TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene, MEC1
Open accessAbstract
Patients with the genetic disorder ataxia telangiectasia (AT) have mutations in the AT mutated (ATM) gene, which is homologous to TEL1 and the checkpoint gene MEC1. A tel1 deletion mutant, unlike a mec1 deletion, is viable and does not exhibit increased sensitivity to DNA-damaging agents. However, increased dosage of TEL1 rescues sensitivity of a mec1 mutant, mec1-1, to DNA-damaging agents and rescues viability of a mec1 disruption. mec1-1 tel1 delta 1 double mutants are synergistically sensitive to DNA-damaging agents, including radiomimetic drugs. These data indicate that TEL1 and MEC1 are functionally related and that functions of the ATM gene are apparently divided between at least two S. cerevisiae homologs.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In budding yeast, Mec1 is the main checkpoint activator after all DNA lesions, while Tel1 is mainly devoted to telomere maintenance; Tel1's redundant checkpoint role appears only without Mec1.
“This separation of tasks is not found in budding yeast, where Mec1 (the ATR homologue) is the main player of checkpoint activation after all kind of DNA lesions, while Tel1 (the ATM homologue) is especially devoted to telomere maintenance. The redundant role of Tel1 in the DNA damage checkpoint is uncovered only in the absence of Mec1 [15,43].”
From Mind the gap: keeping UV lesions in check (2011) · cites this paper as [43]
Cites
Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669 · see citing works
Sikorski, R. S., & Hieter, P. (1989) · Genetics · doi:10.1093/genetics/122.1.19 · Cited by 8,685 · see citing works
Self-citationSherman, F., Fink, G. R., & Hicks, J. B. (1979) · Cold Spring Harbor Laboratory eBooks · Cited by 7,543 · see citing works
Transformation of intact yeast cells treated with alkali cations
Ito, H., Fukuda, Y., Murata, K., & Kimura, A. (1983) · Journal of Bacteriology · doi:10.1128/jb.153.1.163-168.1983 · Cited by 7,518 · see citing works
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · see citing works
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683 · see citing works
Jacob, H. (1988) · Bioelectrochemistry and Bioenergetics · doi:10.1016/0302-4598(88)80052-7 · Cited by 4,911 · see citing works
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047 · see citing works
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
Fishel, R. A., Lescoe, M. K., Rao, M. R. S., Copeland, N. G., Jenkins, N. A., Garber, J. E., Kane, M., & Kolodner, R. D. (1993) · Cell · doi:10.1016/0092-8674(93)90546-3 · Cited by 2,857 · see citing works
A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase
Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785 · see citing works
Self-citationBoeke, J. D., Lacroute, F., & Fink, G. R. (1984) · Molecular and General Genetics MGG · doi:10.1007/bf00330984 · Cited by 2,354 · see citing works
Bootsma, D., & Hoeijmakers, J. H. J. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)81408-9 · Cited by 2,285 · see citing works
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
Leach, F. S., Nicolaides, N. C., Papadopoulos, N., Liu, B., Jen, J., Parsons, R. E., Peltomäki, P., Sistonen, P., Aaltonen, L. A., Nyström, M., et al. (1993) · Cell · doi:10.1016/0092-8674(93)90330-s · Cited by 2,271 · see citing works
A mammalian protein targeted by G1-arresting rapamycin–receptor complex
Brown, E. J., Albers, M. W., Bum Shin, T., ichikawa, K., Keith, C. T., Lane, W. S., & Schreiber, S. L. (1994) · Nature · doi:10.1038/369756a0 · Cited by 2,053 · see citing works
Bronner, C. E., Baker, S. M., Morrison, P. T., Warren, G., Smith, L. G., Lescoe, M. K., Kane, M., Earabino, C., Lipford, J. R., Lindblom, A., et al. (1994) · Nature · doi:10.1038/368258a0 · Cited by 2,050 · see citing works
Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast
