Enhancing Oral Vaccine Potency by Targeting Intestinal M Cells

Mucosal immunity and vaccines

Holmgren, J. R., & Czerkinsky, C. C. (2005) · Nature Medicine · doi:10.1038/nm1213 · Cited by 1,559 · see citing works

Use of the Inactivated Intranasal Influenza Vaccine and the Risk of Bell's Palsy in Switzerland

Mütsch, M., Zhou, W., Rhodes, P., Bopp, M., Chen, R. T., Linder, T. E., Spyr, C., & Steffen, R. P. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa030595 · Cited by 918 · see citing works

The mucosal immune system: from fundamental concepts to vaccine development

McGhee, J. R., Mestecky, J. F., Dertzbaugh, M. T., Eldridge, J. H., Hirasawa, M., & Kiyono, H. (1992) · Vaccine · doi:10.1016/0264-410x(92)90021-b · Cited by 904 · see citing works

The common mucosal immune system and current strategies for induction of immune responses in external secretions

Mestecky, J. F. (1987) · Journal of Clinical Immunology · doi:10.1007/bf00915547 · Cited by 819 · see citing works

Epithelial Cell Specialization within Human Peyer's Patches: An Ultrastructural Study of Intestinal Lymphoid Follicles

Owen, R. L., & Jones, A. L. (1974) · Gastroenterology · doi:10.1016/s0016-5085(74)80102-2 · Cited by 765 · see citing works

Conversion by Peyer's Patch Lymphocytes of Human Enterocytes into M Cells that Transport Bacteria

Kernéis, S. M., Bogdanova, A. A., Kraehenbühl, J.-P., & Pringault, E. (1997) · Science · doi:10.1126/science.277.5328.949 · Cited by 630 · see citing works

Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response

Hase, K., Kawano, K., Nochi, T., Pontes, G., Fukuda, S., Ebisawa, M., Kadokura, K., Tobe, T., Fujimura, Y., Kawano, S., et al. (2009) · Nature · doi:10.1038/nature08529 · Cited by 625 · see citing works

Oral Immunization with a Recombinant Bacterial Antigen Produced in Transgenic Plants

Haq, T. A., Mason, H. S., Clements, J. D., & Arntzen, C. J. (1995) · Science · doi:10.1126/science.7732379 · Cited by 622 · see citing works

Oral tolerance

Faria, A. M. C., & Weiner, H. L. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00280.x · Cited by 601 · see citing works

Fibronectin-binding protein acts as Staphylococcus aureus invasin via fibronectin bridging to integrin alpha5beta1

Sinha, B. N. M., François, P., Nüße, O., Foti, M., Hartford, O. M., Vaudaux, P. E., Foster, T. J., Lew, D. P., Herrmann, M., & Krause, K. (1999) · Cellular Microbiology · doi:10.1046/j.1462-5822.1999.00011.x · Cited by 565 · see citing works

Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria

Wells, J. M., & Mercenier, A. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1840 · Cited by 542 · see citing works

Intestinal villous M cells: An antigen entry site in the mucosal epithelium

Jang, M. H., Kweon, M., Iwatani, K., Yamamoto, M., Terahara, K., Sasakawa, C., Suzuki, T., Nochi, T., Yokota, Y., Rennert, P. D., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400969101 · Cited by 471 · see citing works

Oral tolerance.

Weiner, H. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.10762 · Cited by 455 · see citing works

Receptor binding studies disclose a novel class of high‐affinity inhibitors of the Escherichia coli FimH adhesin

Bouckaert, J. M. J., Berglund, J., Schembri, M. A., Genst, E. D., Cools, L., Wuhrer, M., Hung, C., Pinkner, J. S., Slättegård, R., Zavialov, A. V., et al. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04415.x · Cited by 448 · see citing works

Altered peptidase and viral-specific T cell response in LMP2 mutant mice

Kaer, L. V., Ashton‐Rickardt, P. G., Eichelberger, M. C., Gaczynska, M. E., Nagashima, K., Rock, K. L., Goldberg, A. L., Doherty, P. C., & Tonegawa, S. (1994) · Immunity · doi:10.1016/1074-7613(94)90043-4 · Cited by 447 · see citing works

Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting

Frey, A., Giannasca, K. T., Weltzin, R., Giannasca, P. J., Reggio, H., Lencer, W. I., & Neutra, M. R. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.3.1045 · Cited by 401 · see citing works

Discrete Cleavage Motifs of Constitutive and Immunoproteasomes Revealed by Quantitative Analysis of Cleavage Products

Toes, R. E. M., Nussbaum, A. K., Degermann, S., Schirle, M., Emmerich, N., Kraft, M., Laplace, C., Zwinderman, A. H., Dick, T. P., Müller, J., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.1.1 · Cited by 371 · see citing works

M-Cell Surface β1 Integrin Expression and Invasin-Mediated Targeting of Yersinia pseudotuberculosis to Mouse Peyer’s Patch M Cells

Clark, M. A., Hirst, B. H., & Jepson, M. A. (1998) · Infection and Immunity · doi:10.1128/iai.66.3.1237-1243.1998 · Cited by 363 · see citing works

Vaccination with FimH Adhesin Protects Cynomolgus Monkeys from Colonization and Infection by UropathogenicEscherichia coli

Langermann, S., Möllby, R., Burlein, J. E., Palaszynski, S., Auguste, C. G., DeFusco, A., Strouse, R., Schenerman, M. A., Hultgren, S. J., Pinkner, J. S., et al. (2000) · The Journal of Infectious Diseases · doi:10.1086/315258 · Cited by 337 · see citing works

Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination

Nochi, T., Takagi, H., Yuki, Y., Yang, L., Masumura, T., Mejima, M., Nakanishi, U., Matsumura, A., Uozumi, A., Hiroi, T., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703766104 · Cited by 336 · see citing works

Transient Facial Nerve Paralysis (Bell's Palsy) following Intranasal Delivery of a Genetically Detoxified Mutant of Escherichia coli Heat Labile Toxin

Lewis, D. J., Huo, Z., Barnett, S. W., Kromann, I., Giemza, R., Galiza, E. P., Woodrow, M., Thierry-Carstensen, B., Andersen, P. L., Novicki, D. L., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006999 · Cited by 305 · see citing works

Comparison of the oral, rectal, and vaginal immunization routes for induction of antibodies in rectal and genital tract secretions of women

Kozlowski, P. A., Cu‐Uvin, S., Neutra, M. R., & Flanigan, T. (1997) · Infection and Immunity · doi:10.1128/iai.65.4.1387-1394.1997 · Cited by 294 · see citing works

Expression of specific markers and particle transport in a new human intestinal M-cell model

Gullberg, E., Leonard, M., Karlsson, J., Hopkins, A. M., Brayden, D., Baird, A. W., & Artursson, P. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4038 · Cited by 270 · see citing works

Intranasal vaccination of humans with recombinant cholera toxin B subunit induces systemic and local antibody responses in the upper respiratory tract and the vagina

Bergquist, C., Johansson, E.-L., Lagergård, T., Holmgren, J. R., & Rudin, A. (1997) · Infection and Immunity · doi:10.1128/iai.65.7.2676-2684.1997 · Cited by 261 · see citing works

Seasonal Influenza Vaccines

Fiore, A. E., Bridges, C. B., & Cox, N. J. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-92165-3_3 · Cited by 249 · see citing works

