The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Integration and Germ-Line Transmission of a Pseudotyped Retroviral Vector in Zebrafish
Abstract
The zebrafish is rapidly becoming a popular model system for the study of vertebrate development because it is ideal for both embryological studies and genetic analysis. To determine if a retroviral vector pseudotyped with the envelope glycoprotein of the vesicular stomatitis virus could infect zebrafish embryos, and in particular, the cells destined to become the germ line, a pseudotyped virus was injected into blastula-stage zebrafish embryos. Fifty-one embryos were allowed to develop and eight transmitted proviral DNA to their progeny. Founders were mosaic, but as expected, transgenic F 1 's transmitted proviral DNA in a Mendelian fashion to the F 2 progeny. Transgenic F 1 fish inherited a single integrated provirus, and a single founder could transmit more than one viral integration to its progeny. These results demonstrate that this pantropic pseudotyped vector, originally developed for human gene therapy, will make the use of retroviral vectors in zebrafish possible.
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Citations
Cites
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Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate
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Form and Function of Retroviral Proviruses
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Cited by
Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity
Hill, A. J., Teraoka, H., Heideman, W., & Peterson, R. E. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi110 · Cited by 1,374
A Transposon-Mediated Gene Trap Approach Identifies Developmentally Regulated Genes in Zebrafish
Kawakami, K., Takeda, H., Kawakami, N., Kobayashi, M., Matsuda, N., & Mishina, M. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.06.005 · Cited by 849
Tol2: a versatile gene transfer vector in vertebrates
Kawakami, K. (2007) · Genome Biology · doi:10.1186/gb-2007-8-s1-s7 · Cited by 566
Kawakami, K., Shima, A., & Kawakami, N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11403 · Cited by 477
Higashijima, S.-I., Okamoto, H., Ueno, N., Hotta, Y., & Eguchi, G. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8779 · Cited by 417
Metadata
- Authors
- Lin, S., Gaiano, N., Culp, P., Burns, J. C., Friedmann, T., Yee, J.-K., & Hopkins, N.
- Venue
- Science
- Published
- 1994-07-29
- Volume
- 265
- Issue
- 5172
- Pages
- 666-669
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1968883761
- Cited by
- 278
- References
- 17
- FWCI
- 10.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lin, S., Gaiano, N., Culp, P., Burns, J. C., Friedmann, T., Yee, J.-K., & Hopkins, N. (1994). Integration and Germ-Line Transmission of a Pseudotyped Retroviral Vector in Zebrafish. Science. https://doi.org/10.1126/science.8036514
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