Heitman, J., Movva, N. R., & Hall, M. N. (1991) · Science · doi:10.1126/science.1715094 · Cited by 2,010 · see citing works
Mutation of a mutL Homolog in Hereditary Colon Cancer
Papadopoulos, N., Nicolaides, N. C., Wei, Y.-F., Ruben, S. M., Carter, K. C., Rosen, C. A., Haseltine, W. A., Fleischmann, R. D., Fraser, C. M., Adams, M. D., et al. (1994) · Science · doi:10.1126/science.8128251 · Cited by 1,822 · see citing works
Type 1 Neurofibromatosis Gene: Identification of a Large Transcript Disrupted in Three NF1 Patients
Wallace, M. R., Marchuk, D. A., Andersen, L. B., Letcher, R., Odeh, H. M., Saulino, A. M., Fountain, J. W., Brereton, A., Nicholson, J. M., Mitchell, A. L., et al. (1990) · Science · doi:10.1126/science.2134734 · Cited by 1,476 · see citing works
Self-citationA simple and efficient method for direct gene deletion inSaccharomyces cerevisiae
Baudin‐Baillieu, A., Ozier-Kalogéropoulos, O., DENOUEL, A., Lacroute, F., & Cullin, C. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.14.3329 · Cited by 1,268 · see citing works
Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity
Taylor, A. M. R., Harnden, D. G., Arlett, C. F., Harcourt, S. A., Lehmann, A. R., Stevens, S., & Bridges, B. A. (1975) · Nature · doi:10.1038/258427a0 · Cited by 991 · see citing works
Incidence of Cancer in 161 Families Affected by Ataxia–Telangiectasia
Swift, M., Morrell, D., Massey, R. B., & Chase, C. L. (1991) · New England Journal of Medicine · doi:10.1056/nejm199112263252602 · Cited by 934 · see citing works
Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting
Schu, P. V., Takegawa, K., Fry, M., Stack, J. H., Waterfield, M. D., & Emr, S. D. (1993) · Science · doi:10.1126/science.8385367 · Cited by 920 · see citing works
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.
Ballester, R., Marchuk, D., Boguski, M., Saulino, A., Letcher, R., Wigler, M., & Collins, F. (1990) · Cell · doi:10.1016/0092-8674(90)90151-4 · Cited by 847 · see citing works
Self-citationKunz, J., Henríquez, R., Schneider, U., Deuter‐Reinhard, M., Movva, N. R., & Hall, M. N. (1993) · Cell · doi:10.1016/0092-8674(93)90144-f · Cited by 838 · see citing works
Weinert, T. A., Kiser, G. L., & Hartwell, L. H. (1994) · Genes & Development · doi:10.1101/gad.8.6.652 · Cited by 750 · see citing works
Herman, P. K., & Emr, S. D. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.12.6742 · Cited by 449 · see citing works
The incidence and gene frequency of ataxia-telangiectasia in the United States.
The University of North Carolina at Chapel Hill University Libraries (2020) · PubMed · doi:10.17615/bcfp-c504 · Cited by 405 · see citing works
Telomere dynamics in an immortal human cell line.
Murnane, J. P., Sabatier, L., Marder, B. A., & Morgan, W. F. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06822.x · Cited by 381 · see citing works
Greenwell, P. W., Kronmal, S., Porter, S. E., Gassenhuber, J., Obermaier, B., & Petes, T. D. (1995) · Cell · doi:10.1016/0092-8674(95)90479-4 · Cited by 379 · see citing works
Tanaka, K., Nakafuku, M., Satoh, T., Marshall, M. S., Gibbs, W. W., Matsumoto, K., Kaziro, Y., & Toh‐e, A. (1990) · Cell · doi:10.1016/0092-8674(90)90094-u · Cited by 323 · see citing works
Cafferkey, R., Young, P. R., McLaughlin, M. M., Bergsma, D. J., Koltin, Y., Sathe, G. M., Faucette, L. F., Eng, W.-K., Johnson, R. K., & Livi, G. P. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6012-6023.1993 · Cited by 309 · see citing works
Mortality and Cancer Incidence in 263 Patients With Ataxia-Telangiectasia 2
Morrell, D., Cromartie, E., & Michael Swift, M. D. 4. (1986) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/77.1.89 · Cited by 307 · see citing works
MLH1, PMS1, and MSH2 Interactions During the Initiation of DNA Mismatch Repair in Yeast
Prolla, T. A., Pang, Q., Alani, E., Kolodner, R. D., & Liskay, R. M. (1994) · Science · doi:10.1126/science.8066446 · Cited by 290 · see citing works
Complete DNA sequence of yeast chromosome II.