Induction of specific immunoglobulin A in the small intestine, colon-rectum, and vagina measured by a new method for collection of secretions from local mucosal surfaces

Haneberg, B., Kendall, D., Amerongen, H. M., Apter, F. M., Kraehenbühl, J. P., & Neutra, M. R. (1994) · Infection and Immunity · doi:10.1128/iai.62.1.15-23.1994 · Cited by 248 · see citing works

A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses

Jackson, D. C., Lau, Y. F., Le, T., Suhrbier, A., Deliyannis, G., Cheers, C., Smith, C., Zeng, W., & Brown, L. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406740101 · Cited by 236 · see citing works

Proteolysis and class I major histocompatibility complex antigen presentation

York, I. A., Goldberg, A. L., Mo, X. Y., & Rock, K. L. (1999) · Immunological Reviews · doi:10.1111/j.1600-065x.1999.tb01355.x · Cited by 232 · see citing works

Keynote review: intestinal Peyer's patch M cells and oral vaccine targeting

Brayden, D. J., Jepson, M. A., & Baird, A. W. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03536-1 · Cited by 224 · see citing works

Differential Induction of Mucosal and Systemic Antibody Responses in Women After Nasal, Rectal, or Vaginal Immunization: Influence of the Menstrual Cycle

Kozlowski, P. A., Williams, S. B., Lynch, R. M., Flanigan, T., Patterson, R. R., Cu‐Uvin, S., & Neutra, M. R. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.566 · Cited by 223 · see citing works

Plants for delivery of edible vaccines

Walmsley, A. M., & Arntzen, C. J. (2000) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(00)00070-7 · Cited by 212 · see citing works

Lactic acid bacteria as antigen delivery vehicles for oral immunization purposes

Pouwels, P. H., Leer, R. J., Shaw, M., Bak‐Glashouwer, M. ‐. H. D., Tielen, F. D., Smit, E., Martı́nez, B., Jore, J., & Conway, P. L. (1998) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(98)00048-8 · Cited by 191 · see citing works

The morphological characteristics of andisols

Leamy, M. L., Smith, G. D., Colmet-Daage, F., & Otowa, M. (1984) · Cited by 183 · see citing works

Oxidation‐specific epitopes are important targets of innate immunity

Chou, M. ‐., Hartvigsen, K., Hansen, L. F., Fogelstrand, L., Shaw, P. X., Boullier, A., Binder, C. J., & Witztum, J. L. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.01968.x · Cited by 179 · see citing works

Comprehensive Gene Expression Profiling of Peyer’s Patch M Cells, Villous M-Like Cells, and Intestinal Epithelial Cells

Terahara, K., Yoshida, M., Igarashi, O., Nochi, T., Pontes, G. S., Hase, K., Ohno, H., Kurokawa, S., Mejima, M., Satoh‐Takayama, N., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.12.7840 · Cited by 170 · see citing works

Immunologic Uniqueness of the Genital Tract: Challenge for Vaccine Development

Mestecky, J. F., Moldoveanu, Z., & Russell, M. W. (2005) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2005.00267.x · Cited by 170 · see citing works

Recruitment of Uterine NK Cells: Induction of CXC Chemokine Ligands 10 and 11 in Human Endometrium by Estradiol and Progesterone

Sentman, C. L., Meadows, S. K., Wira, C. R., & Eriksson, M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.11.6760 · Cited by 167 · see citing works

Lipid vesicle size of an oral influenza vaccine delivery vehicle influences the Th1/Th2 bias in the immune response and protection against infection

Mann, J. F. S., Shakir, E., Carter, K. C., Mullen, A. B., Alexander, J. K., & Ferro, V. A. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.03.040 · Cited by 166 · see citing works

Human Intestinal M Cells Display the Sialyl Lewis A Antigen

Giannasca, P. J., Giannasca, K. T., Leichtner, A. M., & Neutra, M. R. (1999) · Infection and Immunity · doi:10.1128/iai.67.2.946-953.1999 · Cited by 155 · see citing works

Lipopolysaccharide Binding Protein Binds to Triacylated and Diacylated Lipopeptides and Mediates Innate Immune Responses

Schröder, N. W. J., Heine, H., Alexander, C., Manukyan, M., Eckert, J., Hamann, L., Göbel, U. B., & Schumann, R. R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.4.2683 · Cited by 154 · see citing works

Perspectives on Mucosal Vaccines: Is Mucosal Tolerance a Barrier?

Mestecky, J. F., Russell, M. W., & Elson, C. O. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.9.5633 · Cited by 148 · see citing works

Distinct Proteolytic Processes Generate the C and N Termini of MHC Class I-Binding Peptides

Mo, X. Y., Cascio, P., Lemerise, K., Goldberg, A. L., & Rock, K. L. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.11.5851 · Cited by 142 · see citing works

M-cell targeted biodegradable PLGA nanoparticles for oral immunization against hepatitis B

Gupta, P. N., Khatri, K., Goyal, A. K., Mishra, N., & Vyas, S. P. (2007) · Journal of Drug Targeting · doi:10.1080/10611860701637982 · Cited by 136 · see citing works

The role of M cells in mucosal immunity

Hathaway, L. J., & Kraehenbuhl*, J.-P. (2000) · Cellular and Molecular Life Sciences CMLS · doi:10.1007/pl00000693 · Cited by 131 · see citing works

Comparison of intranasal inoculation of influenza HA vaccine combined with cholera toxin B subunit with oral or parenteral vaccination

Hirabayashi, Y., Kurata, H., Funato, H., Nagamine, T., Aizawa, C., Tamura, S., Shimada, K., & Kurata, T. (1990) · Vaccine · doi:10.1016/0264-410x(90)90053-o · Cited by 125 · see citing works

Evaluation of the immune response following a short oral vaccination schedule with hepatitis B antigen encapsulated into alginate-coated chitosan nanoparticles

Borges, O., Tavares, J., de Sousa, A., Borchard, G., Junginger, H. E., & Cordeiro‐da‐Silva, A. (2007) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2007.08.005 · Cited by 121 · see citing works

CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients

Speiser, D. E., Valmori, D., Rimoldi, D., Pittet, M. J., Líénard, D., Cerundolo, V., MacDonald, H. R., Cerottini, J., & Romero, P. J. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199906)29:06 · Cited by 119 · see citing works

Mucosal vaccines: novel advances in technology and delivery

Yuki, Y., & Kiyono, H. (2009) · Expert Review of Vaccines · doi:10.1586/erv.09.61 · Cited by 109 · see citing works

Oral immunization of adult volunteers with microencapsulated enterotoxigenic Escherichia coli (ETEC) CS6 antigen

Katz, D. E., Delorimier, A., Wolf, M. K., Hall, E. R., Cassels, F. J., van Hamont, J. E., Newcomer, R., Davachi, M. A., Taylor, D. N., & McQueen, C. E. (2003) · Vaccine · doi:10.1016/s0264-410x(02)00613-8 · Cited by 109 · see citing works

Enhanced mucosal and systemic immune response with intranasal immunization of mice with HIV peptides entrapped in PLG microparticles in combination with Ulex Europaeus-I lectin as M cell target

Manocha, M., Pal, P. C., Chitralekha, K. T., Thomas, B. E., Tripathi, V., Gupta, S. D., Paranjape, R., Kulkarni, S., & Rao, D. N. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.06.031 · Cited by 103 · see citing works

