The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Roles of N-Type and Q-Type Ca 2+ Channels in Supporting Hippocampal Synaptic Transmission
Abstract
Several types of calcium channels found in the central nervous system are possible participants in triggering neurotransmitter release. Synaptic transmission between hippocampal CA3 and CA1 neurons was mediated by N-type calcium channels, together with calcium channels whose pharmacology differs from that of L- and P-type channels but resembles that of the Q-type channel encoded by the α 1A subunit gene. Blockade of either population of channels strongly increased enhancement of synaptic transmission with repetitive stimuli. Even after complete blockade of N-type channels, transmission was strongly modulated by stimulation of neurotransmitter receptors or protein kinase C. These findings suggest a role for α 1A subunits in synaptic transmission and support the idea that neurotransmitter release may depend on multiple types of calcium channels under physiological conditions.
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Citations
Cites
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Multiple types of neuronal calcium channels and their selective modulation
Tsien, R. W., Lipscombe, D., Madison, D. V., Bley, K. R., & Fox, A. P. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90194-4 · Cited by 1,381
Self-citation
Cited by
Liao, D., Hessler, N. A., & Malinow, R. (1995) · Nature · doi:10.1038/375400a0 · Cited by 1,365
13 reasons why the brain is susceptible to oxidative stress
Cobley, J. N., Fiorello, M. L., & Bailey, D. M. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.008 · Cited by 1,215
Burgoyne, R. D., & Morgan, A. (2003) · Physiological Reviews · doi:10.1152/physrev.00031.2002 · Cited by 934
Exocytotic Ca2+ channels in mammalian central neurons
Dunlap, K., Luebke, J. I., & Turner, T. J. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)80030-6 · Cited by 915
Excitation-Neurogenesis Coupling in Adult Neural Stem/Progenitor Cells
Deisseroth, K., Singla, S., Toda, H., Monje, M., Palmer, T. D., & Malenka, R. C. (2004) · Neuron · doi:10.1016/s0896-6273(04)00266-1 · Cited by 674
Metadata
- Authors
- Wheeler, D. B., Randall, A., & Tsien, R. W.
- Venue
- Science
- Published
- 1994-04
- Volume
- 264
- Issue
- 5155
- Pages
- 107-111
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1988937009
- Cited by
- 949
- References
- 2
- FWCI
- 31.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Roles of N-Type and Q-Type Ca 2+ Channels in Supporting Hippocampal Synaptic Transmission. https://app.cochat.ai/papers/10.1126/science.7832825
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- Wheeler, D. B., Randall, A., & Tsien, R. W. (1994). Roles of N-Type and Q-Type Ca 2+ Channels in Supporting Hippocampal Synaptic Transmission. Science. https://doi.org/10.1126/science.7832825
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
