Control of globin gene expression during development and erythroid differentiation

Position-independent, high-level expression of the human β-globin gene in transgenic mice

Grosveld, F. G., van Assendelft, G. B., Greaves, D. R., & Kollias, G. A. (1987) · Cell · doi:10.1016/0092-8674(87)90584-8 · Cited by 1,908 · see citing works

Looping and Interaction between Hypersensitive Sites in the Active β-globin Locus

Tolhuis, B., Palstra, R.-J., Splinter, E., Grosveld, F., & de Laat, W. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00781-5 · Cited by 1,344 · see citing works

Active genes dynamically colocalize to shared sites of ongoing transcription

Osborne, C. S., Chakalova, L., Brown, K. E., Carter, D., Horton, A., Debrand, E., Goyenechea, B., Mitchell, J. A., Lopes, S. M. C. D. S., Reik, W., et al. (2004) · Nature Genetics · doi:10.1038/ng1423 · Cited by 1,046 · see citing works

Going the Distance: A Current View of Enhancer Action

Blackwood, E. M., & Kadonaga, J. T. (1998) · Science · doi:10.1126/science.281.5373.60 · Cited by 836 · see citing works

Mammalian Membrane-bound Adenylyl Cyclases

Taussig, R., & Gilman, A. G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.1.1 · Cited by 719 · see citing works

A Novel, Erythroid Cell-Specific Murine Transcription Factor that Binds to the CACCC Element and is Related to the Krüppel Family of Nuclear Proteins†

Miller, I. J., & Bieker, J. J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.5.2776-2786.1993 · Cited by 719 · see citing works

The Molecular Basis of Blood Diseases.

(1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-6-950_3 · Cited by 640 · see citing works

The "beta-like-globin" gene domain in human erythroid cells.

Tuan, D., Solomon, W., Li, Q., & London, I. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.19.6384 · Cited by 601 · see citing works

Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia.

Platt, O., Orkin, S. H., Dover, G., Beardsley, G. P., Miller, B. A., & Nathan, D. G. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111464 · Cited by 532 · see citing works

5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β⁺Thalassemia

Ley, T. J., DeSimone, J., Anagnou, N. P., Keller, G. H., Humphries, R. K., Turner, P. H., Young, N. S., Heller, P., & Nienhuis, A. W. (1982) · New England Journal of Medicine · doi:10.1056/nejm198212093072401 · Cited by 490 · see citing works

Looping versus linking: toward a model for long-distance gene activationPreprint

Bulger, M., & Groudine, M. T. (1999) · Genes & Development · doi:10.1101/gad.13.19.2465 · Cited by 483 · see citing works

Transcription complex stability and chromatin dynamics in vivo

Wijgerde, M., Grosveld, F. G., & Fraser, P. (1995) · Nature · doi:10.1038/377209a0 · Cited by 471 · see citing works

A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.Preprint

Forrester, W. C., Epner, E. M., Driscoll, M. C., Enver, T., Brice, M. C., Papayannopoulou, T., & Groudine, M. T. (1990) · Genes & Development · doi:10.1101/gad.4.10.1637 · Cited by 464 · see citing works

Locus control regions

Li, Q., Peterson, K. R., Fang, X., & Stamatoyannopoulos, G. (2002) · Blood · doi:10.1182/blood-2002-04-1104 · Cited by 456 · see citing works

Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids

Forrester, W. C., Takegawa, S., Papayannopoulou, T., Stamatoyannopoulos, G., & Groudine, M. T. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.24.10159 · Cited by 418 · see citing works

5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons.

DeSimone, J., Heller, P., Hall, L., & Zwiers, D. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.14.4428 · Cited by 384 · see citing works

Insulators and Boundaries: Versatile Regulatory Elements in the Eukaryotic Genome

Bell, A. C., West, A. G., & Felsenfeld, G. (2001) · Science · doi:10.1126/science.291.5503.447 · Cited by 381 · see citing works

A developmentally stable chromatin structure in the human beta-globin gene cluster.

Forrester, W. C., Thompson, C. B., Elder, J. T., & Groudine, M. T. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.5.1359 · Cited by 376 · see citing works

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice

Enver, T., Raich, N., Ebens, A. J., Papayannopoulou, T., Costantini, F. D., & Stamatoyannopoulos, G. (1990) · Nature · doi:10.1038/344309a0 · Cited by 345 · see citing works

Human gamma- to beta-globin gene switching in transgenic mice.Preprint

Behringer, R. R., Ryan, T. M., Palmiter, R. D., Brinster, R. L., & Townes, T. M. (1990) · Genes & Development · doi:10.1101/gad.4.3.380 · Cited by 278 · see citing works

Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex.

Charache, S., Dover, G., Smith, K. D., Talbot, C. C., Moyer, M. A., & Boyer, S. H. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.15.4842 · Cited by 270 · see citing works

F-cells in the adult: normal values and levels in individuals with hereditary and acquired elevations of Hb F

Wood, W. G., Stamatoyannopoulos, G., Lim, G., & Nute, P. E. (1975) · Blood · doi:10.1182/blood.v46.5.671.671 · Cited by 247 · see citing works

Fetal Hemoglobin Restriction to a Few Erythrocytes (F Cells) in Normal Human Adults

Boyer, S. H., Belding, T. K., Margolet, L., & Noyes, A. N. (1975) · Science · doi:10.1126/science.804182 · Cited by 237 · see citing works

β-globin Gene Switching and DNase I Sensitivity of the Endogenous β-globin Locus in Mice Do Not Require the Locus Control Region

Bender, M. A., Bulger, M., Close, J., & Groudine, M. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80433-5 · Cited by 224 · see citing works

Augmentation of Fetal-Hemoglobin Production in Anemic Monkeys by Hydroxyurea

Letvin, N. L., Linch, D. C., Beardsley, G. P., McIntyre, K. W., & Nathan, D. G. (1984) · New England Journal of Medicine · doi:10.1056/nejm198404053101401 · Cited by 218 · see citing works

Hemoglobin F synthesis in vitro: evidence for control at the level of primitive erythroid stem cells.