Mucosal immunogenicity of plant lectins in mice

Lavelle, E. C., Grant, G., Pusztai, A. J., Pfüller, U., & O’Hagan, D. T. (2000) · Immunology · doi:10.1046/j.1365-2567.2000.00932.x · Cited by 99 · see citing works

M cells at locations outside the gut

Gebert, A., & Pabst, R. (1999) · Seminars in Immunology · doi:10.1006/smim.1999.0172 · Cited by 93 · see citing works

The Development of M Cells in Peyer's Patches Is Restricted to Specialized Dome-Associated Crypts

Gebert, A., Fassbender, S., Werner, K., & Weissferdt, A. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65410-7 · Cited by 92 · see citing works

Intranasal immunization with a plant virus expressing a peptide from HIV-1 gp41 stimulates better mucosal and systemic HIV-1-specific IgA and IgG than oral immunization

Durrani, Z., McInerney, T. L., McLain, L., Jones, T. D., Bellaby, T., Brennan, F. R., & Dimmock, N. J. (1998) · Journal of Immunological Methods · doi:10.1016/s0022-1759(98)00145-8 · Cited by 88 · see citing works

Oral Vaccination withSalmonella entericaas a Cruzipain-DNA Delivery System Confers Protective Immunity againstTrypanosoma cruzi

Cazorla, S. I., Becker, P. D., Frank, F. M., Ebensen, T., Sartori, M. J., Corral, R. S., Malchiodi, E. L., & Guzmán, C. A. (2007) · Infection and Immunity · doi:10.1128/iai.01163-07 · Cited by 87 · see citing works

Cell activation by synthetic lipopeptides of the hepatitis C virus (HCV)—core protein is mediated by toll like receptors (TLRs) 2 and 4

Düesberg, U., Bussche, A. V. D., Kirschning, C. J., Miyake, K., Sauerbruch, T., & Spengler, U. (2002) · Immunology Letters · doi:10.1016/s0165-2478(02)00178-5 · Cited by 84 · see citing works

A Rice-Based Oral Cholera Vaccine Induces Macaque-Specific Systemic Neutralizing Antibodies but Does Not Influence Pre-Existing Intestinal Immunity

Nochi, T., Yuki, Y., Katakai, Y., Shibata, H., Tokuhara, D., Mejima, M., Kurokawa, S., Takahashi, Y., Nakanishi, U., Ono, F., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901480 · Cited by 81 · see citing works

Innovative bioinformatic approaches for developing peptide‐based vaccines against hypervariable viruses

Sirskyj, D., Díaz‐Mitoma, F., Golshani, A., Kumar, A., & Azizi, A. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.65 · Cited by 80 · see citing works

Oral delivery of DNA vaccine encoding VP28 against white spot syndrome virus in crayfish by attenuated Salmonella typhimurium

Ning, J.-F., Zhu, W., Xu, J.-P., Zheng, C.-Y., & Meng, X.-L. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.11.075 · Cited by 77 · see citing works

Up‐regulation of microsphere transport across the follicle‐associated epithelium of Peyer's patch by exposure to Streptococcus pneumoniae R36a

Meynell, H. M., Thomas, N. W., James, P. S., Holland, J., Taussig, M., & Nicoletti, C. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.6.611 · Cited by 76 · see citing works

Induction of β-defensin 3 in keratinocytes stimulated by bacterial lipopeptides through toll-like receptor 2

Sumikawa, Y., Asada, H., Hoshino, K., Azukizawa, H., Katayama, I., Akira, S., & Itami, S. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2006.01.008 · Cited by 74 · see citing works

Optimisation of a lipid based oral delivery system containing A/Panama influenza haemagglutinin

Mann, J. F. S., Ferro, V. A., Mullen, A. B., Tetley, L., Mullen, M., Carter, K. C., Alexander, J. K., & STIMSON, W. H. (2004) · Vaccine · doi:10.1016/j.vaccine.2003.11.067 · Cited by 71 · see citing works

Immunoglobulin Concentrations and Antigen-Specific Antibody Levels in Cervicovaginal Lavages of Rhesus Macaques Are Influenced by the Stage of the Menstrual Cycle

Lü, F. X., Ma, Z.-M., Rourke, T., Srinivasan, S., McChesney, M. B., & Miller, C. J. (1999) · Infection and Immunity · doi:10.1128/iai.67.12.6321-6328.1999 · Cited by 64 · see citing works

Oral immunization: an update

Mestecky, J. F., Nguyen, H. H., Czerkinsky, C. C., & Kiyono, H. (2008) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32830d58be · Cited by 62 · see citing works

Induction of HIV‐specific antibody response and protection against vaginal SHIV transmission by intranasal immunization with inactivated SHIV‐capturing nanospheres in macaques

Miyake, A., Akagi, T., Enose, Y., Ueno, M., Kawamura, M., Horiuchi, R., Hiraishi, K., Adachi, M., Serizawa, T., Narayan, O., et al. (2004) · Journal of Medical Virology · doi:10.1002/jmv.20100 · Cited by 55 · see citing works

Plant-Based Oral Vaccines: Results of Human Trials

Tacket, C. O. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-70868-1_6 · Cited by 55 · see citing works

M cell-targeted delivery of vaccines and therapeutics

KuoLee, R., & Chen, W. (2008) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.6.693 · Cited by 54 · see citing works

Targeted Delivery of Immunogen to Primate M Cells with Tetragalloyl Lysine Dendrimer

Misumi, S., Masuyama, M., Takamune, N., Nakayama, D., Mitsumata, R., Matsumoto, H., Urata, N., Takahashi, Y., Muneoka, A., Sukamoto, T., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802928 · Cited by 53 · see citing works

A Phase I safety and immunogenicity trial of UBI® microparticulate monovalent HIV-1 MN oral peptide immunogen with parenteral boost in HIV-1 seronegative human subjects

Lambert, J. S., Keefer, M. C., Mulligan, M. J., Schwartz, D. H., Mestecky, J., Weinhold, K. J., Smith, C. S., Hsieh, R., Moldoveanu, Z., Fast, P., et al. (2001) · Vaccine · doi:10.1016/s0264-410x(01)00051-2 · Cited by 51 · see citing works

Validation and quantitation of an in vitro M-cell model

Tyrer, P., Ruth Foxwell, A., Kyd, J., Harvey, M., Sizer, P., & Cripps, A. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02631-1 · Cited by 51 · see citing works

Oral administration of low doses of plant-based HBsAg induced antigen-specific IgAs and IgGs in mice, without increasing levels of regulatory T cells

Kostrzak, A., Cervantes-Gonzalez, M., Guétard, D., Devendra, B. N., Wain–Hobson, S., Tepfer, D. A., Pniewski, T., & Sala, M. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.05.092 · Cited by 50 · see citing works

Enteric vaccines for the developing world: a challenge for mucosal immunology

Czerkinsky, C. C., & Holmgren, J. R. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.22 · Cited by 49 · see citing works

Plant-based vaccines for animal health.