Feldmann, H., Aigle, M., Aljinovic, G., André, B., Baclet, M. C., Barthe, C., Baur, A., Bécam, A. ‐., Biteau, N., & Boles, E. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06923.x · Cited by 251 · see citing works
Identification of yeast mutants with altered telomere structure.
Lustig, A. J., & Petes, T. D. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.5.1398 · Cited by 249 · see citing works
High Spontaneous Intrachromosomal Recombination Rates in Ataxia-Telangiectasia
Meyn, M. S. (1993) · Science · doi:10.1126/science.8493577 · Cited by 237 · see citing works
Reenan, R. A., & Kolodner, R. D. (1992) · Genetics · doi:10.1093/genetics/132.4.963 · Cited by 220 · see citing works
Kato, R., & Ogawa, H. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.15.3104 · Cited by 218 · see citing works
Ataxia-telangiectasia: an inherited disorder of ionizing-radiation sensitivity in man
McKinnon, P. J. (1987) · Human Genetics · doi:10.1007/bf00281059 · Cited by 200 · see citing works
Taylor, A. M. R. (1987) · Journal of Medical Genetics · doi:10.1136/jmg.24.5.317-a · Cited by 186 · see citing works
Structure, regulation and function of phosphoinositide 3-kinases
Fry, M. (1994) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(94)90036-1 · Cited by 182 · see citing works
Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells
Pandita, T. K., Pathak, S., & Geard, C. R. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000134069 · Cited by 166 · see citing works
Ataxia-Telangiectasia: Closer to Unraveling the Mystery
Shiloh, Y. (1995) · European Journal of Human Genetics · doi:10.1159/000472285 · Cited by 159 · see citing works
Self-citationUnusual sensitivity of ataxia telangiectasia cells to bleomycin.
Taylor, A. M., Rosney, C. M., & Campbell, J. B. (1979) · PubMed · Cited by 148 · see citing works
Schwartz, S. (1987) · Europe PMC (PubMed Central) · Cited by 142 · see citing works
PXA1, a possible Saccharomyces cerevisiae ortholog of the human adrenoleukodystrophy gene.
Shani, N., Watkins, P. A., & Valle, D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.13.6012 · Cited by 129 · see citing works
Shiloh, Y., Tabor, E., & Becker, Y. (1983) · Carcinogenesis · doi:10.1093/carcin/4.10.1317 · Cited by 111 · see citing works
Self-citationThe response of ataxia telangiectasia cells to bleomycin
Lehmam, A. R., & Stevens, S. (1979) · Nucleic Acids Research · doi:10.1093/nar/6.5.1953 · Cited by 78 · see citing works
Seaton, B. L., Yucel, J. K., Sunnerhagen, P., & Subramani, S. E. (1992) · Gene · doi:10.1016/0378-1119(92)90069-2 · Cited by 77 · see citing works
Mechanisms of Chemical Carcinogenesis
Rabin, B. R. (1983) · FEBS Letters · doi:10.1016/0014-5793(83)81084-9 · Cited by 48 · see citing works
Vitamins and cancer prevention: Issues and dilemmas
Young, V. R., & Newberne, P. M. (1981) · Cancer · doi:10.1002/1097-0142(19810301)47:5+ · Cited by 43 · see citing works
Effects of the DNA strand-cleaving antitumor agent, streptonigrin, on ataxia telangiectasia cells.
Taylor, A. M. R., Flude, E., Garner, C. M., Campbell, J. B., & Edwards, M. J. (1983) · PubMed · Cited by 21 · see citing works
Altered DNA synthesis in irradiated and unirradiated ataxia-telangiectasia cells.
