The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Folding of VSV G Protein: Sequential Interaction with BiP and Calnexin
Abstract
The endoplasmic reticulum (ER) contains molecular chaperones that facilitate the folding of proteins in mammalian cells. Biosynthetic labeling was used to study the interactions of two chaperones, BiP and calnexin, with vesicular stomatitis virus (VSV) glycoprotein (G protein). Coimmunoprecipitation of G protein with the chaperones showed that BiP bound maximally to early folding intermediates of G protein, whereas calnexin bound after a short lag to more folded molecules. Castanospermine, an inhibitor of ER glucosidases, blocked the binding of proteins to calnexin and inhibited G protein folding. Interaction with calnexin was necessary for efficient folding of G protein and for retention of partially folded forms.
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Citations
Cites
Hammond, C., Braakman, I., & Helenius, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.3.913 · Cited by 841
Self-citationHammond, C., & Helenius, A. (1994) · The Journal of cell biology · doi:10.1083/jcb.126.1.41 · Cited by 443
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Cited by
Roles of N-Linked Glycans in the Endoplasmic Reticulum
Helenius, A., & Aebi, M. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073752 · Cited by 2,037
Self-citationOne step at a time: endoplasmic reticulum-associated degradation
Vembar, S. S., & Brodsky, J. L. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2546 · Cited by 1,299
BI-DIRECTIONAL PROTEIN TRANSPORT BETWEEN THE ER AND GOLGI
Lee, M. C. S., Miller, E. A., Goldberg, J., Orci, L., & Schekman, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.105307 · Cited by 813
Role and regulation of the ER chaperone BiP
Gething, M.-J. (1999) · Seminars in Cell & Developmental Biology · doi:10.1006/scdb.1999.0318 · Cited by 555
Hebert, D. N., Foellmer, B., & Helenius, A. (1995) · Cell · doi:10.1016/0092-8674(95)90395-x · Cited by 552
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Metadata
- Authors
- Hammond, C., & Helenius, A.
- Venue
- Science
- Published
- 1994-10-21
- Volume
- 266
- Issue
- 5184
- Pages
- 456-458
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2034264764
- Cited by
- 319
- References
- 2
- FWCI
- 11.92
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