Streatfield, S. J. (2005) · PubMed · Cited by 48 · see citing works

A comparison of antibody titres in mouse uterine fluid after immunization by several routes, and the effect of the uterus on antibody titres in vaginal fluid

Parr, E. L., & Parr, M. B. (1990) · Reproduction · doi:10.1530/jrf.0.0890619 · Cited by 47 · see citing works

Intranasal immunization with a recombinant truncated FimH adhesin adjuvanted with CpG oligodeoxynucleotides protects mice against uropathogenicEscherichia colichallenge

Poggio, T. V., Torre, J. L. L., & Scodeller, E. A. (2006) · Canadian Journal of Microbiology · doi:10.1139/w06-065 · Cited by 47 · see citing works

Bell’s Palsy and Parenteral Inactivated Influenza Vaccine

Stowe, J., Andrews, N. J., Wise, L. H., & Miller, E. (2006) · Human Vaccines · doi:10.4161/hv.2790 · Cited by 46 · see citing works

M-Cell Targeting of Whole Killed Bacteria Induces Protective Immunity against Gastrointestinal Pathogens

Chionh, Y. T., Wee, J. L. K., Every, A. L., Ng, G. Z., & SUTTON, P. R. N. (2009) · Infection and Immunity · doi:10.1128/iai.01522-08 · Cited by 46 · see citing works

Oestradiol regulation of antigen presentation by uterine stromal cells: role of transforming growth factor‐β production by epithelial cells in mediating antigen‐presenting cell function

Wira, C. R., & Rossoll, R. M. (2003) · Immunology · doi:10.1046/j.1365-2567.2003.01670.x · Cited by 45 · see citing works

Oral adenoviral-based vaccines: historical perspective and future opportunity

Tucker, S. N., Tingley, D. W., & Scallan, C. D. (2008) · Expert Review of Vaccines · doi:10.1586/14760584.7.1.25 · Cited by 43 · see citing works

Impact of chitosan coating of anionic liposomes on clearance rate, mucosal and systemic immune responses following nasal administration in rabbits

Amin, M., Jaafari, M. R., & Tafaghodi, M. (2009) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2009.07.024 · Cited by 42 · see citing works

DNA prime Listeria boost induces a cellular immune response to SIV antigens in the rhesus macaque model that is capable of limited suppression of SIV239 viral replication

Boyer, J., Robinson, T. M., Maciag, P., Peng, X., Johnson, R. S., Pavlakis, G. N., Lewis, M. G., Shen, A., Siliciano, R. F., Brown, C. R., et al. (2005) · Virology · doi:10.1016/j.virol.2004.12.026 · Cited by 41 · see citing works

Caveolae-mediated entry of Salmonella typhimurium in a human M-cell model

Lim, J. S., Na, H. S., Lee, H. C., Choy, H. E., Park, S. C., Han, J. M., & Cho, K. A. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.10.145 · Cited by 39 · see citing works

A Cocktail of Mycobacterium bovis BCG Recombinants Expressing the SIV Nef, Env, and Gag Antigens Induces Antibody and Cytotoxic Responses in Mice Vaccinated by Different Mucosal Routes

Lagranderie, M., Winter, N., Balazuc, A., Gicquel, B., & Gheorghiu, M. (1998) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1998.14.1625 · Cited by 38 · see citing works

In vivo and in vitro adjuvant activities of the B subunit of Type IIb heat-labile enterotoxin (LT-IIb-B5) from Escherichia coli

Liang, S., Hosur, K. B., Nawar, H. F., Russell, M. W., Connell, J. W., & Hajishengallis, G. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.05.027 · Cited by 37 · see citing works

Development of oral vaccines for human use.

Ar, F. (2000) · PubMed · Cited by 37 · see citing works

A Region of the Invasin Protein That Contributes to High Affinity Binding to Integrin Receptors

Saltman, L. H., Lu, Y., Zaharias, E. M., & Isberg, R. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.38.23438 · Cited by 36 · see citing works

Mucosal vaccination against bacterial respiratory infections

Baumann, U. (2008) · Expert Review of Vaccines · doi:10.1586/14760584.7.8.1257 · Cited by 36 · see citing works

Transgene vaccination using Ulex europaeus agglutinin I (UEA-1) for targeted mucosal immunization against HIV-1 envelope

Wang, X., Kochetkova, I., Haddad, A., Hoyt, T., Hone, D. M., & Pascual, D. W. (2005) · Vaccine · doi:10.1016/j.vaccine.2005.02.023 · Cited by 35 · see citing works

Mucosal Immunity to Vaccines: Current Concepts for Vaccine Development and Immune Response Analysis

McGhee, J. R., & Kiyono, H. (1992) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-3410-5_2 · Cited by 34 · see citing works

Induction of Broad Cross-Subtype-Specific HIV-1 Immune Responses by a Novel Multivalent HIV-1 Peptide Vaccine in Cynomolgus Macaques

Azizi, A., Anderson, D. E., Torres, J. V., Ogrel, A., Ghorbani, M., Soare, C., Sandstrom, P. A., Fournier, J., & Díaz‐Mitoma, F. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2174 · Cited by 33 · see citing works

Oral vaccination with LcrV from Yersinia pestis KIM delivered by live attenuated Salmonellaenterica serovar Typhimurium elicits a protective immune response against challenge with Yersinia pseudotuberculosis and Yersinia enterocolitica

Branger, C. G., Torres-Escobar, A., Sun, W., Perry, R. D., Fetherston, J. D., Roland, K. L., & Curtiss, R. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.06.078 · Cited by 33 · see citing works

Uptake of amplifiable fragments of retrotransposon DNA from the human alimentary tract

Forsman, A., Ushameckis, D., Bindra, A., Yun, Z., & Blomberg, J. (2003) · Molecular Genetics and Genomics · doi:10.1007/s00438-003-0930-3 · Cited by 33 · see citing works

Mucosal HIV vaccines: A holy grail or a dud?

Azizi, A., Ghunaim, H., Díaz‐Mitoma, F., & Mestecky, J. F. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.04.018 · Cited by 33 · see citing works

Characterisation of a live Salmonella vaccine stably expressing the Mycobacterium tuberculosis Ag85B–ESAT6 fusion protein

Hall, L. J., Clare, S., Pickard, D., Clark, S. O., Kelly, D. L. F., Ghany, M. A. E., Hale, C., Dietrich, J., Andersen, P. L., Marsh, P. D., et al. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.09.007 · Cited by 28 · see citing works

Impact of carriers in oral absorption: Permeation across Caco-2 cells for the organic anions estrone-3-sulfate and glipizide

Gram, L. K., Rist, G. M., Lennernäs, H., & Steffansen, B. (2009) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2009.03.008 · Cited by 24 · see citing works

Induction of T Helper Cells and Cytokines for Mucosal IgA Responses

Xu-Amano, J., Beagley, K. W., Mega, J., Fujihashi, K., Kiyono, H., & McGhee, J. R. (1992) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-3410-5_13 · Cited by 23 · see citing works

Viral peptide immunogens: current challenges and opportunities

Azizi, A., & Díaz‐Mitoma, F. (2007) · Journal of Peptide Science · doi:10.1002/psc.896 · Cited by 22 · see citing works

Delivery of plant-derived vaccines

Streatfield, S. J. (2005) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2.4.719 · Cited by 21 · see citing works

Activation and Regulation of Toll-like Receptor 9: CpGs and Beyond

Kindrachuk, J., Potter, J., Wilson, H. L., Griebel, P. J., Babiuk, L. A., & Napper, S. (2008) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955708784534481 · Cited by 18 · see citing works

Plant Production of Veterinary Vaccines and Therapeutics

Hammond, R. W., & Nemchinov, L. G. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-70868-1_5 · Cited by 14 · see citing works

Morphological Characteristics of the Heal Peyer's Patches in the Rhesus Macaque: a Histological and Ultrastructural Study