PAPAYANNOPOULOU, T., Brice, M. C., & Stamatoyannopoulos, G. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.7.2923 · Cited by 218 · see citing works

Cellular and molecular regulation of hemoglobin switching

Rowley, P. T. (1980) · Europe PMC (PubMed Central) · Cited by 210 · see citing works

Role of Erythroid Kruppel-like Factor in Human γ- to β-Globin Gene Switching

Donze, D., Townes, T. M., & Bieker, J. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.4.1955 · Cited by 203 · see citing works

Hydroxyurea-induced augmentation of fetal hemoglobin production in patients with sickle cell anemia

Charache, S., Dover, G. J., Moyer, M. A., & Jw, M. (1987) · Blood · doi:10.1182/blood.v69.1.109.109 · Cited by 203 · see citing works

Transcription of the hypersensitive site HS2 enhancer in erythroid cells.

Tuan, D. Y. H., Kong, S., & Hu, K. Q. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11219 · Cited by 196 · see citing works

Human fetal to adult hemoglobin switching: changes in chromatin structure of the beta-globin gene locus.

Groudine, M. T., Kohwi-shigematsu, T., Gelinas, R. E., Stamatoyannopoulos, G., & PAPAYANNOPOULOU, T. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.24.7551 · Cited by 190 · see citing works

G to A substitution in the distal CCAAT box of the Aγ-globin gene in Greek hereditary persistence of fetal haemoglobin

Gelinas, R. E., Endlich, B., Pfeiffer, C., Yagi, M., & Stamatoyannopoulos, G. (1985) · Nature · doi:10.1038/313323a0 · Cited by 188 · see citing works

Human γ-globin genes silenced independently of other genes in the β-globin locus

Dillon, N., & Grosveld, F. G. (1991) · Nature · doi:10.1038/350252a0 · Cited by 187 · see citing works

A point mutation in the Aγ-globin gene promoter in Greek hereditary persistence of fetal haemoglobin

Collins, F. S., Metherall, J. E., Yamakawa, M., Pan, J., Weissman, S. M., & Forget, B. G. (1985) · Nature · doi:10.1038/313325a0 · Cited by 182 · see citing works

Activation of the beta-globin locus control region precedes commitment to the erythroid lineage.

Jiménez, G., Griffiths, S. D., Ford, A. M., Greaves, M. F., & Enver, T. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10618 · Cited by 157 · see citing works

Stimulation of F-Cell Production in Patients with Sickle-Cell Anemia Treated with Cytarabine or Hydroxyurea

Veith, R. W., Galanello, R., Papayannopoulou, T., & Stamatoyannopoulos, G. (1985) · New England Journal of Medicine · doi:10.1056/nejm198512193132503 · Cited by 155 · see citing works

Autonomous Developmental Control of Human Embryonic Globin Gene Switching in Transgenic Mice

Raich, N., Enver, T., Nakamoto, B., Josephson, B. M., Papayannopoulou, T., & Stamatoyannopoulos, G. (1990) · Science · doi:10.1126/science.2251502 · Cited by 143 · see citing works

Activation by locus control regions?

Grosveld, F. G. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80023-9 · Cited by 143 · see citing works

Stimulation of Fetal Hemoglobin Synthesis by Erythropoietin in Baboons

Al-Khatti, A. A., Veith, R. W., Papayannopoulou, T., Fritsch, E. F., Goldwasser, E., & Stamatoyannopoulos, G. (1987) · New England Journal of Medicine · doi:10.1056/nejm198708133170704 · Cited by 143 · see citing works

GATA1 and YY1 are developmental repressors of the human epsilon‐globin gene.

Raich, N., Clegg, C. H., Grofti, J., Roméo, P., & Stamatoyannopoulos, G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07058.x · Cited by 133 · see citing works

G gamma beta+ hereditary persistence of fetal hemoglobin: cosmid cloning and identification of a specific mutation 5' to the G gamma gene.

Collins, F. S., Stoeckert, C. J., Serjeant, G. R., Forget, B. G., & Weissman, S. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.15.4894 · Cited by 131 · see citing works

Stimulation of fetal hemoglobin synthesis in bone marrow cultures from adult individuals.

Papayannopoulou, T., Brice, M. C., & Stamatoyannopoulos, G. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.6.2033 · Cited by 124 · see citing works

Arabinosylcytosine Induces Fetal Hemoglobin in Baboons by Perturbing Erythroid Cell Differentiation Kinetics

Papayannopoulou, T., de Ron, A. T. T., Veith, R. W., Knitter, G. H., & Stamatoyannopoulos, G. (1984) · Science · doi:10.1126/science.6200940 · Cited by 116 · see citing works

Hereditary Persistence of Fetal Hemoglobin in Greece. A Study and a Comparison

Fessas, P., & Stamatoyannopoulos, G. (1964) · Blood · doi:10.1182/blood.v24.3.223.223 · Cited by 114 · see citing works

Use of yeast artificial chromosomes (YACs) in studies of mammalian development: production of beta-globin locus YAC mice carrying human globin developmental mutants.

Peterson, K. R., Li, Q. L., Clegg, C. H., Furukawa, T., Navas, P. A., Norton, E. J., Kimbrough, T. G., & Stamatoyannopoulos, G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5655 · Cited by 114 · see citing works

An embryonic/fetal β‐type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer

Tanabe, O., Katsuoka, F., Campbell, A., Song, W., Yamamoto, M. P., Tanimoto, K., & Engel, J. D. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf340 · Cited by 113 · see citing works

Fetal Hb Production during Acute Erythroid Expansion: I. OBSERVATIONS IN PATIENTS WITH TRANSIENT ERYTHROBLASTOPENIA AND POST‐PHLEBOTOMY

PAPAYANNOPOULOU, T., Vichinsky, E. P., & Stamatoyannopoulos, G. (1980) · British Journal of Haematology · doi:10.1111/j.1365-2141.1980.tb08707.x · Cited by 112 · see citing works

FKLF, a Novel Krüppel-Like Factor That Activates Human Embryonic and Fetal β-Like Globin Genes

Asano, H., Li, X. S., & Stamatoyannopoulos, G. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3571 · Cited by 105 · see citing works

Selective activation of human β - but not γ-globin gene in human fibroblast × mouse erythroleukaemia cell hybrids

Willing, M. C., Nienhuis, A. W., & Anderson, W. F. (1979) · Nature · doi:10.1038/277534a0 · Cited by 99 · see citing works

Cellular and molecular regulation of hemoglobin switching

Stamatoyannopoulos, G., & Nienhuis, A. W. (1979) · Medical Entomology and Zoology · Cited by 96 · see citing works

Embryonic Red Blood Cell Formation

Ingram, V. M. (1972) · Nature · doi:10.1038/235338a0 · Cited by 94 · see citing works

Stimulation of fetal hemoglobin synthesis in baboons by hemolysis and hypoxia.

