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Receptor and Ligand Domains for Invasion of Erythrocytes by Plasmodium falciparum
Abstract
A 175-kilodalton erythrocyte binding protein, EBA-175, of the parasite Plasmodium falciparum mediates the invasion of erythrocytes. The erythrocyte receptor for EBA-175 is dependent on sialic acid. The domain of EBA-175 that binds erythrocytes was identified as region II with the use of truncated portions of EBA-175 expressed on COS cells. Region II, which contains a cysteine-rich motif, and native EBA-175 bind specifically to glycophorin A, but not to glycophorin B, on the erythrocyte membrane. Erythrocyte recognition of EBA-175 requires both sialic acid and the peptide backbone of glycophorin A. The identification of both the receptor and ligand domains may suggest rational designs for receptor blockade and vaccines.
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Citations
Cited by
Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635
“With regard to parasites, a well-known example is the merozoite stage of Plasmodium falciparum, which initiates malaria via recognition of densely sialylated glycophorins on target erythrocytes (723) (724) (725) (726) (727) (728) (729) (730) , with the types of sialic acids presented affecting species specificity (731…”
BackgroundSu, X.-Z., Heatwole, V. M., Wertheimer, S. P., Guinet, F., Herrfeldt, J. A., Peterson, D. S., Ravetch, J. A., & Wellems, T. E. (1995) · Cell · doi:10.1016/0092-8674(95)90055-1 · Cited by 1,219
Smith, J. D., Chitnis, C. E., Craig, A. G., Roberts, D. J., Hudson-Taylor, D. E., Peterson, D. S., Pinches, R., Newbold, C. I., & Miller, L. H. (1995) · Cell · doi:10.1016/0092-8674(95)90056-x · Cited by 1,005
Self-citationEvolutionary considerations in relating oligosaccharide diversity to biological function
Gagneux, P., & Varki, A. (1999) · Glycobiology · doi:10.1093/glycob/9.8.747 · Cited by 495
Reeder, J. C., Cowman, A. F., Davern, K. M., Beeson, J. G., Thompson, J. K., Rogerson, S. J., & Brown, G. V. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5198 · Cited by 252
Metadata
- Authors
- Sim, B. K. L., Chitnis, C. E., Wasniowska, K., Hadley, T. J., & Miller, L. H.
- Venue
- Science
- Published
- 1994-06-24
- Volume
- 264
- Issue
- 5167
- Pages
- 1941-1944
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2083126580
- Cited by
- 545
- References
- 0
- FWCI
- 25.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Receptor and Ligand Domains for Invasion of Erythrocytes by Plasmodium falciparum. https://app.cochat.ai/papers/10.1126/science.8009226
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- Sim, B. K. L., Chitnis, C. E., Wasniowska, K., Hadley, T. J., & Miller, L. H. (1994). Receptor and Ligand Domains for Invasion of Erythrocytes by Plasmodium falciparum. Science. https://doi.org/10.1126/science.8009226
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
