Renal toxicity of therapeutic drugs
Abstract
A number of therapeutic agents can adversely affect the kidney, resulting in tubulointerstitial, glomerular or vascular disease. Drug-induced tubulointerstitial nephritis and acute tubular necrosis are common, and are often cause by antibiotics or non-steroidal anti-inflammatory drugs. Drug-induced glomerular and vascular disease is relatively rare. This review describes the morphological patterns of drug-induced disease in the kidney. The histopathological changes are often similar to disease that is idiopathic or due to other causes, so that awareness and clinical correlation are most helpful to arrive at the aetiology.
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The presence of a large number of neutrophils, particularly as micro-abscesses, should alert one to the possibility of pyelonephritis.
“The presence of a large number of neutrophils [1], particularly as micro-abscesses, should alert one to the possibility of pyelonephritis [68].”
From The diagnosis of acute interstitial nephritis caused by infection versus antibiotic-induced interstitial nephritis: a narrative review (2024) · cites this paper as [68]
Cites
González, E., Gutiérrez, E., Galeano, C., Chevia, C., de Sequera, P., Bernis, C., Parra, E. G., Delgado, R., Sanz, M., Ortiz, M., et al. (2008) · Kidney International · doi:10.1038/sj.ki.5002776 · Cited by 466 · see citing works
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Muhammad, A., Zhang, Y., Huang, L., Yuan, Q., Wang, W., Pu, J., Lin, W., Tang, R., & Xiao, X. (2024) · Clinical Kidney Journal · doi:10.1093/ckj/sfae054 · Cited by 13 · see citing works
“The presence of a large number of neutrophils [1 ], particularly as micro-abscesses, should alert one to the possibility of pyelonephritis [68 ].”
Background
- Authors
- John, R., & Herzenberg, A. M.
- Affiliations
- University Health Network (CA)
- Corresponding author
- Herzenberg, A M
- ORCID
- John, R
- Venue
- Journal of Clinical Pathology
- Publisher
- BMJ
- Published
- 2009-05-27
- Volume
- 62
- Issue
- 6
- Pages
- 505-515
- ISSN
- 0021-9746 (ISSN-L)
- 1472-4146
- OpenAlex
- W1966525272
- Cited by
- 93
- References
- 1
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 8 · 2019: 4 · 2018: 7 · 2017: 3 · 2016: 4 · 2015: 9 · 2014: 5 · 2013: 2 · 2012: 10
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Pathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Nephrotoxicity and Medicinal Plants
- Keywords
- drug-induced nephrotoxicity, nephrotoxicity, acute tubular necrosis, drug-induced glomerulonephritis, nonsteroidal anti-inflammatory drugs, antibiotics, kidney histopathology, differential diagnosis
- MeSH terms
- Glomerulonephritis, Glomerulosclerosis, Focal Segmental, Humans, Kidney, Kidney Diseases, Kidney Failure, Chronic, Kidney Glomerulus, Kidney Tubules, Nephritis, Interstitial, Vasculitis, Drug-Related Side Effects and Adverse Reactions
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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