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Cardiac Malformation in Neonatal Mice Lacking Connexin43
Abstract
Gap junctions are made up of connexin proteins, which comprise a multigene family in mammals. Targeted mutagenesis of connexin43 (Cx43), one of the most prevalent connexin proteins, showed that its absence was compatible with survival of mouse embryos to term, even though mutant cell lines showed reduced dye coupling in vitro. However, mutant embryos died at birth, as a result of a failure in pulmonary gas exchange caused by a swelling and blockage of the right ventricular outflow tract from the heart. This finding suggests that Cx43 plays an essential role in heart development but that there is functional compensation among connexins in other parts of the developing fetus.
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Citations
Cited by
Gap junctions and the connexin protein family
SOHL, G. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.11.013 · Cited by 991
Female infertility in mice lacking connexin 37
Simon, A. M., Goodenough, D. A., Li, E., & Paul, D. L. (1997) · Nature · doi:10.1038/385525a0 · Cited by 733
Molecular Pathways Controlling Heart Development
Olson, E. N., & Srivastava, D. (1996) · Science · doi:10.1126/science.272.5262.671 · Cited by 478
Lecanda, F., Warlow, P. M., Sheikh, S., Furlan, F., Steinberg, T. H., & Civitelli, R. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.4.931 · Cited by 395
Bivi, N., Condon, K. W., Allen, M. R., Farlow, N., Passeri, G., Brun, L. R., Rhee, Y., Bellido, T., & Plotkin, L. I. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.548 · Cited by 261
“Willecke, Universitat Bonn, Bonn, Germany, or Cx43þ/ mice,((26)) generated by J.”
Metadata
- Authors
- Reaume, A. G., de Sousa, P. A., Kulkarni, S., Langille, B. L., Zhu, D., Davies, T. C., Juneja, S. C., Kidder, G. M., & Rossant, J.
- Venue
- Science
- Published
- 1995-03-24
- Volume
- 267
- Issue
- 5205
- Pages
- 1831-1834
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2098872610
- Cited by
- 1,244
- References
- 0
- FWCI
- 18.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Reaume, A. G., de Sousa, P. A., Kulkarni, S., Langille, B. L., Zhu, D., Davies, T. C., Juneja, S. C., Kidder, G. M., & Rossant, J. (1995). Cardiac Malformation in Neonatal Mice Lacking Connexin43. Science. https://doi.org/10.1126/science.7892609
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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