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Cited by 1,205

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

BRCA1 Mutations in Primary Breast and Ovarian Carcinomas

Futreal, P. Andrew, Liu, Qingyun, Shattuck-Eidens, Donna, Cochran, Charles, Harshman, Keith, Tavtigian, Sean, Bennett, L. Michelle, Haugen-Strano, Astrid, Swensen, Jeff, Miki, Yoshio, Eddington, Ken, McClure, Melody, Frye, Cheryl, Weaver-Feldhaus, Jane, Ding, Wei, Gholami, Zahra, Söderkvist, Peter, Terry, Lori, Jhanwar, Suresh, Berchuck, Andrew, Iglehart, J. Dirk, Marks, Jeff, Ballinger, Dennis G., Barrett, J. Carl, Skolnick, Mark H., Kamb, Alexander, Wiseman, Roger·1994·Science
DOI 10.1126/science.7939630
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Abstract

Loss of heterozygosity data from familial tumors suggest that BRCA1 , a gene that confers susceptibility to ovarian and early-onset breast cancer, encodes a tumor suppressor. The BRCA1 region is also subject to allelic loss in sporadic breast and ovarian cancers, an indication that BRCA1 mutations may occur somatically in these tumors. The BRCA1 coding region was examined for mutations in primary breast and ovarian tumors that show allele loss at the BRCA1 locus. Mutations were detected in 3 of 32 breast and 1 of 12 ovarian carcinomas; all four mutations were germline alterations and occurred in early-onset cancers. These results suggest that mutation of BRCA1 may not be critical in the development of the majority of breast and ovarian cancers that arise in the absence of a mutant germline allele.

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Research works printed but not linked: 18

  1. CROPP, C.S., IDENTIFICATION OF 3 REGIONS ON CHROMOSOME-17Q IN PRIMARY HUMAN BREAST CARCINOMAS WHICH ARE FREQUENTLY DELETED, CANCER RESEARCH 53: 5617 (1993).
  2. CROPP, C.S., EVIDENCE FOR INVOLVEMENT OF BRCA1 IN SPORADIC BREAST CARCINOMAS, CANCER RESEARCH 54: 2548 (1994).
  3. EASTON, D.F., GENETIC-LINKAGE ANALYSIS IN FAMILIAL BREAST AND OVARIAN-CANCER - RESULTS FROM 214 FAMILIES, AMERICAN JOURNAL OF HUMAN GENETICS 52: 678 (1993).
  4. ECCLES, D.M., ALLELE LOSSES ON CHROMOSOME-17 IN HUMAN EPITHELIAL OVARIAN-CARCINOMA, ONCOGENE 5: 1599 (1990).
  5. FUTREAL, P.A., DETECTION OF FREQUENT ALLELIC LOSS ON PROXIMAL CHROMOSOME-17Q IN SPORADIC BREAST-CARCINOMA USING MICROSATELLITE LENGTH POLYMORPHISMS, CANCER RESEARCH 52: 2624 (1992).
  6. FUTREAL, P.A., ISOLATION OF A DIVERGED HOMEOBOX GENE, MOX1, FROM THE BRCA1 REGION ON 17Q21 BY SOLUTION HYBRID CAPTURE, HUMAN MOLECULAR GENETICS 3: 1359 (1994). · DOI
  7. GLEBOV, O.K., FREQUENT P53 GENE-MUTATIONS AND NOVEL ALLELES IN FAMILIAL BREAST-CANCER, CANCER RESEARCH 54: 3703 (1994).
  8. 10.1126/science.2270482 · DOI · Paper page
  9. JACOBS, I.J., A DELETION UNIT ON CHROMOSOME-17Q IN EPITHELIAL OVARIAN-TUMORS DISTAL TO THE FAMILIAL BREAST OVARIAN-CANCER LOCUS, CANCER RESEARCH 53: 1218 (1993).
  10. KELSELL, D.P., GENETIC-ANALYSIS OF THE BRCA1 REGION IN A LARGE BREAST OVARIAN FAMILY - REFINEMENT OF THE MINIMAL REGION CONTAINING BRCA1, HUMAN MOLECULAR GENETICS 2: 1823 (1993). · DOI
  11. KNUDSON, A.G., RETINOBLASTOMA - PROTOTYPIC HEREDITARY NEOPLASM, SEMINARS IN ONCOLOGY 5: 57 (1978).
  12. LYNCH, H.T., HEREDITARY CARCINOMA OF THE OVARY AND ASSOCIATED CANCERS - A STUDY OF 2 FAMILIES, GYNECOLOGIC ONCOLOGY 36: 48 (1990). · DOI
  13. 10.1126/science.7545954 · DOI
  14. MIYOSHI, Y, HUM MOL GENET 1: 229 (1992). · DOI · Paper page
  15. SAITO, H, DETAILED DELETION MAPPING OF CHROMOSOME 17Q IN OVARIAN AND BREAST CANCERS - 2-CM REGION ON 17Q21.3 OFTEN AND COMMONLY DELETED IN TUMORS, CANCER RESEARCH 53: 3382 (1993).
  16. SATO, T, ALLELOTYPE OF BREAST-CANCER - CUMULATIVE ALLELE LOSSES PROMOTE TUMOR PROGRESSION IN PRIMARY BREAST-CANCER, CANCER RESEARCH 50: 7184 (1990).
  17. SATO, T, ACCUMULATION OF GENETIC ALTERATIONS AND PROGRESSION OF PRIMARY BREAST-CANCER, CANCER RESEARCH 51: 5794 (1991).
  18. SMITH, S.A., ALLELE LOSSES IN THE REGION 17Q12-21 IN FAMILIAL BREAST AND OVARIAN-CANCER INVOLVE THE WILD-TYPE CHROMOSOME, NATURE GENETICS 2: 128 (1992). · DOI · Paper page

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Metadata

Authors
Futreal, P. A., Liu, Q., Shattuck-Eidens, D., Cochran, C., Harshman, K., Tavtigian, S., Bennett, L. M., Haugen-Strano, A., Swensen, J., Miki, Y., Eddington, K., McClure, M., Frye, C., Weaver-Feldhaus, J., Ding, W., Gholami, Z., Söderkvist, P., Terry, L., Jhanwar, S., Berchuck, A., Iglehart, J. D., Marks, J., Ballinger, D. G., Barrett, J. C., Skolnick, M. H., Kamb, A., & Wiseman, R.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1994-10-07
Volume
266
Issue
5182
Pages
120-122
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.7939630
OpenAlex
W2036546668
Cited by
1,205
References
1
FWCI
51.05
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: BRCA1 Mutations in Primary Breast and Ovarian Carcinomas. https://app.cochat.ai/papers/10.1126/science.7939630
The paper
Futreal, P. A., Liu, Q., Shattuck-Eidens, D., Cochran, C., Harshman, K., Tavtigian, S., Bennett, L. M., Haugen-Strano, A., Swensen, J., Miki, Y., Eddington, K., McClure, M., Frye, C., Weaver-Feldhaus, J., Ding, W., Gholami, Z., Söderkvist, P., Terry, L., Jhanwar, S., . . . Wiseman, R. (1994). BRCA1 Mutations in Primary Breast and Ovarian Carcinomas. Science. https://doi.org/10.1126/science.7939630

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.