Kuhn, E.-M., & Kaup, F. ‐. (1996) · Anatomia Histologia Embryologia · doi:10.1111/j.1439-0264.1996.tb00061.x · Cited by 12 · see citing works

Mechanismen der Antigenaufnahme im Dünn- und Dickdarm: die Rolle der M-Zellen für die Initiierung von Immunantworten*

Gebert, A., Göke, M. N., Rothkötter, H. J., & Dietrich, C. F. (2000) · Zeitschrift für Gastroenterologie · doi:10.1055/s-2000-10001 · Cited by 12 · see citing works

Flavoridin inhibitsYersinia enterocoliticauptake into fibronectin-adherent HeLa cells

Scibelli, A., Matteoli, G., Roperto, S., Alimenti, E., Dipineto, L., Pavone, L. M., Morte, R. D., Menna, L. F., Fioretti, A., & Staiano, N. (2005) · FEMS Microbiology Letters · doi:10.1016/j.femsle.2005.04.024 · Cited by 11 · see citing works

The activity of lipopeptide TLR2 agonists critically depends on the presence of solubilizers

Voss, S., Ulmer, A. J., Jung, G., Wiesmüller, K., & Brock, R. E. (2007) · European Journal of Immunology · doi:10.1002/eji.200737537 · Cited by 8 · see citing works

[Adjuvant activity of lactic bacteria: perspectives for its use in oral vaccines].

Perdigón, G., Alvarez, S., de Macias, M. E. N., & Holgado, A. A. P. D. R. (1988) · PubMed · Cited by 8 · see citing works

Role of the polypeptide region of a 33 kDa mycobacterial lipoprotein for efficient IL-12 production

Yamashita, Y., Maeda, Y., Takeshita, F., Brennan, P. J., & Makino, M. (2004) · Cellular Immunology · doi:10.1016/j.cellimm.2004.06.001 · Cited by 7 · see citing works

[Bacterial vaccines for oral administration and local mechanisms of immunity].

Casini, E. (1974) · PubMed · Cited by 2 · see citing works

Comparative Efficacy of Influenza Vaccines

Narayan, K. M. V., & del Rı́o, C. (2010) · New England Journal of Medicine · doi:10.1056/nejmc0910674 · Cited by 2 · see citing works

Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals

Homayun, B., Lin, X., & Choi, H. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11030129 · Cited by 919 · see citing works

Recent progress in mucosal vaccine development: potential and limitations

Lycke, N. Y. (2012) · Nature reviews. Immunology · doi:10.1038/nri3251 · Cited by 815 · see citing works

Encapsulation, protection, and delivery of bioactive proteins and peptides using nanoparticle and microparticle systems: A review

McClements, D. J. (2018) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2018.02.002 · Cited by 469 · see citing works

Current state and challenges in developing oral vaccines

Ramirez, J. E. V., Sharpe, L. A., & Peppas, N. A. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.04.008 · Cited by 410 · see citing works

Status of vaccine research and development for Shigella

Mani, S., Wierzba, T. F., & Walker, R. I. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.02.075 · Cited by 230 · see citing works

Structure-function and application of plant lectins in disease biology and immunity

Mishra, A., Behura, A., Mawatwal, S., Kumar, A., Naik, L., Mohanty, S. S., Manna, D., Dokania, P., Mishra, A., Patra, S. K., et al. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.110827 · Cited by 229 · see citing works

Overcoming the intestinal barrier: A look into targeting approaches for improved oral drug delivery systems

Xu, Y., Shrestha, N., Véronique Préat, A., & Beloqui, A. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.04.006 · Cited by 215 · see citing works

Biodegradable polymers in drug delivery and oral vaccination

Jana, P., Shyam, M., Singh, S., Jayaprakash, V., & Dev, A. (2020) · European Polymer Journal · doi:10.1016/j.eurpolymj.2020.110155 · Cited by 180 · see citing works

Platforms for Production of Protein-Based Vaccines: From Classical to Next-Generation Strategies

Cid, R., & Bolívar, J. (2021) · Biomolecules · doi:10.3390/biom11081072 · Cited by 176 · see citing works

Oral delivery of nanoparticle-based vaccines

Marasini, N., Skwarczyński, M., & Tóth, I. (2014) · Expert Review of Vaccines · doi:10.1586/14760584.2014.936852 · Cited by 157 · see citing works

Mucosal vaccine delivery: Current state and a pediatric perspective

Shakya, A. K., Chowdhury, M. Y. E., Tao, W., & Gill, H. S. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.02.014 · Cited by 156 · see citing works

Mucosal vaccines and technology

Miquel-Clopés, A., Bentley, E. G., Stewart, J. P., & Carding, S. R. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13285 · Cited by 153 · see citing works

Subunit Vaccines of the Future: the Need for safe, Customized and Optimized Particulate Delivery Systems

Foged, C. (2011) · Therapeutic Delivery · doi:10.4155/tde.11.68 · Cited by 148 · see citing works

Targeted nanoparticles with novel non-peptidic ligands for oral delivery

Rieux, A. D., Pourcelle, V., Cani, P. D., Marchand‐Brynaert, J., & Véronique Préat, A. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.01.002 · Cited by 148 · see citing works

Recent Advances in Encapsulation, Protection, and Oral Delivery of Bioactive Proteins and Peptides using Colloidal Systems

Perry, S. L., & McClements, D. J. (2020) · Molecules · doi:10.3390/molecules25051161 · Cited by 148 · see citing works

Plant‐made oral vaccines against human infectious diseases—Are we there yet?

Chan, H., & Daniell, H. (2015) · Plant Biotechnology Journal · doi:10.1111/pbi.12471 · Cited by 146 · see citing works

Targeted oral delivery of BmpB vaccine using porous PLGA microparticles coated with M cell homing peptide-coupled chitosan

Jiang, T., Singh, B., Li, H.-S., Kim, Y.-K., Kang, S., Nah, J., Choi, Y., & Cho, C. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.073 · Cited by 143 · see citing works

The immunomodulatory effect of plant lectins: a review with emphasis on ArtinM properties

de Souza, M. A., Carvalho, F. C., Ruas, L. P., Ricci-Azevedo, R., & Roque‐Barreira, M. C. (2013) · Glycoconjugate Journal · doi:10.1007/s10719-012-9464-4 · Cited by 142 · see citing works

Alga-Produced Cholera Toxin-Pfs25 Fusion Proteins as Oral Vaccines

Gregory, J. A., Topol, A. B., Doerner, D. Z., & Mayfield, S. P. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.00714-13 · Cited by 132 · see citing works

The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles

García-Díaz, M., Birch, D., Wan, F., & Nielsen, H. M. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.11.002 · Cited by 120 · see citing works

Poly(Lactic Acid) and Poly(Lactic- Co -Glycolic Acid) Particles as Versatile Carrier Platforms for Vaccine Delivery

Pavot, V., Berthet, M., Rességuier, J., Legaz, S., Handké, N., Gilbert, S. C., Paul, S., & Verrier, B. (2014) · Nanomedicine · doi:10.2217/nnm.14.156 · Cited by 115 · see citing works

Application of Nano-Delivery Systems in Lymph Nodes for Tumor Immunotherapy

Xia, Y., Fu, S., Ma, Q., Liu, Y., & Zhang, N. (2023) · Nano-Micro Letters · doi:10.1007/s40820-023-01125-2 · Cited by 108 · see citing works