Painter, R. B. (1985) · PubMed · Cited by 15 · see citing works
Two forms of Inhibition of DNA replicon initiation in human cells
Painter, R. B., Cramer, P., Howard, R., & Young, B. R. (1981) · University of North Texas Digital Library (University of North Texas) · Cited by 6 · see citing works
Flagged first, then by citations
4 of the 58 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M., & Bonner, W. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00610-2 · Cited by 2,098 · see citing works
Cell Cycle Checkpoints: Preventing an Identity Crisis
Elledge, S. J. (1996) · Science · doi:10.1126/science.274.5293.1664 · Cited by 2,047 · see citing works
ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
Blackford, A. N., & Jackson, S. P. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.05.015 · Cited by 1,953 · see citing works
H2AX: the histone guardian of the genome
Fernández-Capetillo, Ó., Lee, A., Nussenzweig, M. C., & Nussenzweig, A. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.024 · Cited by 1,001 · see citing works
Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair
Symington, L. S. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.4.630-670.2002 · Cited by 965 · see citing works
<i>ATR</i> disruption leads to chromosomal fragmentation and early embryonic lethality
Brown, E. J., & Baltimore, D. (2000) · Genes & Development · doi:10.1101/gad.14.4.397 · Cited by 951 · see citing works
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900 · see citing works
The DNA-dependent protein kinasePreprint
Smith, G. C. M., & Jackson, S. P. (1999) · Genes & Development · doi:10.1101/gad.13.8.916 · Cited by 883 · see citing works
ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin
Goodarzi, A. A., Noon, A. T., Deckbar, D., Ziv, Y., Shiloh, Y., Löbrich, M., & Jeggo, P. A. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.017 · Cited by 836 · see citing works
Self-citationXu, Y., Ashley, T., Brainerd, E. E., Bronson, R. T., Meyn, M. S., & Baltimore, D. (1996) · Genes & Development · doi:10.1101/gad.10.19.2411 · Cited by 830 · see citing works
The many substrates and functions of ATM.
Kastan, M. B., & Lim, D.-S. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35043058 · Cited by 779 · see citing works
Zhao, X., Muller, E. G. D., & Rothstein, R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80277-4 · Cited by 728 · see citing works
THE GENETIC DEFECT IN ATAXIA-TELANGIECTASIA
Lavin, M. F., & Shiloh, Y. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.177 · Cited by 642 · see citing works
Self-citationGADD45 induction of a G <sub>2</sub> /M cell cycle checkpoint
Wang, X. W., Zhan, Q., Coursen, J. D., Khan, M. A., Kontny, H. U., Yu, L., Hollander, M. C., O’Connor, P. M., Fornace, A. J., & Harris, C. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3706 · Cited by 634 · see citing works
Cellular Responses to DNA Damage
Norbury, C. J., & Hickson, I. D. (2001) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.367 · Cited by 628 · see citing works
Sanchez, Y., Desany, B. A., Jones, W. J., Liu, Q., Wang, B., & Elledge, S. J. (1996) · Science · doi:10.1126/science.271.5247.357 · Cited by 585 · see citing works
Paulovich, A. G., & Hartwell, L. H. (1995) · Cell · doi:10.1016/0092-8674(95)90481-6 · Cited by 588 · see citing works
Gasch, A. P., Huang, M., Metzner, S., Botstein, D., Elledge, S. J., & Brown, P. O. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.10.2987 · Cited by 542 · see citing works
Cliby, W. A., Roberts, C. J., Cimprich, K. A., Stringer, C. M., Lamb, J. R., Schreiber, S. L., & Friend, S. H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.159 · Cited by 534 · see citing works
PIK-Related Kinases: DNA Repair, Recombination, and Cell Cycle Checkpoints
Keith, C. T., & Schreiber, S. L. (1995) · Science · doi:10.1126/science.270.5233.50 · Cited by 521 · see citing works
Distribution and Dynamics of Chromatin Modification Induced by a Defined DNA Double-Strand Break
