The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Quantitative Trait Locus for Reading Disability on Chromosome 6
Abstract
Interval mapping of data from two independent samples of sib pairs, at least one member of whom was reading disabled, revealed evidence for a quantitative trait locus (QTL) on chromosome 6. Results obtained from analyses of reading performance from 114 sib pairs genotyped for DNA markers localized the QTL to 6p21.3. Analyses of corresponding data from an independent sample of 50 dizygotic twin pairs provided evidence for linkage to the same region. In combination, the replicate samples yielded a χ 2 value of 16.73 (P =0.0002). Examination of twin and kindred siblings with more extreme deficits in reading performance yielded even stronger evidence for a QTL (χ 2 = 27.35, P < 0.00001). The position of the QTL was narrowly defined with a 100:1 confidence interval to a 2-centimorgan region within the human leukocyte antigen complex.
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Cites
Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.
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The investigation of linkage between a quantitative trait and a marker locus
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Left-handedness: association with immune disease, migraine, and developmental learning disorder.
Geschwind, N., & Behan, P. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.16.5097 · Cited by 1,165
Multiple regression analysis of twin data
DeFries, J. C., & Fulker, D. W. (1985) · Behavior Genetics · doi:10.1007/bf01066239 · Cited by 660
Self-citationSpecific Reading Disability: Identification of an Inherited Form Through Linkage Analysis
Smith, S. D., Kimberling, W. J., Pennington, B. F., & Lubs, H. A. (1983) · Science · doi:10.1126/science.6828864 · Cited by 328
Self-citationEvidence for a genetic aetiology in reading disability of twins
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Self-citationMultiple Regression Analysis of Twin Data: Etiology of Deviant Scores versus Individual Differences
DeFries, J. C., & Fulker, D. W. (1988) · Acta geneticae medicae et gemellologiae: twin research · doi:10.1017/s0001566000003810 · Cited by 297
Self-citationEvidence for Major Gene Transmission of Developmental Dyslexia
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Cited by
The Genetic Architecture of Quantitative Traits
Mackay, T. F. C. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.090633 · Cited by 1,106
LEVY, F., HAY, D. A., McSTEPHEN, M., WOOD, C., & WALDMAN, I. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199706000-00009 · Cited by 956
Vellutino, F. R., Scanlon, D. M., Sipay, E. R., & Small, S. G. (1996) · Journal of Educational Psychology · doi:10.1037//0022-0663.88.4.601 · Cited by 932
The magnocellular theory of developmental dyslexia
Stein, J. (2001) · Dyslexia · doi:10.1002/dys.186 · Cited by 872
Shaywitz, S. E. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380507 · Cited by 665
Metadata
- Authors
- Cardon, L. R., Smith, S. D., Fulker, D. W., Kimberling, W. J., Pennington, B. F., & DeFries, J. C.
- Venue
- Science
- Published
- 1994-10-14
- Volume
- 266
- Issue
- 5183
- Pages
- 276-279
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2100714054
- Cited by
- 532
- References
- 23
- FWCI
- 53.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cardon, L. R., Smith, S. D., Fulker, D. W., Kimberling, W. J., Pennington, B. F., & DeFries, J. C. (1994). Quantitative Trait Locus for Reading Disability on Chromosome 6. Science. https://doi.org/10.1126/science.7939663
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
