The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Interaction of Rac with p67 phox and Regulation pf Phagocytic NADPH Oxidase Activity
Abstract
Rho and Rac, two members of the Ras superfamily of guanosine triphosphate (GTP)-binding proteins, regulate a variety of signal transduction pathways in eukaryotic cells. Upon stimulation of phagocytic cells, Rac enhances the activity of the enzyme nicotinamide adenine dinucleotide phosphate (reduced) (NADPH) oxidase, resulting in the production of superoxide radicals. Activation of the NADPH oxidase requires the assembly of a multimolecular complex at the plasma membrane consisting of two integral membrane proteins, gp91 phox and p21 phox , and two cytosolic proteins, p67 phox and p47 phox . Rac1 interacted directly with p67 phox in a GTP-dependent manner. Modified forms of Rac with mutations in the effector site did not stimulate oxidase activity or bind to p67 phox . Thus, p67 phox appears to be the Rac effector protein in the NADPH oxidase complex.
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Cites
Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 c-src
Leto, T. L., Lomax, K. J., Volpp, B. D., Nunoi, H., Sechler, J. M. G., Nauseef, W. M., Clark, R. A., Gallin, J. I., & Malech, H. L. (1990) · Science · doi:10.1126/science.1692159 · Cited by 386
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RHO GTPASES: Biochemistry and Biology
Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009
Self-citationRho GTPases and their effector proteins
BISHOP, A. L., & HALL, A. (2000) · Biochemical Journal · doi:10.1042/bj3480241 · Cited by 2,575
Self-citationMitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts
Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., & Goldschmidt-Clermont, P. J. (1997) · Science · doi:10.1126/science.275.5306.1649 · Cited by 1,588
Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions
Qin, C., Yang, S., Chu, Y.-H., Zhang, H., Pang, X.-W., Chen, L., Zhou, L.-Q., Chen, M., Tian, D.-S., & Wang, W. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01064-1 · Cited by 939
Sumimoto, H. (2008) · The FEBS Journal · doi:10.1111/j.1742-4658.2008.06488.x · Cited by 721
Metadata
- Authors
- Diekmann, D., Abo, A., Johnston, C., Segal, A. W., & Hall, A.
- Venue
- Science
- Published
- 1994-07-22
- Volume
- 265
- Issue
- 5171
- Pages
- 531-533
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2024891861
- Cited by
- 382
- References
- 1
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Diekmann, D., Abo, A., Johnston, C., Segal, A. W., & Hall, A. (1994). Interaction of Rac with p67 phox and Regulation pf Phagocytic NADPH Oxidase Activity. Science. https://doi.org/10.1126/science.8036496
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