The DOI matches its Crossref record.
Fetal Hemoglobin Restriction to a Few Erythrocytes (F Cells) in Normal Human Adults
Abstract
During adult life, the quantity of fetal hemoglobin (HbF) present in F cells—that is, rare erythrocytes which are reactive with rabbit antiserum to human HbF during microscopic immunodiffusion—is sufficient to account for all of the small quantity (less than 0.7 percent) of HbF normally present in whole blood. Thus, erythrocytes are normally heterogeneous with respect to the presence of HbF.
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Citations
Cited by
Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias
Weatherall, D. J. (2001) · Nature Reviews Genetics · doi:10.1038/35066048 · Cited by 692
Reactivation of developmentally silenced globin genes by forced chromatin looping
Deng, W., Rupon, J. W., Krivega, I., Breda, L., Motta, I., Jahn, K. S., Reik, A., Gregory, P. D., Rivella, S., Dean, A., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.050 · Cited by 443
“Cellular Distribution of g-Globin Protein in Adult Erythroid Cells Containing GG1-SA Fetal hemoglobin (HbF) production is heterocellular in normal individuals in whom a small proportion of cells with high level of HbF accounts for the overall low HbF levels (Boyer et al., 1975; Wood et al., 1975).”
BackgroundControl of globin gene expression during development and erythroid differentiation
Stamatoyannopoulos, G. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2004.11.007 · Cited by 393
Genetic influences on F cells and other hematologic variables: a twin heritability study
Garner, C., Tatu, T., Reittie, J. E., Littlewood, T., Darley, J., Cervino, S., Farrall, M., Kelly, P., Spector, T. D., & Thein, S. L. (2000) · Blood · doi:10.1182/blood.v95.1.342 · Cited by 274
Fetal hemoglobin in sickle cell anemia: a glass half full?
Steinberg, M. H., Chui, D. H. K., Dover, G. J., Sebastiani, P., & Alsultan, A. (2014) · Blood · doi:10.1182/blood-2013-09-528067 · Cited by 267
Metadata
- Authors
- Boyer, S. H., Belding, T. K., Margolet, L., & Noyes, A. N.
- Venue
- Science
- Published
- 1975-04-25
- Volume
- 188
- Issue
- 4186
- Pages
- 361-363
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077813077
- Cited by
- 239
- References
- 0
- FWCI
- 9.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Fetal Hemoglobin Restriction to a Few Erythrocytes (F Cells) in Normal Human Adults. https://app.cochat.ai/papers/10.1126/science.804182
- The paper
- Boyer, S. H., Belding, T. K., Margolet, L., & Noyes, A. N. (1975). Fetal Hemoglobin Restriction to a Few Erythrocytes (F Cells) in Normal Human Adults. Science. https://doi.org/10.1126/science.804182
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