Towards tailored vaccine delivery: Needs, challenges and perspectives

Amorij, J., Kersten, G. F. A., Saluja, V., Tonnis, W. F., Hinrichs, W. L. J., Slütter, B., Bal, S. M., Bouwstra, J. A., Huckriede, A. L. W., & Jiskoot, W. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.12.039 · Cited by 102 · see citing works

The Role of CD103+ Dendritic Cells in the Intestinal Mucosal Immune System

Ruane, D., & Lavelle, E. C. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00025 · Cited by 101 · see citing works

Eudragit® L100-coated mannosylated chitosan nanoparticles for oral protein vaccine delivery

Xu, B., Zhang, W., Chen, Y., Xu, Y., Wang, B., & Zong, L. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.02.016 · Cited by 100 · see citing works

Enterocytes: active cells in tolerance to food and microbial antigens in the gut

Miron, N., & Cristea, V. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04523.x · Cited by 99 · see citing works

Mucosal Immune System and M Cell-targeting Strategies for Oral Mucosal Vaccination

Kim, S., Lee, K., & Jang, Y. (2012) · Immune Network · doi:10.4110/in.2012.12.5.165 · Cited by 98 · see citing works

Characterization and optimization of bilosomes for oral vaccine delivery

Wilkhu, J. S., McNeil, S. E., Anderson, D. E., & Perrie, Y. (2013) · Journal of drug targeting · doi:10.3109/1061186x.2012.747528 · Cited by 97 · see citing works

Antigen targeting to M cells for enhancing the efficacy of mucosal vaccines

Kim, S., & Jang, Y. (2014) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.165 · Cited by 96 · see citing works

Intranasal formulations: promising strategy to deliver vaccines

Riese, P., Sakthivel, P., Trittel, S., & Guzmán, C. A. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.931936 · Cited by 95 · see citing works

Oral drug delivery systems using chemical conjugates or physical complexes

Al-Hilal, T. A., Alam, F., & Byun, Y. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.11.002 · Cited by 93 · see citing works

Crossing the barrier: Targeting epithelial receptors for enhanced oral vaccine delivery

Devriendt, B., Geest, B. G. D., Goddeeris, B. M., & Cox, E. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.02.006 · Cited by 93 · see citing works

Intestinal absorption of insulin nanoparticles: Contribution of M cells

Lopes, M., Abrahim, B. A., Cabral, L. M., Rodrigues, C. R., Seiça, R. M. F., Veiga, F., & Ribeiro, A. J. (2014) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2014.02.014 · Cited by 92 · see citing works

Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity

Matsumura, T., Sugawara, Y., Yutani, M., Amatsu, S., Yagita∥, H., Kohda, T., Fukuoka, S.-I., Nakamura, Y., Fukuda, S., Hase, K., et al. (2015) · Nature Communications · doi:10.1038/ncomms7255 · Cited by 90 · see citing works

Roles of M cells in infection and mucosal vaccines

Wang, M., Gao, Z., Zhang, Z., Pan, L., & Zhang, Y. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.36174 · Cited by 90 · see citing works

Immune Tolerance for Autoimmune Disease and Cell Transplantation

Luo, X., Miller, S. D., & Shea, L. D. (2016) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-110315-020137 · Cited by 90 · see citing works

Plant‐based oral vaccines against zoonotic and non‐zoonotic diseases

Shahid, N., & Daniell, H. (2016) · Plant Biotechnology Journal · doi:10.1111/pbi.12604 · Cited by 90 · see citing works

Oral Vaccine Delivery for Intestinal Immunity—Biological Basis, Barriers, Delivery System, and M Cell Targeting

Kang, S. H., Hong, S. J., Lee, Y.-K., & Cho, S. (2018) · Polymers · doi:10.3390/polym10090948 · Cited by 86 · see citing works

Oral Deliverable Mucoadhesive Chitosan-Salmonella Subunit Nanovaccine for Layer Chickens

Renu, S., Markazi, A. D., Dhakal, S., Lakshmanappa, Y. S., Shanmugasundaram, R., Selvaraj, R. K., & Renukaradhya, G. J. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s238445 · Cited by 83 · see citing works

Surface-Modified P(HEMA- co -MAA) Nanogel Carriers for Oral Vaccine Delivery: Design, Characterization, and In Vitro Targeting Evaluation

Durán‐Lobato, M., Carrillo‐Conde, B., Khairandish, Y., & Peppas, N. A. (2014) · Biomacromolecules · doi:10.1021/bm500588x · Cited by 83 · see citing works

M cells expressing the complement C5a receptor are efficient targets for mucosal vaccine delivery

Kim, S., Jung, D., Yang, I., Kim, J., Lee, K., Nochi, T., Kiyono, H., & Jang, Y. (2011) · European Journal of Immunology · doi:10.1002/eji.201141592 · Cited by 80 · see citing works

Mucosal Immune Response in Nasal-Associated Lymphoid Tissue upon Intranasal Administration by Adjuvants

Takaki, H., Ichimiya, S., Matsumoto, M., & Seya, T. (2018) · Journal of Innate Immunity · doi:10.1159/000489405 · Cited by 79 · see citing works

Outer Membrane Vesicles Induce Immune Responses to Virulence Proteins and Protect against Colonization by Enterotoxigenic Escherichia coli

Roy, K., Hamilton, D. J., Munson, G. P., & Fleckenstein, J. M. (2011) · Clinical and Vaccine Immunology · doi:10.1128/cvi.05217-11 · Cited by 79 · see citing works

Ligand-mediated active targeting for enhanced oral absorption

Zhang, X., & Wu, W. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.03.001 · Cited by 78 · see citing works

Oral Helicobacter pylori vaccine-encapsulated acid-resistant HP55/PLGA nanoparticles promote immune protection

Tan, Z., Liu, W., Liu, H., Li, C., Zhang, Y., Meng, X., Tang, T., Xi, T., & Xing, Y. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.11.007 · Cited by 74 · see citing works

Spatiotemporal manipulation metal–organic frameworks as oral drug delivery systems for precision medicine

Wang, Z., Chen, J., Gao, R., Jiang, L., Zhang, G., Zhao, Y., Miao, Y., & Shi, Y. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215615 · Cited by 73 · see citing works

Advances and challenges in mucosal adjuvant technology

Newsted, D., Fallahi, F., Golshani, A., & Azizi, A. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.03.096 · Cited by 72 · see citing works

Transepithelial antigen delivery in the small intestine

Knoop, K. A., Miller, M. J., & Newberry, R. D. (2013) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32835cf1cd · Cited by 70 · see citing works

Chitosan-adjuvanted Salmonella subunit nanoparticle vaccine for poultry delivered through drinking water and feed

Renu, S., Han, Y., Dhakal, S., Lakshmanappa, Y. S., Ghimire, S., Feliciano-Ruiz, N., Senapati, S., Narasimhan, B., Selvaraj, R. K., & Renukaradhya, G. J. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116434 · Cited by 67 · see citing works

Rotavirus vaccine efficacy: current status and areas for improvement

Carvalho, M. F., & Gill, D. S. (2018) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2018.1520583 · Cited by 66 · see citing works

Surface Display of N-Terminally Anchored Invasin by Lactobacillus plantarum Activates NF-κB in Monocytes

Fredriksen, L., Kleiveland, C. R., Hult, L. T. O., Lea, T., Nygaard, C. S., Eijsink, V. G. H., & Mathiesen, G. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.01227-12 · Cited by 64 · see citing works

