The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Oral Immunization with a Recombinant Bacterial Antigen Produced in Transgenic Plants
Abstract
The binding subunit of Escherichia coli heat-labile enterotoxin (LT-B) is a highly active oral immunogen. Transgenic tobacco and potato plants were made with the use of genes encoding LT-B or an LT-B fusion protein with a microsomal retention sequence. The plants expressed the foreign peptides, both of which formed oligomers that bound the natural ligand. Mice immunized by gavage produced serum and gut mucosal anti-LT-B immunoglobulins that neutralized the enterotoxin in cell protection assays. Feeding mice fresh transgenic potato tubers also caused oral immunization.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Cited by
(2001) · Cited by 829
Daniell, H., Lee, S.-B., Panchal, T., & Wiebe, P. O. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4921 · Cited by 398
Expression of the Rabies Virus Glycoprotein in Transgenic Tomatoes
McGarvey, P. B., Hammond, J., Dienelt, M. M., Hooper, D. C., Fu, Z. F., Dietzschold, B., Koprowski, H., & Michaels, F. H. (1995) · Nature Biotechnology · doi:10.1038/nbt1295-1484 · Cited by 275
Enhancing Oral Vaccine Potency by Targeting Intestinal M Cells
Azizi, A., Kumar, A., Diaz-Mitoma, F., & Mestecky, J. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001147 · Cited by 180
Metadata
- Authors
- Haq, T. A., Mason, H. S., Clements, J. D., & Arntzen, C. J.
- Venue
- Science
- Published
- 1995-05-05
- Volume
- 268
- Issue
- 5211
- Pages
- 714-716
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1980475055
- Cited by
- 622
- References
- 1
- FWCI
- 29.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Haq, T. A., Mason, H. S., Clements, J. D., & Arntzen, C. J. (1995). Oral Immunization with a Recombinant Bacterial Antigen Produced in Transgenic Plants. Science. https://doi.org/10.1126/science.7732379
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
