The adhesion of Plasmodium falciparum -infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1
Open accessAbstract
Chondroitin sulfate A (CSA) is an important receptor for the sequestration of Plasmodium falciparum in the placenta, but the parasite ligand involved in adhesion has not previously been identified. Here we report the identification of a var gene transcribed in association with binding to CSA and present evidence that the P. falciparum erythrocyte membrane protein 1 product of the gene is the parasite ligand mediating CSA binding. Description of this gene and the implication of P. falciparum erythrocyte membrane protein 1 as the parasite ligand paves the way to a more detailed understanding of the pathogenesis of placental infection and potential therapeutic strategies targeting the interaction.
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Several groups have identified CSA-binding domains in PfEMP1 molecules.
“Several groups have identified CSA-binding domains in PfEMP1 molecules (19-21).”
From Evidence for the Involvement of VAR2CSA in Pregnancy-associated Malaria (2004) · cites this paper as [20]
The Results report that antibodies against PfEMP1’s DBL3 and CIDR regions inhibited adhesion to CSA. But the Discussion explicitly says this does not conclusively locate the binding site and leaves its definition to future work. This paper therefore implicates domains without establishing them as CSA-binding domains. (LLM, conf=0.88)
Experimental — accuracy not yet measuredLow parasite densities are expected because the majority of parturients were multigravidae and antibodies against specific placental tissue-adhering P. falciparum strains are gradually acquired with successive pregnancies.
“are expected since majority of the parturients were multigravidae and antibodies against specific placental tissue-adhering P. falciparum strains [44, 45] are thought to be gradually acquired with successive pregnancies [46].”
From Intermittent preventive treatment with Sulphadoxine-Pyrimethamine (IPTp-SP) is associated with protection against sub-microscopic P. falciparum infection in pregnant women during the low transmission dry season in southwestern Cameroon: A Semi - longitudinal study (2022) · cites this paper as [44]
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- Authors
- Reeder, J. C., Cowman, A. F., Davern, K. M., Beeson, J. G., Thompson, J. K., Rogerson, S. J., & Brown, G. V.
- Affiliations
- The Royal Melbourne Hospital (AU)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1999-04-27
- Volume
- 96
- Issue
- 9
- Pages
- 5198-5202
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC21841
- OpenAlex
- W2093451052
- Cited by
- 252
- References
- 39
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 8 · 2013: 1 · 2012: 7
- FWCI
- 38.10
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Keywords
- Plasmodium falciparum, chondroitin sulfate A, erythrocyte adhesion, erythrocyte membrane protein 1, var genes, placental malaria, sequestration
- MeSH terms
- Animals, Cell Adhesion, Chondroitin Sulfates, Erythrocyte Membrane, Erythrocytes, Female, Cricetinae, Humans, Ligands, Molecular Sequence Data, Placenta, Plasmodium falciparum, Pregnancy, Protozoan Proteins, CHO Cells, Malaria, Falciparum
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