DeSimone, J., Biel, S. I., & Heller, P. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.6.2937 · Cited by 94 · see citing works

Developmental regulation of human gamma-globin genes in transgenic mice.

Stamatoyannopoulos, G., Josephson, B. M., Zhang, J. W., & Li, Q. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7636 · Cited by 91 · see citing works

Developmental Specificity of the Interaction between the Locus Control Region and Embryonic or Fetal Globin Genes in Transgenic Mice with an HS3 Core Deletion

Navas, P. A., Peterson, K. R., Li, Q., Skarpidi, E., Rohde, A. D., Shaw, S. E., Clegg, C. H., Asano, H., & Stamatoyannopoulos, G. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4188 · Cited by 88 · see citing works

FKLF-2: a novel Kruppel-like transcriptional factor that activates globin and other erythroid lineage genes

Asano, H., Li, X. S., & Stamatoyannopoulos, G. (2000) · Blood · doi:10.1182/blood.v95.11.3578 · Cited by 83 · see citing works

Analysis of human hemoglobin switching in MEL × human fetal erythroid cell hybrids

Papayannopoulou, T., Brice, M. C., & Stamatoyannopoulos, G. (1986) · Cell · doi:10.1016/0092-8674(86)90667-7 · Cited by 82 · see citing works

Perturbations in the erythroid marrow progenitor cell pools may play a role in the augmentation of HbF by 5-azacytidine

de Ron, A. T. T., Papayannopoulou, T., Knapp, M., Fu, M., Knitter, G. H., & Stamatoyannopoulos, G. (1984) · Blood · doi:10.1182/blood.v63.1.201.bloodjournal631201 · Cited by 80 · see citing works

Demonstration of a human epsilon-globin gene silencer with studies in transgenic mice

Raich, N., Papayannopoulou, T., Stamatoyannopoulos, G., & Enver, T. (1992) · Blood · doi:10.1182/blood.v79.4.861.861 · Cited by 80 · see citing works

A MODEL FOR THE PERSISTENCE OR REACTIVATION OF FETAL HqMOGLOBIN PRODUCTION

Weatherall, D. J. (1976) · The Lancet · doi:10.1016/s0140-6736(76)92469-7 · Cited by 77 · see citing works

Context-dependent EKLF responsiveness defines the developmental specificity of the human ɛ-globin gene in erythroid cells of YAC transgenic micePreprint

Tanimoto, K., Liu, Q., Grosveld, F. G., Bungert, J., & Engel, J. D. (2000) · Genes & Development · doi:10.1101/gad.822500 · Cited by 76 · see citing works

Hb F Production in Stressed Erythropoiesis: Observations and Kinetic Modelsaa

Stamatoyannopoulos, G., Veith, R., Galanello, R., & PAPAYANNOPOULOU, T. (1985) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1985.tb17188.x · Cited by 76 · see citing works

The breakpoint of a large deletion causing hereditary persistence of fetal hemoglobin occurs within an erythroid DNA domain remote from the beta-globin gene cluster

Feingold, E., & Forget, B. (1989) · Blood · doi:10.1182/blood.v74.6.2178.2178 · Cited by 70 · see citing works

Production of Erythrocytes that Contain Fetal Hemoglobin in Anemia

Dover, G. J., Boyer, S. H., & Zinkham, W. H. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109286 · Cited by 69 · see citing works

Regulation of embryonic/fetal globin genes by nuclear hormone receptors: a novel perspective on hemoglobin switching

Filipe, A., Li, Q., Deveaux, S., Godin, I., Roméo, P., Stamatoyannopoulos, G., & Mignotte, V. (1999) · The EMBO Journal · doi:10.1093/emboj/18.3.687 · Cited by 69 · see citing works

Developmental Silencing of the Embryonic ζ-Globin Gene: Concerted Action of the Promoter and the 3′-Flanking Region Combined with Stage-Specific Silencing by the Transcribed Segment

Liebhaber, S. A., Wang, Z., Cash, F. E., Monks, B. R., & Russell, J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.6.2637 · Cited by 63 · see citing works

Demonstration of a human epsilon-globin gene silencer with studies in transgenic mice

Raich, N., Papayannopoulou, T., Stamatoyannopoulos, G., et al. (1992) · Blood · doi:10.1182/blood.v79.4.861.bloodjournal794861 · Cited by 53 · see citing works

Sequences Located 3′ to the Breakpoint of the Hereditary Persistence of Fetal Hemoglobin-3 Deletion Exhibit Enhancer Activity and Can Modify the Developmental Expression of the Human Fetal Aγ-Globin Gene in Transgenic Mice

Anagnou, N. P., Perez‐Stable, C., Gelinas, G., Costantini, C., Liapaki, L., Constantopoulou, C., Kosteas, K., Moschonas, N. Κ., & Stamatoyannopoulos, G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.17.10256 · Cited by 49 · see citing works

Treatment of baboon with vinblastine: insights into the mechanisms of pharmacologic stimulation of Hb F in the adult

Veith, R. C., Papayannopoulou, T., Kurachi, S., & Stamatoyannopoulos, G. (1985) · Blood · doi:10.1182/blood.v66.2.456.456 · Cited by 46 · see citing works

Use of yeast artificial chromosomes (YACs) for studying control of gene expression: correct regulation of the genes of a human beta-globin locus YAC following transfer to mouse erythroleukemia cell lines.

Peterson, K. R., Zitnik, G., Huxley, C. M., Lowrey, C. H., Gnirke, A., Leppig, K. A., Papayannopoulou, T., & Stamatoyannopoulos, G. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11207 · Cited by 46 · see citing works

Persistent γ-globin expression in adult transgenic mice is mediated by HPFH-2, HPFH-3, and HPFH-6 breakpoint sequences

Katsantoni, E. Z., Langeveld, A., Wai, A., Drabek, D., Grosveld, F. G., Anagnou, N. P., & Strouboulis, J. (2003) · Blood · doi:10.1182/blood-2003-05-1681 · Cited by 46 · see citing works

Evidence that DNase I hypersensitive site 5 of the human beta-globin locus control region functions as a chromosomal insulator in transgenic mice

Li, Q. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.11.2484 · Cited by 39 · see citing works

RESPIRATORY FILTERS IN CLINICAL PRACTICE

Holdcroft, A., Lumley, J., Gaya, H., & Darlow, H. M. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91991-6 · Cited by 39 · see citing works

Mechanism of Hb F stimulation by S-stage compounds. In vitro studies with bone marrow cells exposed to 5-azacytidine, Ara-C, or hydroxyurea.

