receptor kinase and this tyrosine phosphorylation correlated with an enhancement of its catalytic activity. Thus, protein tyrosine kinases and phosphatases do not simply oppose each other's action; rather, they may work in concert to maintain a fine balance of effector activation needed for the regulation of cell growth and differentiation.
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DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
Signal transduction by receptors with tyrosine kinase activity
Ullrich, A., & Schlessinger, J. (1990) · Cell · doi:10.1016/0092-8674(90)90801-k · Cited by 5,435
Self-citationSH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins
Koch, C. A., Anderson, D., Moran, M. F., Ellis, C., & Pawson, T. (1991) · Science · doi:10.1126/science.1708916 · Cited by 1,868
Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes
Fischer, E. H., Charbonneau, H., & Tonks, N. K. (1991) · Science · doi:10.1126/science.1650499 · Cited by 956
Meisenhelder, J., Suh, P.-G., Rhee, S. G., & Hunter, T. (1989) · Cell · doi:10.1016/0092-8674(89)90048-2 · Cited by 955
Margolis, B., Rhee, S. G., Felder, S., Mervic, M., Lyall, R., Levitzki, A., Ullrich, A., Zilberstein, A., & Schlessinger, J. (1989) · Cell · doi:10.1016/0092-8674(89)90047-0 · Cited by 753
Self-citationSH2-Containing Phosphotyrosine Phosphatase as a Target of Protein-Tyrosine Kinases
Feng, G.-S., Hui, C.-C., & Pawson, T. (1993) · Science · doi:10.1126/science.8096088 · Cited by 661
Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation
Nishibe, S., Wahl, M. I., Hernandez-Sotomayor, S. M., Tonks, N. K., Rhee, S. G., & Carpenter, G. (1990) · Science · doi:10.1126/science.1700866 · Cited by 635
Horizontal integration and cortical dynamics
Gilbert, C. D. (1992) · Neuron · doi:10.1016/0896-6273(92)90215-y · Cited by 583
Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase
Zheng, X. M., Wang, Y., & Fallen, C. J. (1992) · Nature · doi:10.1038/359336a0 · Cited by 449
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HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal · doi:10.1042/bj3340297 · Cited by 2,130
Prenzel, N., Zwick, E., Daub, H., Leserer, M., Abraham, R., Wallasch, C., & Ullrich, A. (1999) · Nature · doi:10.1038/47260 · Cited by 1,504
Self-citationCrystal Structure of the Tyrosine Phosphatase SHP-2
Hof, P., Pluskey, S., Dhe-Paganon, S., Eck, M. J., & Shoelson, S. E. (1998) · Cell · doi:10.1016/s0092-8674(00)80938-1 · Cited by 985
IL-6 signal transduction and its physiological roles: the signal orchestration model
Kamimura, D., Ishihara, K., & Hirano, T. (2003) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/s10254-003-0012-2 · Cited by 673
Newman, P. J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119129 · Cited by 664
Metadata
- Authors
- Vogel, W., Lammers, R., Huang, J., & Ullrich, A.
- Venue
- Science
- Published
- 1993-03-12
- Volume
- 259
- Issue
- 5101
- Pages
- 1611-1614
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2083800765
- Cited by
- 549
- References
- 22
- FWCI
- 27.23
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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