Vaccination against Salmonella Infection: the Mucosal Way

Gayet, R., Bioley, G., Rochereau, N., Paul, S., & Corthésy, B. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00007-17 · Cited by 64 · see citing works

M cell targeting engineered biomaterials for effective vaccination

Islam, M. A., Firdous, J., Badruddoza, A. Z. M., Reesor, E., Azad, M. A., Hasan, A., Lim, M., Cao, W., Guillemette, S. R., & Cho, C. S. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.10.041 · Cited by 64 · see citing works

High-Altitude-Induced alterations in Gut-Immune Axis: A review

Khanna, K., Mishra, K. P., Ganju, L., Kumar, B., & Singh, S. B. (2017) · International Reviews of Immunology · doi:10.1080/08830185.2017.1407763 · Cited by 55 · see citing works

Breaking the barricade of oral chemotherapy through polysaccharide nanocarrier

Dey, M., Das, M., Chowhan, A., & Giri, T. K. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.02.094 · Cited by 55 · see citing works

Characterization of immunogenicity of avian influenza antigens encapsulated in PLGA nanoparticles following mucosal and subcutaneous delivery in chickens

Alkie, T. N., Yitbarek, A., Taha-Abdelaziz, K., Astill, J., & Sharif, S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206324 · Cited by 53 · see citing works

Mucosal drug delivery: barriers, in vitro models and formulation strategies

Boegh, M., Foged, C., Müllertz, A., & Nielsen, H. M. (2013) · Journal of Drug Delivery Science and Technology · doi:10.1016/s1773-2247(13)50055-4 · Cited by 51 · see citing works

Nanostructured recombinant cytokines: A highly stable alternative to short-lived prophylactics

Torrealba, D., Parra, D., Seras‐Franzoso, J., Vallejos‐Vidal, E., Yero, D., Gibert, I., Villaverde, A., García‐Fruitós, E., & Roher, N. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.08.043 · Cited by 50 · see citing works

Surface engineered polyanhydride-based oral Salmonella subunit nanovaccine for poultry

Renu, S., Markazi, A. D., Dhakal, S., Lakshmanappa, Y. S., Gourapura, S., Shanmugasundaram, R., Senapati, S., Narasimhan, B., Selvaraj, R. K., & Renukaradhya, G. J. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s185588 · Cited by 47 · see citing works

Microcontainers as an oral delivery system for spray dried cubosomes containing ovalbumin

Nielsen, L. H., Rades, T., Boyd, B. J., & Boisen, A. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.12.008 · Cited by 46 · see citing works

Targeted Strategies for Mucosal Vaccination

Longet, S., Lundahl, M. L. E., & Lavelle, E. C. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00738 · Cited by 45 · see citing works

Oral targeted drug delivery to post-gastrointestinal sites

Han, R., He, H., Lü, Y., Lu, H., Shen, S., & Wu, W. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.04.047 · Cited by 46 · see citing works

In vitro and in vivo characterization of DNA delivery using recombinant Lactococcus lactis expressing a mutated form of L. monocytogenes Internalin A

de Azevedo, M. S. P., Karczewski, J., Lefèvre, F., Azevedo, V., Miyoshi, A., Wells, J. M., Langella, P., & Chatel, J. (2012) · BMC Microbiology · doi:10.1186/1471-2180-12-299 · Cited by 43 · see citing works

Exploiting or overcoming the dome trap for enhanced oral immunization and drug delivery

Qi, J., Zhuang, J., Lv, Y., Lü, Y., & Wu, W. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.02.021 · Cited by 43 · see citing works

The stomach, small intestine, and colon-specific gastrointestinal tract delivery systems for bioactive nutrients

Liang, S., Zhao, D., Liu, X., Liu, B., & Li, Y. (2025) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2025.103503 · Cited by 41 · see citing works

Targeting ideal oral vaccine vectors based on probiotics: a systematical view

Jiang, B., Li, Q., Ou, B., Duan, Q., & Zhu, G. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-09770-7 · Cited by 41 · see citing works

Oral delivery of probiotic expressing M cell homing peptide conjugated BmpB vaccine encapsulated into alginate/chitosan/alginate microcapsules

Jiang, T., Singh, B., Maharjan, S., Li, H.-S., Kang, S., Bok, J., Cho, C., & Choi, Y. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.07.003 · Cited by 41 · see citing works

Use of lectin-functionalized particles for oral immunotherapy

Diesner, S. C., Wang, X.-Y., Jensen-Jarolim, E., Untersmayr, E., & Gabor, F. (2012) · Therapeutic Delivery · doi:10.4155/tde.11.146 · Cited by 40 · see citing works

Spray dried cubosomes with ovalbumin and Quil-A as a nanoparticulate dry powder vaccine formulation

Laier, C. V. H., Gibson, B., van de Weert, M., Boyd, B. J., Rades, T., Boisen, A., Hook, S. M., & Nielsen, L. H. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.08.036 · Cited by 40 · see citing works

Application of an M-cell-targeting ligand for oral vaccination induces efficient systemic and mucosal immune responses against a viral antigen

Kim, S., Jung, D., Yang, I.-Y., Jang, S., Kim, J., Truong, T. T., Pham, T. V., Truong, N. U., Lee, K., & Jang, Y. (2013) · International Immunology · doi:10.1093/intimm/dxt029 · Cited by 36 · see citing works

New and Novel Approaches for Enhancing the Oral Absorption and Bioavailability of Protein and Peptides Therapeutics

Kanugo, A., & Misra, A. R. (2020) · Therapeutic Delivery · doi:10.4155/tde-2020-0068 · Cited by 35 · see citing works

Protein delivery by porous cationic maltodextrin-based nanoparticles into nasal mucosal cells: Comparison with cationic or anionic nanoparticles

Lê, M. Q., Carpentier, R., Lantier, I., Ducournau, C., Fasquelle, F., Dimier‐Poisson, I., & Betbeder, D. (2018) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2018.100001 · Cited by 34 · see citing works

Rational application of nanoadjuvant for mucosal vaccine delivery system

Dewangan, H. K. (2020) · Journal of Immunological Methods · doi:10.1016/j.jim.2020.112791 · Cited by 34 · see citing works

An insight into gastrointestinal macromolecule delivery using physical oral devices

Kaffash, E., Shahbazi, M., Hatami, H., & Nokhodchi, A. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.04.014 · Cited by 33 · see citing works

Animal vaccines based on orally presented yeast recombinants

Shin, M., & Yoo, H. S. (2013) · Vaccine · doi:10.1016/j.vaccine.2013.07.029 · Cited by 33 · see citing works

The Adjuvanticity of an O. volvulus-Derived rOv-ASP-1 Protein in Mice Using Sequential Vaccinations and in Non-Human Primates

Wang, J., Tricoche, N., Du, L., Hunter, M., Zhan, B., Goud, G. N., Didier, E. S., Liu, J., Lu, L., Marx, P. A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037019 · Cited by 32 · see citing works

Respiratory nanoparticle-based vaccines and challenges associated with animal models and translation

Renukaradhya, G. J., Narasimhan, B., & Mallapragada, S. K. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.09.047 · Cited by 30 · see citing works

Challenges and need of delivery carriers for bioactives and biological agents: an introduction

Yadav, D. K., Chauhan, N. S., Saraf, S., Singh, D., & Singh, M. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819666-3.00001-8 · Cited by 31 · see citing works

