The DOI matches its Crossref record.
Transformation of Lupus-Inducing Drugs to Cytotoxic Products by Activated Neutrophils
Abstract
Drug-induced lupus is a serious side effect of certain medications, but the chemical features that confer this property and the underlying pathogenesis are puzzling. Prototypes of all six therapeutic classes of lupus-inducing drugs were highly cytotoxic only in the presence of activated neutrophils. Removal of extracellular hydrogen peroxide before, but not after, exposure of the drug to activated neutrophils prevented cytotoxicity. Neutrophil-dependent cytotoxicity required the enzymatic action of myeloperoxidase, resulting in the chemical transformation of the drug to a reactive product. The capacity of drugs to serve as myeloperoxidase substrates in vitro was associated with the ability to induce lupus in vivo.
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Citations
Cited by
Pharmacogenetics, Drug-Metabolizing Enzymes, and Clinical Practice
Gardiner, S. J., & Begg, E. J. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.6 · Cited by 406
Renal toxicity of therapeutic drugs
John, R., & Herzenberg, A. M. (2009) · Journal of Clinical Pathology · doi:10.1136/jcp.2008.058271 · Cited by 93
Yazisiz, V., ÃNgüt, G., TerzioÄlu, E., & Karayalçin, Ã. (2010) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2007.01485.x · Cited by 31
Metadata
- Authors
- Jiang, X., Khursigara, G., & Rubin, R. L.
- Venue
- Science
- Published
- 1994-11-04
- Volume
- 266
- Issue
- 5186
- Pages
- 810-813
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2003520876
- Cited by
- 235
- References
- 0
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Transformation of Lupus-Inducing Drugs to Cytotoxic Products by Activated Neutrophils. https://app.cochat.ai/papers/10.1126/science.7973636
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- Jiang, X., Khursigara, G., & Rubin, R. L. (1994). Transformation of Lupus-Inducing Drugs to Cytotoxic Products by Activated Neutrophils. Science. https://doi.org/10.1126/science.7973636
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