Galanello, R., Stamatoyannopoulos, G., & Papayannopoulou, T. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113437 · Cited by 37 · see citing works

Globin Gene Switching

Ikuta, T., Papayannopoulou, T., Stamatoyannopoulos, G., & Kan, Y. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.24.14082 · Cited by 35 · see citing works

Cellular Distribution of Hemoglobin F in a Clonal Hemopoietic Stem-Cell Disorder

Papayannopoulou, T., Bunn, H. F., & Stamatoyannopoulos, G. (1978) · New England Journal of Medicine · doi:10.1056/nejm197801122980203 · Cited by 34 · see citing works

High Levels of Human γ-Globin Gene Expression in Adult Mice Carrying a Transgene of Deletion-Type Hereditary Persistence of Fetal Hemoglobin

Arcasoy, M. O., Romana, M., Fabry, M. E., Skarpidi, E., Nagel, R. L., & Forget, B. G. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.2076 · Cited by 34 · see citing works

Correct Function of the Locus Control Region May Require Passage Through a Nonerythroid Cellular Environment

Vassilopoulos, G., Navas, P. A., Skarpidi, E., Peterson, K. R., Lowrey, C. H., Papayannopoulou, T., & Stamatoyannopoulos, G. (1999) · Blood · doi:10.1182/blood.v93.2.703 · Cited by 30 · see citing works

Developmental Regulation of Human γ-Globin Genes in Transgenic Mice

Stamatoyannopoulos, G., Josephson, B. M., Zhang, J., & Li, Q. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7636-7644.1993 · Cited by 30 · see citing works

Evolution of a Fetal Expression Pattern via cis Changes near the γ Globin Gene

TomHon, C., Zhu, W., Millinoff, D., Hayasaka, K., Slightom, J. L., Goodman, M., & Gumucio, D. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.22.14062 · Cited by 28 · see citing works

Hemopoietic lineage commitment decisions: in vivo evidence from a transgenic mouse model harboring μLCR-βpro-LacZ as a transgene

Papayannopoulou, T., Priestley, G. V., Rohde, A. D., Peterson, K. R., & Nakamoto, B. (2000) · Blood · doi:10.1182/blood.v95.4.1274.004k45_1274_1282 · Cited by 25 · see citing works

Multiple ε-Promoter Elements Participate in the Developmental Control of ε-Globin Genes in Transgenic Mice

Li, Q., Blau, C. A., Clegg, C. H., Rohde, A. D., & Stamatoyannopoulos, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17361 · Cited by 23 · see citing works

Only adult hemoglobin is produced in fetal nonerythroid x MEL cell hybrids

Takegawa, S., Brice, M. C., Stamatoyannopoulos, G., & PAPAYANNOPOULOU, T. (1986) · Blood · doi:10.1182/blood.v68.6.1384.1384 · Cited by 21 · see citing works

Fetal hemoglobin synthesis in vivo: direct evidence for control at the level of erythroid progenitors.

Umemura, T., Al-Khatti, A. A., Papayannopoulou, T., & Stamatoyannopoulos, G. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.9278 · Cited by 21 · see citing works

Fetal hemoglobin in polycythemia vera: cellular distribution in 50 unselected patients

Hoffman, R., Papayannopoulou, T., Landaw, S. A., Wasserman, L., DEMARSH, Q. B., Chen, P., & Stamatoyannopoulos, G. (1979) · Blood · doi:10.1182/blood.v53.6.1148.1148 · Cited by 17 · see citing works

Murine erythroleukemia cell line GM979 contains factors that can activate silent chromosomal human gamma-globin genes.

Zitnik, G., Hines, P. C., Stamatoyannopoulos, G., & Papayannopoulou, T. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.6.2530 · Cited by 12 · see citing works

The minimal promoter plays a major role in silencing of the galago γ-globin gene in adult erythropoiesis

Li, Q., Fang, X., Han, H., & Stamatoyannopoulos, G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402594101 · Cited by 9 · see citing works

Mutation of a transcriptional motif of a distant regulatory element reduces the expression of embryonic and fetal globin genes

Navas, P. A. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg319 · Cited by 9 · see citing works

Juxtaposition of the HPFH2 enhancer is not sufficient to reactivate the γ-globin gene in adult erythropoiesis

Xiang, P., Han, H., Barkess, G., Olave, I. A., Fang, X., Yin, W., Stamatoyannopoulos, G., & Li, Q. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi337 · Cited by 6 · see citing works

A Mutation in a GATA-1 Binding Site 5′ to the Gγ-Globin Gene (nt -567, T>G) May Be Associated with Increased Levels of Fetal Hemoglobin.

Luo, H., Mang, D. W. H., Patrinos, G. P., Wu, C. J., Eung, S. H., Pourfarzad, F., Whitacre, J. L., Rosenfield, C. G., Daoust, P. R., Braun, A. D., et al. (2004) · Blood · doi:10.1182/blood.v104.11.500.500 · Cited by 4 · see citing works

Tet-Regulated Expression of Mutant Neutrophil Elastase in HL-60 Cells: A Cellular Model of Severe Congenital Neutropenia.

Aprikyan, A. A. G., & Markosyan, N. A. (2004) · Blood · doi:10.1182/blood.v104.11.1452.1452 · Cited by 1 · see citing works

Juxtaposition of the HPFH2 Enhancer Is Not Sufficient To Reactivate the g-Globin Gene in Adult Erythropoiesis in bYAC Transgenic Mice.

