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Identification of the Target of a Transcription Activator Protein by Protein-Protein Photocrosslinking
Abstract
Here it is shown, with the use of protein-protein photocrosslinking, that the carboxyl-terminal region of the α subunit of RNA polymerase (RNAP) is in direct physical proximity to the activating region of the catabolite gene activator protein (CAP) in the ternary complex of the lac promoter, RNAP, and CAP. These results strongly support the proposal that transcription activation by CAP involves protein-protein contact between the carboxyl-terminal region of the α subunit and the activating region of CAP.
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Citations
Cited by
Transcriptional activation by recruitment
Ptashne, M., & Gann, A. (1997) · Nature · doi:10.1038/386569a0 · Cited by 1,158
Addition of p-Azido-l-phenylalanine to the Genetic Code of Escherichia coli
Chin, J. W., Santoro, S. W., Martin, A. B., King, D. S., Wang, L., & Schultz, P. G. (2002) · Journal of the American Chemical Society · doi:10.1021/ja027007w · Cited by 721
Metadata
- Authors
- Chen, Y., Ebright, Y. W., & Ebright, R. H.
- Venue
- Science
- Published
- 1994-07
- Volume
- 265
- Issue
- 5168
- Pages
- 90-92
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2026348560
- Cited by
- 167
- References
- 0
- FWCI
- 11.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Identification of the Target of a Transcription Activator Protein by Protein-Protein Photocrosslinking. https://app.cochat.ai/papers/10.1126/science.8016656
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- Chen, Y., Ebright, Y. W., & Ebright, R. H. (1994). Identification of the Target of a Transcription Activator Protein by Protein-Protein Photocrosslinking. Science. https://doi.org/10.1126/science.8016656
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
