The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Gem: an Induced, Immediate Early Protein Belonging to the Ras Family
Abstract
A gene encoding a 35-kilodalton guanosine triphosphate (GTP)-binding protein, Gem, was cloned from mitogen-induced human peripheral blood T cells. Gem and Rad, the product of a gene overexpressed in skeletal muscle in individuals with Type II diabetes, constitute a new family of Ras-related GTP-binding proteins. The distinct structural features of this family include the G3 GTP-binding motif, extensive amino- and carboxyl-terminal extensions beyond the Ras-related domain, and a motif that determines membrane association. Gem was transiently expressed in human peripheral blood T cells in response to mitogenic stimulation; the protein was phosphorylated on tyrosine residues and localized to the cytosolic face of the plasma membrane. Deregulated Gem expression prevented proliferation of normal and transformed 3T3 cells. These results suggest that Gem is a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A few small GTPases containing substitutions at one or two of these positions have been found to maintain and exhibit GTPase activity in spite of the difference (37, 49).”
From The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function (2002) · cites this paper as [37]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The GTPase superfamily: conserved structure and molecular mechanism
Bourne, H. R., Sanders, D. A., & McCormick, F. (1991) · Nature · doi:10.1038/349117a0 · Cited by 3,392
Research works printed but not linked: 16
- ANDREWS, P.W., PLURIPOTENT EMBRYONAL CARCINOMA CLONES DERIVED FROM THE HUMAN TERATOCARCINOMA CELL-LINE TERA-2 - DIFFERENTIATION INVIVO AND INVITRO, LABORATORY INVESTIGATION 50: 147 (1984).
- BARBACID, M, CELLULAR-TRANSFORMATION BY SUBGENOMIC FELINE SARCOMA-VIRUS DNA, JOURNAL OF VIROLOGY 37: 518 (1981). · DOI
- 10.1038/366643a0 · DOI
- DER, C.J., BIOLOGICAL AND BIOCHEMICAL-PROPERTIES OF HUMAN RASH GENES MUTATED AT CODON-61, CELL 44: 167 (1986). · DOI
- FLETCHER, B.S., STRUCTURE AND EXPRESSION OF TIS21, A PRIMARY RESPONSE GENE INDUCED BY GROWTH-FACTORS AND TUMOR PROMOTERS, JOURNAL OF BIOLOGICAL CHEMISTRY 266: 14511 (1991). · DOI
- GERRARD, T.L., DIFFERENTIAL EFFECT OF MONOCLONAL ANTI-DR ANTIBODY ON MONOCYTES IN ANTIGEN-STIMULATED AND MITOGEN-STIMULATED RESPONSES - MECHANISM OF INHIBITION AND RELATIONSHIP TO INTERLEUKIN-1 SECRETION, CELLULAR IMMUNOLOGY 82: 394 (1983). · DOI
- GUNNING, P, ISOLATION AND CHARACTERIZATION OF FULL-LENGTH CDNA CLONES FOR HUMAN ALPHA-ACTIN, BETA-ACTIN AND GAMMA-ACTIN MESSENGER-RNAS - SKELETAL BUT NOT CYTOPLASMIC ACTINS HAVE AN AMINO-TERMINAL CYSTEINE THAT IS SUBSEQUENTLY REMOVED, MOLECULAR AND CELLULAR BIOLOGY 3: 787 (1983).
- 10.1016/0092-8674(89)90054-8 · DOI
- Hwang, Y. W., The Guanine-Nucleotide Binding Proteins: Common Structural and Functional Properties: 77 (1989).
- JAHNER, D, THE RAS-RELATED GENE RHOB IS AN IMMEDIATE-EARLY GENE INDUCIBLE BY V-FPS, EPIDERMAL GROWTH-FACTOR, AND PLATELET-DERIVED GROWTH-FACTOR IN RAT FIBROBLASTS, MOLECULAR AND CELLULAR BIOLOGY 11: 3682 (1991).
- KOLCH, W, RAF-1 PROTEIN-KINASE IS REQUIRED FOR GROWTH OF INDUCED NIH/3T3 CELLS, NATURE 349: 426 (1991). · DOI
- MILLER, R.T., A MUTATION THAT PREVENTS GTP-DEPENDENT ACTIVATION OF THE ALPHA-CHAIN OF GS, NATURE 334: 712 (1988). · DOI
- 10.1002/j.1460-2075.1990.tb07409.x · DOI
- 10.1126/science.8248782 · DOI · Paper page
- SEKIYA, T, MOLECULAR-CLONING AND THE TOTAL NUCLEOTIDE-SEQUENCE OF THE HUMAN C-HA-RAS-1 GENE ACTIVATED IN A MELANOMA FROM A JAPANESE PATIENT, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 81: 4771 (1984).
- ZIPFEL, P.F., COMPLEXITY OF THE PRIMARY GENETIC RESPONSE TO MITOGENIC ACTIVATION OF HUMAN T-CELLS, MOLECULAR AND CELLULAR BIOLOGY 9: 1041 (1989).
Cited by
Li, X., Bu, X., Lu, B., Avraham, H., Flavell, R. A., & Lim, B. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1158-1171.2002 · Cited by 153
Effects of Novelty Stress on Hippocampal Gene Expression, Corticosterone and Motor Activity in Mice
Kurumaji, A., Umino, M., & Nishikawa, T. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.06.006 · Cited by 18
Metadata
- Authors
- Maguire, J., Santoro, T., Jensen, P., Siebenlist, U., Yewdell, J., & Kelly, K.
- Affiliations
- Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
- Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- Venue
- Science
- Published
- 1994-07-08
- Volume
- 265
- Issue
- 5169
- Pages
- 241-244
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 152
- References
- 1
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Gem: an Induced, Immediate Early Protein Belonging to the Ras Family. https://app.cochat.ai/papers/10.1126/science.7912851
- The paper
- Maguire, J., Santoro, T., Jensen, P., Siebenlist, U., Yewdell, J., & Kelly, K. (1994). Gem: an Induced, Immediate Early Protein Belonging to the Ras Family. Science. https://doi.org/10.1126/science.7912851