Xiang, P., Ye, X., Han, H., Stafford, M., Stamatoyannopoulos, G., & Li, Q. (2004) · Blood · doi:10.1182/blood.v104.11.1215.1215 · Cited by 1 · see citing works

Chromosome Conformation Capture Carbon Copy (5C): A massively parallel solution for mapping interactions between genomic elementsPreprint

Dostie, J., Richmond, T., Arnaout, R., Selzer, R. R., Lee, W. L., Honan, T., Rubio, E. D., Krumm, A., Lamb, J., Nusbaum, C., et al. (2006) · Genome Research · doi:10.1101/gr.5571506 · Cited by 1,182 · see citing works

Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor <i>BCL11A</i>

Sankaran, V. G., Menne, T. F., Xu, J., Akie, T. E., Lettre, G., Van Handel, B., Mikkola, H. K. A., Hirschhorn, J. N., Cantor, A. B., & Orkin, S. H. (2008) · Science · doi:10.1126/science.1165409 · Cited by 919 · see citing works

Fetal hemoglobin in sickle cell anemia

Akinsheye, I., Alsultan, A., Solovieff, N., Ngo, D., Baldwin, C. T., Sebastiani, P., Chui, D. H. K., & Steinberg, M. H. (2011) · Blood · doi:10.1182/blood-2011-03-325258 · Cited by 553 · see citing works

Primitive and definitive erythropoiesis in mammals

Palis, J. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00003 · Cited by 442 · see citing works

Thalassaemia

Higgs, D. R., Engel, J. D., & Stamatoyannopoulos, G. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60283-3 · Cited by 445 · see citing works

Sickle cell disease: old discoveries, new concepts, and future promise

Frenette, P. S., & Atweh, G. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30920 · Cited by 400 · see citing works

A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition

Traxler, E. A., Yao, Y., Wang, Y.-D., Woodard, K. J., Kurita, R., Nakamura, Y., Hughes, J. R., Hardison, R. C., Blobel, G. A., Li, C., et al. (2016) · Nature Medicine · doi:10.1038/nm.4170 · Cited by 366 · see citing works

Erythropoiesis: Development and DifferentiationPreprint

Dzierzak, E., & Philipsen, S. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011601 · Cited by 388 · see citing works

Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin

Masuda, T., Wang, X., Maeda, M., Canver, M. C., Sher, F., Funnell, A. P. W., Fisher, C., Suciu, M., Martyn, G. E., Norton, L. J., et al. (2016) · Science · doi:10.1126/science.aad3312 · Cited by 373 · see citing works

Hemoglobin research and the origins of molecular medicine

Schechter, A. N. (2008) · Blood · doi:10.1182/blood-2008-04-078188 · Cited by 382 · see citing works

Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6

Xu, J., Sankaran, V. G., Ni, M., Menne, T. F., Puram, R. V., Kim, W., & Orkin, S. H. (2010) · Genes &amp; Development · doi:10.1101/gad.1897310 · Cited by 361 · see citing works

Hydroxyurea for the Treatment of Sickle Cell Anemia

Platt, O. S. (2008) · New England Journal of Medicine · doi:10.1056/nejmct0708272 · Cited by 357 · see citing works

Biologic properties and enucleation of red blood cells from human embryonic stem cells

Lu, S., Feng, Q., Park, J. S., Vida, L. N., Lee, B.-S., Strausbauch, M. A., Wettstein, P. J., Honig, G. R., & Lanza, R. (2008) · Blood · doi:10.1182/blood-2008-05-157198 · Cited by 293 · see citing works

Heme as key regulator of major mammalian cellular functions: Molecular, cellular, and pharmacological aspects

Tsiftsoglou, A. S., Tsamadou, A. I., & Papadopoulou, L. C. (2006) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2005.10.017 · Cited by 281 · see citing works

Control of fetal hemoglobin: new insights emerging from genomics and clinical implications

Thein, S. L., Menzel, S., Lathrop, M., & Garner, C. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp401 · Cited by 250 · see citing works

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A

Xu, J., Bauer, D. E., Kerenyi, M. A., Vo, T. D., Hou, S., Hsu, Y.-J., Yao, H., Trowbridge, J. J., Mandel, G., & Orkin, S. H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303976110 · Cited by 233 · see citing works

A positive role for NLI/Ldb1 in long-range β-globin locus control region function

Song, S.-H., Hou, C., & Dean, A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.025 · Cited by 233 · see citing works

An Overview of Genome Organization and How We Got There: from FISH to Hi-C

Fraser, J., Williamson, I., Bickmore, W. A., & Dostie, J. (2015) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00006-15 · Cited by 218 · see citing works

Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities

Wilber, A. C., Nienhuis, A. W., & Persons, D. A. (2011) · Blood · doi:10.1182/blood-2010-11-316893 · Cited by 217 · see citing works

Advances in the understanding of haemoglobin switching

Sankaran, V. G., Xu, J., & Orkin, S. H. (2010) · British Journal of Haematology · doi:10.1111/j.1365-2141.2010.08105.x · Cited by 216 · see citing works

HBS1L-MYB intergenic variants modulate fetal hemoglobin via long-range MYB enhancers

Stadhouders, R., Aktuna, S., Thongjuea, S., Aghajanirefah, A., Pourfarzad, F., van IJcken, W. F. J., Lenhard, B., Rooks, H., Best, S., Menzel, S., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci71520 · Cited by 210 · see citing works

Molecular basis of β thalassemia and potential therapeutic targets

Thein, S. L. (2017) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2017.06.001 · Cited by 208 · see citing works

Long-range chromosomal interactions and gene regulation

Miele, A., & Dekker, J. (2008) · Molecular BioSystems · doi:10.1039/b803580f · Cited by 198 · see citing works

Discovering the genetics underlying foetal haemoglobin production in adults

Thein, S. L., & Menzel, S. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07650.x · Cited by 200 · see citing works

Erythropoiesis: Model systems, molecular regulators, and developmental programs

Tsiftsoglou, A. S., Vizirianakis, I. S., & Strouboulis, J. (2009) · IUBMB Life · doi:10.1002/iub.226 · Cited by 199 · see citing works

The nucleosome remodeling and deacetylase complex in development and disease

Basta, J., & Rauchman, M. (2015) · Translational Research · doi:10.1016/j.trsl.2014.05.003 · Cited by 191 · see citing works

Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells

Parseval, L. M., Verhelle, D., Glezer, E., Jensen-Pergakes, K., Ferguson, G. D., Corral, L. G., Morris, C. L., Muller, G. W., Brady, H. A., & Chan, K. W. H. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32322 · Cited by 182 · see citing works

cMYB is involved in the regulation of fetal hemoglobin production in adults

Jiang, J., Best, S., Menzel, S., Silver, N., Lai, M. I., Surdulescu, G. L., Spector, T. D., & Thein, S. L. (2006) · Blood · doi:10.1182/blood-2006-01-008912 · Cited by 174 · see citing works

Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders

Bauer, D. E., Kamran, S. C., & Orkin, S. H. (2012) · Blood · doi:10.1182/blood-2012-06-292078 · Cited by 177 · see citing works

Insulators and promoters: closer than we think

Raab, J. R., & Kamakaka, R. T. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2765 · Cited by 171 · see citing works

“Maturational” globin switching in primary primitive erythroid cells

Kingsley, P. D., Malik, J. T., Emerson, R. L., Bushnell, T. P., McGrath, K. E., Bloedorn, L. A., Bulger, M., & Palis, J. (2005) · Blood · doi:10.1182/blood-2005-08-3097 · Cited by 165 · see citing works

Genomic Perspectives of Transcriptional Regulation in Forebrain Development

Nord, A. S., Pattabiraman, K., Visel, A., & Rubenstein, J. L. R. (2015) · Neuron · doi:10.1016/j.neuron.2014.11.011 · Cited by 152 · see citing works

Hemoglobin Is Expressed by Alveolar Epithelial Cells

Newton, D. A., Rao, K. M. K., Dluhy, R. A., & Baatz, J. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509314200 · Cited by 154 · see citing works

Toward clinical therapies using hematopoietic cells derived from human pluripotent stem cells

Kaufman, D. S. (2009) · Blood · doi:10.1182/blood-2009-03-191304 · Cited by 149 · see citing works

Sickle Cell Anemia and Its Phenotypes

Williams, T. N., & Thein, S. L. (2018) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-083117-021320 · Cited by 151 · see citing works

BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations

Basak, A., Hancarova, M., Ulirsch, J. C., Balci, T. B., Trkova, M., Pelisek, M., Vlckova, M., Muzikova, K., Cermak, J., Trka, J., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81163 · Cited by 147 · see citing works

Molecular Basis and Genetic Modifiers of Thalassemia

Mettananda, S., & Higgs, D. R. (2018) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2017.11.003 · Cited by 147 · see citing works

A transient definitive erythroid lineage with unique regulation of the β-globin locus in the mammalian embryo

McGrath, K. E., Frame, J. M., Fromm, G. J., Koniski, A. D., Kingsley, P. D., Little, J. A., Bulger, M., & Palis, J. (2011) · Blood · doi:10.1182/blood-2010-12-325357 · Cited by 144 · see citing works

Hemoglobin switching’s surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.

Bauer, D. E., & Orkin, S. H. (2015) · Current Opinion in Genetics &amp; Development · doi:10.1016/j.gde.2015.08.001 · Cited by 143 · see citing works

Upregulation of Hemoglobin Expression by Oxidative Stress in Hepatocytes and Its Implication in Nonalcoholic Steatohepatitis

Liu, W., Baker, S. S., Baker, R. D., Nowak, N. J., & Zhu, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024363 · Cited by 141 · see citing works

Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR

Ganis, J. J., Hsia, N., Trompouki, E., de Jong, J. L. O., DiBiase, A., Lambert, J. S., Jia, Z., Sabo, P. J., Weaver, M., Sandstrom, R. S., et al. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.03.021 · Cited by 136 · see citing works

Mir-144 selectively regulates embryonic α-hemoglobin synthesis during primitive erythropoiesis

Fu, Y., Du, T., Dong, M., Zhu, K.-Y., Jing, C., Zhang, Y., Wang, L., Fan, H.-B., Chen, Y., Jin, Y., et al. (2008) · Blood · doi:10.1182/blood-2008-08-174854 · Cited by 134 · see citing works

<i>Rb</i> intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis

Sankaran, V. G., Orkin, & Walkley, C. R. (2008) · Genes &amp; Development · doi:10.1101/gad.1627208 · Cited by 133 · see citing works

Fetal hemoglobin in sickle cell anemia: genetic determinants of response to hydroxyurea

Ma, Q., Wyszynski, D. F., Farrell, J. J., Kutlar, A., Farrer, L. A., Baldwin, C. T., & Steinberg, M. H. (2007) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500433 · Cited by 125 · see citing works

A cell stress signaling model of fetal hemoglobin induction: what doesn't kill red blood cells may make them stronger

Mabaera, R., West, R. J., Conine, S. J., Macari, E. R., Boyd, C. D., Engman, C. A., & Lowrey, C. H. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.06.014 · Cited by 123 · see citing works

Sox6 Directly Silences Epsilon Globin Expression in Definitive Erythropoiesis

Yi, Z., Cohen‐Barak, O., Hagiwara, N., Kingsley, P. D., Fuchs, D. A., Erickson, D. T., Epner, E. M., Palis, J., & Brilliant, M. H. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020014 · Cited by 119 · see citing works

Chapter 1 Ontogeny of Erythropoiesis in the Mammalian Embryo

McGrath, K. E., & Palis, J. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(07)00001-4 · Cited by 110 · see citing works

Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth

Kikuchi, K., & Kondo, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603368103 · Cited by 111 · see citing works

Update on fetal hemoglobin gene regulation in hemoglobinopathies

Bauer, D. E., & Orkin, S. H. (2010) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e3283420fd0 · Cited by 107 · see citing works

Novel Hematopoietic Target Genes in the NRF2-Mediated Transcriptional Pathway

Campbell, M. R., Karaca, M., Adamski, K. N., Chorley, B. N., Wang, X., & Bell, D. A. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/120305 · Cited by 107 · see citing works

Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases

Poletti, V., & Mavilio, F. (2021) · Viruses · doi:10.3390/v13081526 · Cited by 105 · see citing works

Induction of Fetal Hemoglobin in the Treatment of Sickle Cell Disease

Fathallah, H., & Atweh, G. F. (2006) · Hematology · doi:10.1182/asheducation-2006.1.58 · Cited by 95 · see citing works

Dual role for the methyltransferase G9a in the maintenance of β-globin gene transcription in adult erythroid cells

Chaturvedi, C.-P., Hosey, A. M., Palii, C. G., Perez‐Iratxeta, C., Nakatani, Y., Ranish, J. A., Dilworth, F. J., & Brand, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906769106 · Cited by 95 · see citing works

Distinctive Signatures of Histone Methylation in Transcribed Coding and Noncoding Human β-Globin Sequences

Kim, A., Kiefer, C. M., & Dean, A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01684-06 · Cited by 95 · see citing works

