The DOI matches its Crossref record.
MLH1, PMS1, and MSH2 Interactions During the Initiation of DNA Mismatch Repair in Yeast
Abstract
The discovery that mutations in DNA mismatch repair genes can cause hereditary nonpolyposis colorectal cancer has stimulated interest in understanding the mechanism of DNA mismatch repair in eukaryotes. In the yeast Saccharomyces cerevisiae , DNA mismatch repair requires the MSH2, MLH1, and PMS1 proteins. Experiments revealed that the yeast MLH1 and PMS1 proteins physically associate, possibly forming a heterodimer, and that MLH1 and PMS1 act in concert to bind a MSH2-heteroduplex complex containing a G-T mismatch. Thus, MSH2, MLH1, and PMS1 are likely to form a ternary complex during the initiation of eukaryotic DNA mismatch repair.
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Cited by
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden
Chalmers, Z. R., Connelly, C. F., Fabrizio, D., Gay, L., Ali, S. M., Ennis, R., Schrock, A., Campbell, B., Shlien, A., Chmielecki, J., et al. (2017) · Genome Medicine · doi:10.1186/s13073-017-0424-2 · Cited by 3,519
Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
Pâques, F., & Haber, J. E. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.349-404.1999 · Cited by 2,120
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair
Marsischky, G. T., Filosi, N., Kane, M. F., & Kolodner, R. (1996) · Genes & Development · doi:10.1101/gad.10.4.407 · Cited by 581
Self-citationMorrow, D. M., Tagle, D. A., Shiloh, Y., Collins, F. S., & Hieter, P. (1995) · Cell · doi:10.1016/0092-8674(95)90480-8 · Cited by 370
Narayanan, L., Fritzell, J. A., Baker, S. M., Liskay, R. M., & Glazer, P. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3122 · Cited by 152
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Metadata
- Authors
- Prolla, T. A., Pang, Q., Alani, E., Kolodner, R. D., & Liskay, R. M.
- Venue
- Science
- Published
- 1994-08-19
- Volume
- 265
- Issue
- 5175
- Pages
- 1091-1093
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1997038017
- Cited by
- 290
- References
- 0
- FWCI
- 8.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: MLH1, PMS1, and MSH2 Interactions During the Initiation of DNA Mismatch Repair in Yeast. https://app.cochat.ai/papers/10.1126/science.8066446
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- Prolla, T. A., Pang, Q., Alani, E., Kolodner, R. D., & Liskay, R. M. (1994). MLH1, PMS1, and MSH2 Interactions During the Initiation of DNA Mismatch Repair in Yeast. Science. https://doi.org/10.1126/science.8066446
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