The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Maternal Rescue of Transforming Growth Factor-β 1 Null Mice
Abstract
Maternal sources of transforming growth factor-β1 (TGF-β1) are shown here to contribute to the normal appearance and perinatal survival of TGF-β1 null newborn mice. Labeled TGF-β1 crossed the placenta and was recovered intact from various tissues after oral administration to mouse pups. TGFβ-1 protein was also detected in cells recovered from breast milk. In immunohistochemical analyses, TGF-β1 null embryos and null newborn pups born to TGF-β1 heterozygotes stained positive for TGF-β1, whereas those born to a null female were negative and had severe cardiac abnormalities. These results suggest an important role for maternal sources of TGF-β1 during development and, more generally, provide evidence for maternal rescue of targeted gene disruption in the fetus.
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Citations
Cites
Kulkarni, A. B., Huh, C. G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. B., Sporn, M. B., Ward, J. M., & Karlsson, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.770 · Cited by 1,967
Self-citationGeiser, A. G., Letterio, J. J., Kulkarni, A. B., Karlsson, S., Roberts, A. B., & Sporn, M. B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.9944 · Cited by 179
Self-citation
Cited by
Regulation of Wound Healing by Growth Factors and Cytokines
WERNER, S., & GROSE, R. (2003) · Physiological Reviews · doi:10.1152/physrev.2003.83.3.835 · Cited by 3,629
Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice
Dickson, M. C., Martin, J. S., Cousins, F. M., Kulkarni, A. B., Karlsson, S., & Akhurst, R. J. (1995) · Development · doi:10.1242/dev.121.6.1845 · Cited by 1,029
Self-citationLuo, G., Hofmann, C., Bronckers, A. L., Sohocki, M., Bradley, A., & Karsenty, G. (1995) · Genes & Development · doi:10.1101/gad.9.22.2808 · Cited by 1,021
Maternal Effects in Animal Ecology
BERNARDO, J. (1996) · American Zoologist · doi:10.1093/icb/36.2.83 · Cited by 871
Brutsaert, D. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00017.2002 · Cited by 697
Metadata
- Authors
- Letterio, J. J., Geiser, A. G., Kulkarni, A. B., Roche, N. S., Sporn, M. B., & Roberts, A. B.
- Venue
- Science
- Published
- 1994-06-24
- Volume
- 264
- Issue
- 5167
- Pages
- 1936-1938
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1976275689
- Cited by
- 495
- References
- 2
- FWCI
- 10.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Maternal Rescue of Transforming Growth Factor-β 1 Null Mice. https://app.cochat.ai/papers/10.1126/science.8009224
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- Letterio, J. J., Geiser, A. G., Kulkarni, A. B., Roche, N. S., Sporn, M. B., & Roberts, A. B. (1994). Maternal Rescue of Transforming Growth Factor-β 1 Null Mice. Science. https://doi.org/10.1126/science.8009224
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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