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The High-Resolution Crystal Structure of a Parallel-Stranded Guanine Tetraplex
Abstract
Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG 4 T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts.
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Citations
Cites
Structure and function of telomeres
Blackburn, E. H. (1991) · Nature · doi:10.1038/350569a0 · Cited by 3,596
Cited by
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Sun, D., Thompson, B., Cathers, B. E., Salazar, M., Kerwin, S. M., Trent, J. O., Jenkins, T. C., Neidle, S., & Hurley, L. H. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm970199z · Cited by 794
Loop-Length-Dependent Folding of G-Quadruplexes
Hazel, P., Huppert, J., Balasubramanian, S., & Neidle, S. (2004) · Journal of the American Chemical Society · doi:10.1021/ja045154j · Cited by 494
The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif
Schaeffer, C., Bardoni, B., Mandel, J., Ehresmann, B., Ehresmann, C., & Moine, H. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4803 · Cited by 471
A ribozyme and a catalytic DNA with peroxidase activity: active sites versus cofactor-binding sites
Travascio, P., Bennet, A. J., Wang, D. Y., & Sen, D. (1999) · Chemistry & Biology · doi:10.1016/s1074-5521(99)80125-2 · Cited by 391
Targeted tumor therapy with the TGF-β2 antisense compound AP 12009
SCHLINGENSIEPEN, K., SCHLINGENSIEPEN, R., STEINBRECHER, A., HAU, P., BOGDAHN, U., FISCHERBLASS, B., & JACHIMCZAK, P. (2006) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.09.002 · Cited by 195
Metadata
- Authors
- Laughlan, G., Murchie, A. I. H., Norman, D. G., Moore, M. H., Moody, P. C. E., Lilley, D. M. J., & Luisi, B.
- Venue
- Science
- Published
- 1994-07-22
- Volume
- 265
- Issue
- 5171
- Pages
- 520-524
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2011844193
- Cited by
- 482
- References
- 1
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Laughlan, G., Murchie, A. I. H., Norman, D. G., Moore, M. H., Moody, P. C. E., Lilley, D. M. J., & Luisi, B. (1994). The High-Resolution Crystal Structure of a Parallel-Stranded Guanine Tetraplex. Science. https://doi.org/10.1126/science.8036494
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