Cited by 1,601T-cell and B-cell ImmunologyImmunotherapy and Immune Responsesvaccines and immunoinformatics approaches

Positive and negative selection of T cells

Starr, Timothy K., Jameson, Stephen C., Hogquist, Kristin A.·2003·Annual Review of Immunology

Abstract

A functional immune system requires the selection of T lymphocytes expressing receptors that are major histocompatibility complex restricted but tolerant to self-antigens. This selection occurs predominantly in the thymus, where lymphocyte precursors first assemble a surface receptor. In this review we summarize the current state of the field regarding the natural ligands and molecular factors required for positive and negative selection and discuss a model for how these disparate outcomes can be signaled via the same receptor. We also discuss emerging data on the selection of regulatory T cells. Such cells require a high-affinity interaction with self-antigens, yet differentiate into regulatory cells instead of being eliminated.

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Crossref · 10.1146/annurev.immunol.21.120601.141107

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240 of 240 references verified0 citation errors · 0 not checkable

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  • Regulatory T-cells suppress autoimmunity through active targeting of autoreactive T-cells that are erroneously present in the periphery.

    “T regs suppress autoimmunity through active targeting of autoreactive T-cells that are erroneously present in the periphery [82].”

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Authors
Starr, T. K., Jameson, S. C., & Hogquist, K. A.
Affiliations
University of Minnesota (US)
Venue
Annual Review of Immunology
Published
2003-04
Volume
21
Issue
1
Pages
139-176
ISSN
  • 0732-0582 (ISSN-L)
  • 1545-3278
OpenAlex
W2114569569
Cited by
1,601
References
240
Citations by year
2026: 18 · 2025: 24 · 2024: 42 · 2023: 42 · 2022: 53 · 2021: 69 · 2020: 61 · 2019: 41 · 2018: 63 · 2017: 61 · 2016: 64 · 2015: 63 · 2014: 82 · 2013: 90 · 2012: 82
FWCI
7.47
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
Keywords
T cell selection, positive selection, negative selection, thymus, T cell receptor, major histocompatibility complex, self-tolerance, autoantigens, regulatory T cells
MeSH terms
Animals, Cell Differentiation, Epithelial Cells, Humans, Receptors, Antigen, T-Cell, T-Lymphocytes, Thymus Gland, Transcription Factors, Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor, Signal Transduction, Clonal Deletion, Models, Immunological, Mice

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