The DOI matches its Crossref record.
ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists
Abstract
Small changes in the peptide-major histocompatibility complex (MHC) molecule ligands recognized by antigen-specific T cell receptors (TCRs) can convert fully activating complexes into partially activating or even inhibitory ones. This study examined early TCR-dependent signals induced by such partial agonists or antagonists. In contrast to typical agonist ligands, both an antagonist and several partial agonists stimulated a distinct pattern of ζ chain phosphorylation and failed to activate associated ZAP-70 kinase. These results identify a specific step in the early tyrosine phosphorylation cascade that is altered after TCR engagement with modified peptide-MHC molecule complexes. This finding may explain the different biological responses to TCR occupancy by these variant ligands.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Positive and negative selection of T cells
Starr, T. K., Jameson, S. C., & Hogquist, K. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141107 · Cited by 1,601
TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
Štefanová, I., Hemmer, B., Vergelli, M., Martin, R., Biddison, W. E., & Germain, R. N. (2003) · Nature Immunology · doi:10.1038/ni895 · Cited by 465
Self-citationStructural Basis for the Inhibition of Tyrosine Kinase Activity of ZAP-70
Deindl, S., Kadlecek, T. A., Brdicka, T., Cao, X., Weiss, A., & Kuriyan, J. (2007) · Cell · doi:10.1016/j.cell.2007.03.039 · Cited by 234
Glucocorticoids Attenuate T Cell Receptor Signaling
Van Laethem, F., Baus, E., Smyth, L. A., Andris, F., Bex, F., Urbain, J., Kioussis, D., & Leo, O. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.7.803 · Cited by 118
Proximity and orientation underlie signaling by the non‐receptor tyrosine kinase ZAP70
Graef, I. A., Holsinger, L. J., Diver, S., Schreiber, S. L., & Crabtree, G. R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.18.5618 · Cited by 67
Metadata
- Authors
- Madrenas, J., Wange, R. L., Wang, J. L., Isakov, N., Samelson, L. E., & Germain, R. N.
- Venue
- Science
- Published
- 1995-01-27
- Volume
- 267
- Issue
- 5197
- Pages
- 515-518
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2095433140
- Cited by
- 505
- References
- 0
- FWCI
- 28.41
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists. https://app.cochat.ai/papers/10.1126/science.7824949
- The paper
- Madrenas, J., Wange, R. L., Wang, J. L., Isakov, N., Samelson, L. E., & Germain, R. N. (1995). ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists. Science. https://doi.org/10.1126/science.7824949
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
