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Cited by 1,205

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

BRCA1 Mutations in Primary Breast and Ovarian Carcinomas

Futreal, P. Andrew, Liu, Qingyun, Shattuck-Eidens, Donna, Cochran, Charles, Harshman, Keith, Tavtigian, Sean, Bennett, L. Michelle, Haugen-Strano, Astrid, Swensen, Jeff, Miki, Yoshio, Eddington, Ken, McClure, Melody, Frye, Cheryl, Weaver-Feldhaus, Jane, Ding, Wei, Gholami, Zahra, Söderkvist, Peter, Terry, Lori, Jhanwar, Suresh, Berchuck, Andrew, Iglehart, J. Dirk, Marks, Jeff, Ballinger, Dennis G., Barrett, J. Carl, Skolnick, Mark H., Kamb, Alexander, Wiseman, Roger·1994·Science
DOI 10.1126/science.7939630
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Abstract

Loss of heterozygosity data from familial tumors suggest that BRCA1 , a gene that confers susceptibility to ovarian and early-onset breast cancer, encodes a tumor suppressor. The BRCA1 region is also subject to allelic loss in sporadic breast and ovarian cancers, an indication that BRCA1 mutations may occur somatically in these tumors. The BRCA1 coding region was examined for mutations in primary breast and ovarian tumors that show allele loss at the BRCA1 locus. Mutations were detected in 3 of 32 breast and 1 of 12 ovarian carcinomas; all four mutations were germline alterations and occurred in early-onset cancers. These results suggest that mutation of BRCA1 may not be critical in the development of the majority of breast and ovarian cancers that arise in the absence of a mutant germline allele.

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Research works printed but not linked: 18

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  2. CROPP, C.S., EVIDENCE FOR INVOLVEMENT OF BRCA1 IN SPORADIC BREAST CARCINOMAS, CANCER RESEARCH 54: 2548 (1994).
  3. EASTON, D.F., GENETIC-LINKAGE ANALYSIS IN FAMILIAL BREAST AND OVARIAN-CANCER - RESULTS FROM 214 FAMILIES, AMERICAN JOURNAL OF HUMAN GENETICS 52: 678 (1993).
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  6. FUTREAL, P.A., ISOLATION OF A DIVERGED HOMEOBOX GENE, MOX1, FROM THE BRCA1 REGION ON 17Q21 BY SOLUTION HYBRID CAPTURE, HUMAN MOLECULAR GENETICS 3: 1359 (1994). · DOI
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  10. KELSELL, D.P., GENETIC-ANALYSIS OF THE BRCA1 REGION IN A LARGE BREAST OVARIAN FAMILY - REFINEMENT OF THE MINIMAL REGION CONTAINING BRCA1, HUMAN MOLECULAR GENETICS 2: 1823 (1993). · DOI
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Cited by

Metadata

Authors
Futreal, P. A., Liu, Q., Shattuck-Eidens, D., Cochran, C., Harshman, K., Tavtigian, S., Bennett, L. M., Haugen-Strano, A., Swensen, J., Miki, Y., Eddington, K., McClure, M., Frye, C., Weaver-Feldhaus, J., Ding, W., Gholami, Z., Söderkvist, P., Terry, L., Jhanwar, S., Berchuck, A., Iglehart, J. D., Marks, J., Ballinger, D. G., Barrett, J. C., Skolnick, M. H., Kamb, A., & Wiseman, R.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1994-10-07
Volume
266
Issue
5182
Pages
120-122
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.7939630
OpenAlex
W2036546668
Cited by
1,205
References
1
FWCI
51.05
Type
journal article
Language
en
Open access
closed

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