The DOI matches its Crossref record.
Restoration of X-ray Resistance and V(D)J Recombination in Mutant Cells by Ku cDNA
Abstract
Three genetic complementation groups of rodent cells are defective for both repair of x-ray-induced double-strand breaks and V(D)J recombination. Cells from one group lack a DNA end-binding activity that is biochemically and antigenically similar to the Ku autoantigen. Transfection of complementary DNA (cDNA) that encoded the 86-kilodalton subunit of Ku rescued these mutant cells for DNA end-binding activity, x-ray resistance, and V(D)J recombination activity. These results establish a role for Ku in DNA repair and recombination. Furthermore, as a component of a DNA-dependent protein kinase, Ku may initiate a signaling pathway induced by DNA damage.
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Cited by
Takata, M., Sasaki, M. S., Sonoda, E., Morrison, C., Hashimoto, M., Utsumi, H., Yamaguchi‐Iwai, Y., Shinohara, A., & Takeda, S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.18.5497 · Cited by 1,229
Taylor, H. S., Arici, A., Olive, D., & Igarashi, P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1057 · Cited by 484
Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV
Critchlow, S. E., Bowater, R. P., & Jackson, S. P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00258-2 · Cited by 470
Li, Z., Otevrel, T., Gao, Y., Cheng, H.-L., Seed, B., Stamato, T. D., Taccioli, G. E., & Alt, F. W. (1995) · Cell · doi:10.1016/0092-8674(95)90135-3 · Cited by 458
Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice
Gu, Y., Seidl, K. J., Rathbun, G. A., Zhu, C., Manis, J. P., van der Stoep, N., Davidson, L., Cheng, H.-L., Sekiguchi, J. M., Frank, K., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80386-6 · Cited by 451
Metadata
- Authors
- Smider, V., Rathmell, W. K., Lieber, M. R., & Chu, G.
- Venue
- Science
- Published
- 1994-10-14
- Volume
- 266
- Issue
- 5183
- Pages
- 288-291
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2005753349
- Cited by
- 348
- References
- 0
- FWCI
- 17.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Restoration of X-ray Resistance and V(D)J Recombination in Mutant Cells by Ku cDNA. https://app.cochat.ai/papers/10.1126/science.7939667
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- Smider, V., Rathmell, W. K., Lieber, M. R., & Chu, G. (1994). Restoration of X-ray Resistance and V(D)J Recombination in Mutant Cells by Ku cDNA. Science. https://doi.org/10.1126/science.7939667
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
