The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice
Open accessAbstract
Ku70, Ku80, and DNA-PKcs are subunits of the DNA-dependent protein kinase (DNA-PK), an enzyme implicated in DNA double-stranded break repair and V(D)J recombination. Our Ku70-deficient mice were about 50% the size of control littermates, and their fibroblasts were ionizing radiation sensitive and displayed premature senescence associated with the accumulation of nondividing cells. Ku70-deficient mice lacked mature B cells or serum immunoglobulin but, unexpectedly, reproducibly developed small populations of thymic and peripheral alpha/beta T lineage cells and had a significant incidence of thymic lymphomas. In association with B and T cell developmental defects, Ku70-deficient cells were severely impaired for joining of V(D)J coding and recombination signal sequences. These unanticipated features of the Ku70-deficient phenotype with respect to lymphocyte development and V(D)J recombination may reflect differential functions of the three DNA-PK components.
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Cited by
Genomic Instability in Mice Lacking Histone H2AX
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DNA Repair, Genome Stability, and Aging
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Self-citationXLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining
Ahnesorg, P., Smith, P., & Jackson, S. P. (2006) · Cell · doi:10.1016/j.cell.2005.12.031 · Cited by 794
Metadata
- Authors
- Gu, Y., Seidl, K. J., Rathbun, G. A., Zhu, C., Manis, J. P., van der Stoep, N., Davidson, L., Cheng, H.-L., Sekiguchi, J. M., Frank, K., Stanhope-Baker, P., Schlissel, M. S., Roth, D. B., & Alt, F. W.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1997-11
- Volume
- 7
- Issue
- 5
- Pages
- 653-665
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1988845313
- Cited by
- 451
- References
- 70
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gu, Y., Seidl, K. J., Rathbun, G. A., Zhu, C., Manis, J. P., van der Stoep, N., Davidson, L., Cheng, H.-L., Sekiguchi, J. M., Frank, K., Stanhope-Baker, P., Schlissel, M. S., Roth, D. B., & Alt, F. W. (1997). Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice. Immunity. https://doi.org/10.1016/s1074-7613(00)80386-6
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