Αlpha-thalassemia: A practical overview

Musallam, K. M., Cappellini, M. D., Coates, T. D., Kuo, K. H. M., Al-Samkari, H. T., Sheth, S., Viprakasit, V., & Taher, A. T. (2024) · Blood Reviews · doi:10.1016/j.blre.2023.101165 · Cited by 95 · see citing works

BZLF1 Governs CpG-Methylated Chromatin of Epstein-Barr Virus Reversing Epigenetic Repression

Woellmer, A., Arteaga-Salas, J. M., & Hammerschmidt, W. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002902 · Cited by 92 · see citing works

Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells

Amaya, M., Desai, M., Gnanapragasam, M. N., Wang, S. Z., Zu Zhu, S., Williams, D. C., & Ginder, G. D. (2013) · Blood · doi:10.1182/blood-2012-11-466227 · Cited by 102 · see citing works

Molecular therapies in β‐thalassaemia

Quek, L., & Thein, S. L. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06408.x · Cited by 88 · see citing works

The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans

Menzel, S., Jiang, J., Silver, N., Gallagher, J., Cunningham, J., Surdulescu, G. L., Lathrop, M. G., Farrall, M., Spector, T. D., & Thein, S. L. (2007) · Blood · doi:10.1182/blood-2007-05-093419 · Cited by 87 · see citing works

Global distribution of β-thalassemia mutations: An update

Rao, E., Chandraker, S. K., Singh, M. M., & Kumar, R. (2023) · Gene · doi:10.1016/j.gene.2023.148022 · Cited by 85 · see citing works

Fetal haemoglobin induction in sickle cell disease

Paikari, A., & Sheehan, V. (2017) · British Journal of Haematology · doi:10.1111/bjh.15021 · Cited by 87 · see citing works

Regulation of hematopoietic development by ZBTB transcription factors

Maeda, T. (2016) · International Journal of Hematology · doi:10.1007/s12185-016-2035-x · Cited by 85 · see citing works

A zinc-finger transcriptional activator designed to interact with the γ-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblasts

Wilber, A. C., Tschulena, U., Hargrove, P. W., Kim, Y., Persons, D. A., Barbas, C. F., & Nienhuis, A. W. (2010) · Blood · doi:10.1182/blood-2009-08-240556 · Cited by 83 · see citing works

Epigenetics of β-globin gene regulation

Kiefer, C. M., Hou, C., Little, J. A., & Dean, A. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.07.014 · Cited by 81 · see citing works

Developmental- and differentiation-specific patterns of human γ- and β-globin promoter DNA methylation

Mabaera, R., Richardson, C. A., Johnson, K., Hsu, M., Fiering, S., & Lowrey, C. H. (2007) · Blood · doi:10.1182/blood-2007-01-068635 · Cited by 78 · see citing works

Long-range function of an intergenic retrotransposon

Pi, W., Zhu, X., Wu, M., Wang, Y., Fulzele, S., Eroğlu, A., Ling, J., & Tuan, D. Y. H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004139107 · Cited by 79 · see citing works

Molecular Basis and Genetic Modifiers of Thalassemia

Tesio, N., & Bauer, D. E. (2023) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2022.12.001 · Cited by 83 · see citing works

Modulating gene regulation to treat genetic disorders

Matharu, N. K., & Ahituv, N. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0083-7 · Cited by 75 · see citing works

Suppression of Clonal Dominance in Cultured Human Lymphoid Cells by Addition of the cHS4 Insulator to a Lentiviral Vector

Evans‐Galea, M. V., Wielgosz, M. M., Hanawa, H., Srivastava, D. K., & Nienhuis, A. W. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300103 · Cited by 75 · see citing works

Hypoxia alters progression of the erythroid program

Rogers, H. M., Yu, X., Wen, J., Smith, R. D., Fibach, E., & Noguchi, C. T. (2007) · Experimental Hematology · doi:10.1016/j.exphem.2007.08.014 · Cited by 75 · see citing works

Role of epigenetic modifications in normal globin gene regulation and butyrate-mediated induction of fetal hemoglobin

Fathallah, H., Weinberg, R. S., Galperin, Y., Sutton, M., & Atweh, G. F. (2007) · Blood · doi:10.1182/blood-2007-02-076091 · Cited by 73 · see citing works

Cure for thalassemia major – from allogeneic hematopoietic stem cell transplantation to gene therapy

Srivastava, A., & Velayudhan, S. R. (2016) · Haematologica · doi:10.3324/haematol.2015.141200 · Cited by 72 · see citing works

The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis

Bonifer, C. (2007) · Frontiers in bioscience · doi:10.2741/2700 · Cited by 70 · see citing works

Neither DNA hypomethylation nor changes in the kinetics of erythroid differentiation explain 5-azacytidine's ability to induce human fetal hemoglobin

Mabaera, R., Greene, M. R., Richardson, C. A., Conine, S. J., Kozul, C. D., & Lowrey, C. H. (2007) · Blood · doi:10.1182/blood-2007-06-093948 · Cited by 69 · see citing works

Thalassemia: An Overview of 50 Years of Clinical Research

Sankaran, V. G., & Nathan, D. G. (2010) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2010.08.009 · Cited by 67 · see citing works

Transcriptional silencing of fetal hemoglobin by BCL11A

Sankaran, V. G., Xu, J., & Orkin, S. H. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05574.x · Cited by 67 · see citing works

Epigenetic and molecular profiles of erythroid cells after hydroxyurea treatment in sickle cell anemia

Walker, A. L., Steward, S. A., Howard, T. A., Mortier, N. A., Smeltzer, M. P., Wang, Y., & Ware, R. E. (2011) · Blood · doi:10.1182/blood-2011-07-368746 · Cited by 65 · see citing works

Characterization of Adult α- and β-Globin Elevated by Hydrogen Peroxide in Cervical Cancer Cells That Play A Cytoprotective Role Against Oxidative Insults

Li, X., Wu, Z., Wang, Y., Mei, Q., Fu, X., & Han, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054342 · Cited by 64 · see citing works

NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls β-globin and G-CSF receptor expression

Starnes, L. M., Sorrentino, A., Pelosi, E., Ballarino, M., Morsilli, O., Biffoni, M., Santoro, S., Felli, N., Castelli, G., Marchis, M. L. D., et al. (2009) · Blood · doi:10.1182/blood-2008-12-196196 · Cited by 64 · see citing works

