The DOI matches its Crossref record.
Casein Kinase IIα Transgene-Induced Murine Lymphoma: Relation to Theileriosis in Cattle
Abstract
Infection of cattle with the protozoan parasite Theileria parva results in a fatal lymphoproliferative syndrome that is associated with the overexpression of casein kinase II. The role of this enzyme in the pathogenesis of lymphoproliferative disorders was investigated by expressing the catalytic subunit in lymphocytes of transgenic mice. Adult transgenic mice displayed a stochastic propensity to develop lymphoma; co-expression of a c- myc transgene in addition to casein kinase II resulted in neonatal leukemia. Thus, the casein kinase II gene can serve as an oncogene, and its dysregulated expression is capable of transforming lymphocytes in a two-step pathway with c- myc .
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Citations
Cited by
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
Traenckner, E. B., Pahl, H. L., Henkel, T., Schmidt, K. N., Wilk, S., & Baeuerle, P. A. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07287.x · Cited by 1,013
Wang, D., Westerheide, S. D., Hanson, J. L., & Baldwin, A. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001358200 · Cited by 454
Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme
Niefind, K. (2001) · The EMBO Journal · doi:10.1093/emboj/20.19.5320 · Cited by 444
Globozoospermia in mice lacking the casein kinase II α′ catalytic subunit
Xu, X., Toselli, P. A., Russell, L. D., & Seldin, D. C. (1999) · Nature Genetics · doi:10.1038/12729 · Cited by 400
Self-citation
Metadata
- Authors
- Seldin, D. C., & Leder, P.
- Venue
- Science
- Published
- 1995-02-10
- Volume
- 267
- Issue
- 5199
- Pages
- 894-897
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2068229957
- Cited by
- 395
- References
- 0
- FWCI
- 7.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Casein Kinase IIα Transgene-Induced Murine Lymphoma: Relation to Theileriosis in Cattle. https://app.cochat.ai/papers/10.1126/science.7846532
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- Seldin, D. C., & Leder, P. (1995). Casein Kinase IIα Transgene-Induced Murine Lymphoma: Relation to Theileriosis in Cattle. Science. https://doi.org/10.1126/science.7846532
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
