The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Toxic Shock Syndrome Toxin-1 Complexed with a Class II Major Histocompatibility Molecule HLA-DR1
Abstract
The three-dimensional structure of a Staphylococcus aureus superantigen, toxic shock syndrome toxin-1 (TSST-1), complexed with a human class II major histocompatibility molecule (DR1), was determined by x-ray crystallography. The TSST-1 binding site on DR1 overlaps that of the superantigen S. aureus enterotoxin B (SEB), but the two binding modes differ. Whereas SEB binds primarily off one edge of the peptide binding site of DR1, TSST-1 extends over almost one-half of the binding site and contacts both the flanking α helices of the histocompatibility antigen and the bound peptide. This difference suggests that the T cell receptor (TCR) would bind to TSST-1:DR1 very differently than to DR1:peptide or SEB:DR1. It also suggests that TSST-1 binding may be dependent on the peptide, though less so than TCR binding, providing a possible explanation for the inability of TSST-1 to competitively block SEB binding to all DR1 molecules on cells (even though the binding sites of TSST-1 and SEB on DR1 overlap almost completely) and suggesting the possibility that T cell activation by superantigen could be directed by peptide antigen.
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Cites
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The interpretation of protein structures: Estimation of static accessibility
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Structure of the human class I histocompatibility antigen, HLA-A2
Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L., & Wiley, D. C. (1987) · Nature · doi:10.1038/329506a0 · Cited by 3,472
Self-citationThree-dimensional structure of the human class II histocompatibility antigen HLA-DR1
Brown, J. H., Jardetzky, T. S., Gorga, J. C., Stern, L. J., Urban, R. G., Strominger, J. L., & Wiley, D. C. (1993) · Nature · doi:10.1038/364033a0 · Cited by 2,379
Self-citationThe Staphylococcal Enterotoxins and Their Relatives
Marrack, P., & Kappler, J. (1990) · Science · doi:10.1126/science.2185544 · Cited by 1,895
Stern, L. J., Brown, J. H., Jardetzky, T. S., Gorga, J. C., Urban, R. G., Strominger, J. L., & Wiley, D. C. (1994) · Nature · doi:10.1038/368215a0 · Cited by 1,555
Self-citationEvaluation of single-crystal X-ray diffraction data from a position-sensitive detector
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Self-citationRefined structure of the human histocompatibility antigen HLA-A2 at 2.6 Å resolution
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Cited by
Toxic Shock Syndrome and Bacterial Superantigens: An Update
McCormick, J. K., Yarwood, J. M., & Schlievert, P. M. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.77 · Cited by 785
Staphylococcus aureus Secreted Toxins and Extracellular Enzymes
Tam, K., & Torres, V. J. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0039-2018 · Cited by 452
Zinc-Altered Immune Function and Cytokine Production
Rink, L., & Kirchner, H. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.5.1407s · Cited by 271
Chavakis, T., Hussain, M., Kanse, S. M., Peters, G., Bretzel, R. G., Flock, J.-I., Herrmann, M., & Preissner, K. T. (2002) · Nature Medicine · doi:10.1038/nm728 · Cited by 264
Pless, D. D., Ruthel, G., Reinke, E. K., Ulrich, R. G., & Bavari, S. (2005) · Infection and Immunity · doi:10.1128/iai.73.9.5358-5366.2005 · Cited by 25
Metadata
- Authors
- Kim, J., Urban, R. G., Strominger, J. L., & Wiley, D. C.
- Venue
- Science
- Published
- 1994-12-16
- Volume
- 266
- Issue
- 5192
- Pages
- 1870-1874
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1995134733
- Cited by
- 302
- References
- 29
- FWCI
- 10.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kim, J., Urban, R. G., Strominger, J. L., & Wiley, D. C. (1994). Toxic Shock Syndrome Toxin-1 Complexed with a Class II Major Histocompatibility Molecule HLA-DR1. Science. https://doi.org/10.1126/science.7997880
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