Immune System and Mechanism of Immunomodulation

Singh, M. R., Yadav, K., Chaurasiya, N. D., & Singh, D. (2022) · Springer eBooks · doi:10.1007/978-981-16-8117-2_1 · Cited by 30 · see citing works

Formulation and delivery of vaccines: Ongoing challenges for animal management

Hinds, L. A., & Sharma, S. (2012) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/0975-7406.103231 · Cited by 29 · see citing works

Roles of E4orf6 and VA I RNA in Adenovirus-Mediated Stimulation of Human Parvovirus B19 DNA Replication and Structural Gene Expression

Winter, K., von Kietzell, K., Heilbronn, R., Pozzuto, T., Fechner, H., & Weger, S. (2012) · Journal of Virology · doi:10.1128/jvi.06991-11 · Cited by 28 · see citing works

Nanovaccines : nanocarriers for antigen delivery

González-Aramúndiz, J. V., Cordeiro, A. S., Csaba, N., de la Fuente, M., & Alonso, M. J. (2012) · Biologie Aujourd hui · doi:10.1051/jbio/2012027 · Cited by 28 · see citing works

C5a receptor-targeting ligand-mediated delivery of dengue virus antigen to M cells evokes antigen-specific systemic and mucosal immune responses in oral immunization

Kim, S., Yang, I.-Y., Jang, S., Kim, J., Truong, T. T., Pham, T. V., Truong, N. U., Lee, K., & Jang, Y. (2013) · Microbes and Infection · doi:10.1016/j.micinf.2013.07.006 · Cited by 27 · see citing works

Trafficking and retention of protein antigens across systems and immune cell types

Doan, T. A., Forward, T. S., & Tamburini, B. A. J. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04303-4 · Cited by 24 · see citing works

Recent Developments in nanocarrier-aided Mucosal Vaccination

Kammona, O., Bourganis, V., Karamanidou, T., & Kiparissides, C. A. (2017) · Nanomedicine · doi:10.2217/nnm-2017-0015 · Cited by 25 · see citing works

Bacterial Endotoxins and Their Role in Periparturient Diseases of Dairy Cows: Mucosal Vaccine Perspectives

Eckel, E. F., & Ametaj, B. N. (2020) · Dairy · doi:10.3390/dairy1010006 · Cited by 26 · see citing works

Expression of Helicobacter pylori CagL gene in Lactococcus lactis MG1363 and evaluation of its immunogenicity as an oral vaccine in mice

Aliramaei, M. R., Khorasgani, M. R., Rahmani, A. M., Zarkesh‐Esfahani, S. H., & Emamzadeh, R. (2019) · Microbial Pathogenesis · doi:10.1016/j.micpath.2019.103926 · Cited by 23 · see citing works

Oral drug delivery for immunoengineering

Le, T. C., Aguilar, B., Mangal, J. L., & Acharya, A. P. (2021) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10243 · Cited by 22 · see citing works

The osmotic stress response of split influenza vaccine particles in an acidic environment

Choi, H., Kim, M., Kang, S., & Montemagno, C. D. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0257-5 · Cited by 22 · see citing works

Oral Immunogenicity in Mice and Sows of Enterotoxigenic Escherichia Coli Outer-Membrane Vesicles Incorporated into Zein-Based Nanoparticles

Matías, J., Brotons-Canto, A., Cenoz, S., Pérez, I., Abdulkarim, M., Gumbleton, M., Irache, J. M., & Gamazo, C. (2019) · Vaccines · doi:10.3390/vaccines8010011 · Cited by 22 · see citing works

Overview of the Advantages and Disadvantages of Different Mucosal Sites for the Delivery of Nanoparticles

Kaneko, K., Osman, N., Carini, V., Scagnetti, G., & Saleem, I. Y. (2020) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-030-35910-2_3 · Cited by 20 · see citing works

Bovine adenovirus-3 as a vaccine delivery vehicle

Ayalew, L. E., Kumar, P., Gaba, A., Makadiya, N., & Tikoo, S. K. (2014) · Vaccine · doi:10.1016/j.vaccine.2014.11.055 · Cited by 20 · see citing works

M cell specific markers in man and domestic animals: Valuable tools in vaccine development

Casteleyn, C. R., Broeck, W. V. D., Gebert, A., Tambuyzer, B. R., Cruchten, S. J. M. V., & Ginneken, C. J. V. (2013) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2013.03.002 · Cited by 20 · see citing works

Adaptive Immunity

Wherry, E. J., & Masopust, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800964-2.00005-7 · Cited by 19 · see citing works

Development of natural and unnatural amino acid delivery systems against hookworm infection

Bartlett, S., Skwarczyński, M., Xie, X., Tóth, I., Loukas, A. C., & Eichenberger, R. M. (2020) · Precision Nanomedicine · doi:10.33218/prnano3(1).191210.1 · Cited by 19 · see citing works

A Mechanistic Study on the Destabilization of Whole Inactivated Influenza Virus Vaccine in Gastric Environment

Choi, H., Ebersbacher, C. F., Kim, M., Kang, S., & Montemagno, C. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066316 · Cited by 19 · see citing works

Mucosal Lactobacillus vectored vaccines

Yu, Q., Zhu, L., Kang, H., & Yang, Q. (2013) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.23302 · Cited by 19 · see citing works

Mannose-specific plant and microbial lectins as antiviral agents: A review

Gupta, A., Yadav, K., Yadav, A., Ahmad, R., Srivastava, A., Kumar, D., Khan, M. A., & Dwivedi, U. N. (2024) · Glycoconjugate Journal · doi:10.1007/s10719-023-10142-7 · Cited by 18 · see citing works

Mucosal vaccination--an old but still vital strategy.

Długońska, H., & Grzybowski, M. M. (2012) · PubMed · Cited by 18 · see citing works

Oral Immunotherapy Using Polymeric Nanoparticles Loaded with Peanut Proteins in a Murine Model of Fatal Anaphylaxis

Gamazo, C., García-Azpíroz, M., Rebouças, J. D. S., Gastaminza, G., Ferrer, M., & Irache, J. M. (2017) · Immunotherapy · doi:10.2217/imt-2017-0111 · Cited by 18 · see citing works

Advantages and Challenges Surrounding Mucosal

Cells, M., Azizi, A., Kumar, A., Diaz-mitoma, F., & Mestecky, J. (2013)

Present Scenario of M-Cell Targeting Ligands for Oral Mucosal Immunization

Saraf, S. K., Jain, S. V., Sahoo, R. N., & Mallick, S. (2020) · Current Drug Targets · doi:10.2174/1389450121666200609113252 · Cited by 8 · see citing works

Optimisation of Oral Immunization Through Receptor-Mediated Targeting of M Cells

Foxwell, A. R., Cripps, A. W., & Kyd, J. M. (2007) · Human Vaccines · doi:10.4161/hv.3.5.4358 · Cited by 11 · see citing works

Oral Vaccine Delivery for Intestinal Immunity—Biological Basis, Barriers, Delivery System, and M Cell Targeting

Kang, S. H., Hong, S. J., Lee, Y.-K., & Cho, S. (2018) · Polymers · doi:10.3390/polym10090948 · Cited by 86 · see citing works

Mucosal Immune System and M Cell-targeting Strategies for Oral Mucosal Vaccination

Kim, S., Lee, K., & Jang, Y. (2012) · Immune Network · doi:10.4110/in.2012.12.5.165 · Cited by 98 · see citing works