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A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits
Abstract
Receptor-mediated activation of heterotrimeric guanine nucleotide-binding proteins (G proteins) results in the dissociation of α from βγ subunits, thereby allowing both to regulate effectors. Little is known about the regions of effectors required for recognition of Gβγ. A peptide encoding residues 956 to 982 of adenylyl cyclase 2 specifically blocked Gβγ stimulation of adenylyl cyclase 2, phospholipase C-β3, potassium channels, and β-adrenergic receptor kinase as well as inhibition of calmodulin-stimulated adenylyl cyclases, but had no effect on interactions between Gβγ and Gα o . Substitutions in this peptide identified a functionally important motif, Gln-X-X-Glu-Arg, that is also conserved in regions of potassium channels and β-adrenergic receptor kinases that participate in Gβγ interactions. Thus, the region defined by residues 956 to 982 of adenylyl cyclase 2 may contain determinants important for receiving signals from Gβγ.
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Citations
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Complexity and Diversity of Mammalian Adenylyl Cyclases
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Ostrom, K. F., LaVigne, J. E., Brust, T. F., Seifert, R., Dessauer, C. W., Watts, V. J., & Ostrom, R. S. (2022) · Physiological Reviews · doi:10.1152/physrev.00013.2021 · Cited by 131
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Metadata
- Authors
- Chen, J., DeVivo, M., Dingus, J., Harry, A., Li, J., Sui, J., Carty, D. J., Blank, J. L., Exton, J. H., Stoffel, R. H., Inglese, J., Lefkowitz, R. J., Logothetis, D. E., Hildebrandt, J. D., & lyengar, R.
- Venue
- Science
- Published
- 1995-05-26
- Volume
- 268
- Issue
- 5214
- Pages
- 1166-1169
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2150888122
- Cited by
- 277
- References
- 2
- FWCI
- 12.43
- Type
- journal article
- Language
- en
- Open access
- closed
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