Regulation of erythroid differentiation by miR-376a and its targets

Wang, F., Yu, J., Yang, G., Wang, X., & Zhang, J. (2011) · Cell Research · doi:10.1038/cr.2011.79 · Cited by 63 · see citing works

Regulation of the fetal hemoglobin silencing factor BCL11A

Basak, A., & Sankaran, V. G. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13024 · Cited by 63 · see citing works

The Molecular Pathology of β-Thalassemia in Turkey: The Boğaziçi University Experience

Başak, A. N. (2007) · Hemoglobin · doi:10.1080/03630260701296735 · Cited by 62 · see citing works

Ikaros and GATA-1 Combinatorial Effect Is Required for Silencing of Human γ-Globin Genes

Bottardi, S., Ross, J., Bourgoin, V., Fotouhi‐Ardakani, N., Affar, E. B., Trudel, M., & Milot, É. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01523-08 · Cited by 62 · see citing works

Chaperoning erythropoiesis

Weiss, M. J., & dos Santos, C. O. (2008) · Blood · doi:10.1182/blood-2008-09-115238 · Cited by 61 · see citing works

Integrating one-dimensional and three-dimensional maps of genomes

Naumova, N., & Dekker, J. (2010) · Journal of Cell Science · doi:10.1242/jcs.051631 · Cited by 59 · see citing works

Distinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells

Kiefer, C. M., Lee, J., Hou, C., Dale, R. K., Lee, Y. T., Meier, E. R., Miller, J. L., & Dean, A. (2011) · Blood · doi:10.1182/blood-2011-06-363101 · Cited by 59 · see citing works

Fetal hemoglobin in sickle cell anemia: Genetic studies of the Arab-Indian haplotype

Ngo, D., Bae, H. T., Steinberg, M. H., Paola Sebastiani, B., Solovieff, N., Baldwin, C. T., Melista, E., Safaya, S., Farrer, L. A., AlSuliman, A. M., et al. (2013) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2012.12.005 · Cited by 59 · see citing works

Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Naive T Cells

Bunis, D. G., Bronevetsky, Y., Krow‐Lucal, E., Bhakta, N. R., Kim, C. C., Nerella, S., Jones, N. G., Mendoza, V. F., Bryson, Y. J., Gern, J. E., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108573 · Cited by 57 · see citing works

The in Vivo Toxicity of Hydroxyurea Depends on Its Direct Target Catalase

Juul, T., Małolepszy, A., Dybkær, K., Kidmose, R. T., Rasmussen, J. T., Andersen, G. R., Johnsen, H. E., Jørgensen, J.-E., & Andersen, S. U. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.103564 · Cited by 55 · see citing works

Genetic Basis and Genetic Modifiers of β-Thalassemia and Sickle Cell Disease

Thein, S. L. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-7299-9_2 · Cited by 55 · see citing works

Thalassemias: from gene to therapy

Simone, G. D., Quattrocchi, A., Mancini, B., di Masi, A., Nervi, C., & Ascenzi, P. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.101028 · Cited by 55 · see citing works

Dynamics of human hematopoietic stem and progenitor cell differentiation to the erythroid lineage

Schippel, N., & Sharma, S. (2023) · Experimental Hematology · doi:10.1016/j.exphem.2023.05.001 · Cited by 51 · see citing works

Evaluation of Novel Fetal Hemoglobin Inducer Drugs in Treatment of β-Hemoglobinopathy Disorders.

Fard, A. D., Hosseini, S. A., Shahjahani, M., Salari, F., & Jaseb, K. (2013) · Europe PMC (PubMed Central) · Cited by 52 · see citing works

Short-chain fatty acids induce γ-globin gene expression by displacement of a HDAC3-NCoR repressor complex

Mankidy, R., Faller, D. V., Mabaera, R., Lowrey, C. H., Boosalis, M. S., White, G. L., Castañeda, S. A., & Perrine, S. P. (2006) · Blood · doi:10.1182/blood-2005-12-010934 · Cited by 50 · see citing works

The role of Ikaros in human erythroid differentiation

Dijon, M., Bardin, F., Murati, A., Batoz, M., Chabannon, C., & Tonnelle, C. (2007) · Blood · doi:10.1182/blood-2007-07-098202 · Cited by 50 · see citing works

Identification of embryo–fetal cells in celomic fluid using morphological and short‐tandem repeats analysis

Giambona, A., Leto, F., Damiani, G., Jakil, C., Cigna, V., Schillaci, G., Stampone, G., Volpes, A., Allegra, A., Nicolaides, K. H., et al. (2016) · Prenatal Diagnosis · doi:10.1002/pd.4922 · Cited by 49 · see citing works

Fetal hemoglobin regulation in β-thalassemia: heterogeneity, modifiers and therapeutic approaches

Sripichai, O., & Fucharoen, S. (2016) · Expert Review of Hematology · doi:10.1080/17474086.2016.1255142 · Cited by 48 · see citing works

Analysis of epigenetic alterations to chromatin during development

Minard, M. E., Jain, A. K., & Barton, M. C. (2009) · genesis · doi:10.1002/dvg.20534 · Cited by 47 · see citing works

Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing

Funnell, A. P. W., Mak, K. S., Twine, N. A., Pelka, G. J., Norton, L. J., Radziewic, T., Power, M., Wilkins, M. R., Bell-Anderson, K. S., Fraser, S. T., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00074-13 · Cited by 47 · see citing works

Role of the GATA-1/FOG-1/NuRD Pathway in the Expression of Human β-Like Globin Genes

Miccio, A., & Blobel, G. A. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00001-10 · Cited by 46 · see citing works

The Hemoglobin Regulatory Regions

Pace, B. S., & Makala, L. (2012) · Springer eBooks · doi:10.1007/978-1-4614-1683-8_2 · Cited by 2 · see citing works

Regulation of human fetal hemoglobin: new players, new complexities

Bank, A. (2005) · Blood · doi:10.1182/blood-2005-05-2113 · Cited by 211 · see citing works

Review article Regulation of human fetal hemoglobin: new players, new complexities

Bank, A. (2016)

Hemoglobin switching and its clinical implications.

Blau, C., & Stamatoyannopoulos, G. (1994) · PubMed · Cited by 16 · see citing works

Regulation of Human Globin Gene Expression

Charnay, P. (1986) · Springer eBooks · doi:10.1007/978-3-642-73325-3_28