The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
FGF-2: Apical Ectodermal Ridge Growth Signal for Chick Limb Development
Abstract
The apical ectodermal ridge permits growth and elongation of amniote limb buds; removal causes rapid changes in mesodermal gene expression, patterned cell death, and truncation of the limb. Ectopic fibroblast growth factor (FGF)-2 supplied to the chick apical bud mesoderm after ridge removal will sustain normal gene expression and cell viability, and allow relatively normal limb development. A bioassay for FGFs demonstrated that FGF-2 was the only detectable FGF in chick limb bud extracts. By distribution and bioactivity, FGF-2 is the prime candidate for the chick limb bud apical ridge growth signal.
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Citations
Cites
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The proximo‐distal sequence of origin of the parts of the chick wing and the role of the ectoderm
Saunders, J. W. (1948) · Journal of Experimental Zoology · doi:10.1002/jez.1401080304 · Cited by 1,092
Positional Information in Chick Limb Morphogenesis
SUMMERBELL, D., LEWIS, J. H., & WOLPERT, L. (1973) · Nature · doi:10.1038/244492a0 · Cited by 708
FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb
Niswander, L., Tickle, C., Vogel, A., Booth, I., & Martin, G. R. (1993) · Cell · doi:10.1016/0092-8674(93)90391-3 · Cited by 653
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FGF-4 and BMP-2 have opposite effects on limb growth
Niswander, L., & Martin, G. R. (1993) · Nature · doi:10.1038/361068a0 · Cited by 377
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Self-citationEctoderm — mesoderm relationship in the development of the chick embryo limb bud
Zwilling, E. (1955) · Journal of Experimental Zoology · doi:10.1002/jez.1401280304 · Cited by 179
Distribution of FGF‐2 suggests it has a role in chick limb bud growth
Savage, M. P., Fallon, J. F., Hart, C. E., Riley, B. B., Sasse, J., & Olwin, B. B. (1993) · Developmental Dynamics · doi:10.1002/aja.1001980302 · Cited by 141
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Self-citation
Cited by
Fibroblast growth factors, their receptors and signaling
Powers, C. J., McLeskey, S. W., & Wellstein, A. (2000) · Endocrine-related cancer · doi:10.1677/erc.0.0070165 · Cited by 1,332
Laufer, E., Nelson, C. E., Johnson, R. L., Morgan, B. A., & Tabin, C. (1994) · Cell · doi:10.1016/0092-8674(94)90030-2 · Cited by 803
1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Notochord repression of endodermal Sonic hedgehog permits pancreas development
Hebrok, M., Kim, S. K., & Melton, D. A. (1998) · Genes & Development · doi:10.1101/gad.12.11.1705 · Cited by 628
Molecular Models for Vertebrate Limb Development
Johnson, R. L., & Tabin, C. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80364-5 · Cited by 580
Metadata
- Authors
- Fallon, J. F., López, A., Ros, M. A., Savage, M. P., Olwin, B. B., & Simandl, B. K.
- Venue
- Science
- Published
- 1994-04
- Volume
- 264
- Issue
- 5155
- Pages
- 104-107
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2068742932
- Cited by
- 455
- References
- 19
- FWCI
- 16.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: FGF-2: Apical Ectodermal Ridge Growth Signal for Chick Limb Development. https://app.cochat.ai/papers/10.1126/science.7908145
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- Fallon, J. F., López, A., Ros, M. A., Savage, M. P., Olwin, B. B., & Simandl, B. K. (1994). FGF-2: Apical Ectodermal Ridge Growth Signal for Chick Limb Development. Science. https://doi.org/10.1126/science.7908145
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
