The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD
Abstract
Skeletal muscle differentiation entails the coordination of muscle-specific gene expression and terminal withdrawal from the cell cycle. This cell cycle arrest in the G0 phase requires the retinoblastoma tumor suppressor protein (Rb). The function of Rb is negatively regulated by cyclin-dependent kinases (Cdks), which are controlled by Cdk inhibitors. Expression of MyoD, a skeletal muscle-specific transcriptional regulator, activated the expression of the Cdk inhibitor p21 during differentiation of murine myocytes and in nonmyogenic cells. MyoD-mediated induction of p21 did not require the tumor suppressor protein p53 and correlated with cell cycle withdrawal. Thus, MyoD may induce terminal cell cycle arrest during skeletal muscle differentiation by increasing the expression of p21.
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Cites
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Cited by
Giancotti, F. G., & Ruoslahti, E. (1999) · Science · doi:10.1126/science.285.5430.1028 · Cited by 3,869
Satellite Cells and the Muscle Stem Cell Niche
Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
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NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1
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Metadata
- Authors
- Halevy, O., Novitch, B. G., Spicer, D. B., Skapek, S. X., Rhee, J., Hannon, G. J., Beach, D., & Lassar, A. B.
- Venue
- Science
- Published
- 1995-02-17
- Volume
- 267
- Issue
- 5200
- Pages
- 1018-1021
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2052651806
- Cited by
- 1,149
- References
- 5
- FWCI
- 43.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Halevy, O., Novitch, B. G., Spicer, D. B., Skapek, S. X., Rhee, J., Hannon, G. J., Beach, D., & Lassar, A. B. (1995). Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD. Science. https://doi.org/10.1126/science.7863327
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