Shroff, R., Arbel‐Eden, A., Pilch, D. R., Ira, G., Bonner, W. M., Petrini, J. H. J., Haber, J. E., & Lichten, M. (2004) · Current Biology · doi:10.1016/j.cub.2004.09.047 · Cited by 499 · see citing works
ATAXIA-TELANGIECTASIA AND THE NIJMEGEN BREAKAGE SYNDROME: Related Disorders But Genes Apart
Shiloh, Y. (1997) · Annual Review of Genetics · doi:10.1146/annurev.genet.31.1.635 · Cited by 482 · see citing works
Self-citationPaull, T. T. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034335 · Cited by 458 · see citing works
Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathwayPreprint
Desany, B. A., Alcasabas, A. A., Bachant, J. B., & Elledge, S. J. (1998) · Genes & Development · doi:10.1101/gad.12.18.2956 · Cited by 448 · see citing works
Skibbens, R. V., Corson, L., Koshland, D. E., & Hieter, P. (1999) · Genes & Development · doi:10.1101/gad.13.3.307 · Cited by 437 · see citing works
Self-citationRegulation of Chromosome Replication
Kelly, T. J., & Brown, G. W. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.829 · Cited by 399 · see citing works
Characterization of the CHD family of proteins
Woodage, T., Basrai, M. A., Baxevanis, A. D., Hieter, P., & Collins, F. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11472 · Cited by 392 · see citing works
Self-citationGreenwell, P. W., Kronmal, S., Porter, S. E., Gassenhuber, J., Obermaier, B., & Petes, T. D. (1995) · Cell · doi:10.1016/0092-8674(95)90479-4 · Cited by 379 · see citing works
A DNA Damage Response Pathway Controlled by Tel1 and the Mre11 Complex
Usui, T., Ogawa, H., & Petrini, J. H. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00270-2 · Cited by 384 · see citing works
Telomerase-Mediated Telomere Addition In Vivo Requires DNA Primase and DNA Polymerases α and δ
Diede, S. J., & Gottschling, D. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81670-0 · Cited by 379 · see citing works
van der Burgt, I., Chrzańowska, K., Smeets, D. F. C. M., & Weemaes, C. (1996) · Journal of Medical Genetics · doi:10.1136/jmg.33.2.153 · Cited by 377 · see citing works
Kalchman, M. A., Koide, H., McCutcheon, K. M., Graham, R. K., Nichol, K., Nishiyama, K., Kazemi‐Esfarjani, P., Lynn, F. C., Wellington, C. L., Metzler, M., et al. (1997) · Nature Genetics · doi:10.1038/ng0597-44 · Cited by 378 · see citing works
The Schizosaccharomyces pombe rad3 checkpoint gene.
Bentley, N. J., Holtzman, D. A., Flaggs, G., Keegan, K. S., DeMaggio, A. J., Ford, J. C., Hoekstra, M. F., & Carr, A. M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01054.x · Cited by 366 · see citing works
Everything You Ever Wanted to Know About Saccharomyces cerevisiae Telomeres: Beginning to End
Wellinger, R. J., & Zakian, V. A. (2012) · Genetics · doi:10.1534/genetics.111.137851 · Cited by 346 · see citing works
Heterozygous ATM mutations do not contribute to early onset of breast cancer
FitzGerald, M. G., Bean, J. M., Hegde, S. R., Ünsal, H., MacDonald, D. J., Harkin, D. P., Finkelstein, D. M., Isselbacher, K. J., & Haber, D. A. (1997) · Nature Genetics · doi:10.1038/ng0397-307 · Cited by 340 · see citing works
Mills, K. D., Sinclair, D. A., & Guarente, L. (1999) · Cell · doi:10.1016/s0092-8674(00)80772-2 · Cited by 334 · see citing works
Myung, K., Datta, A., & Kolodner, R. D. (2001) · Cell · doi:10.1016/s0092-8674(01)00227-6 · Cited by 322 · see citing works
When is a lipid kinase not a lipid kinase? When it is a protein kinase
Hunter, T. (1995) · Cell · doi:10.1016/0092-8674(95)90225-2 · Cited by 306 · see citing works
Goodarzi, A. A., Jeggo, P., & Lobrich, M. (2010) · DNA Repair · doi:10.1016/j.dnarep.2010.09.013 · Cited by 305 · see citing works
Sun, Z., Fay, D. S., Marini, F., Foiani, M., & Stern, D. F. (1996) · Genes & Development · doi:10.1101/gad.10.4.395 · Cited by 300 · see citing works
MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans
Ahmed, S. C., & Hodgkin, J. (2000) · Nature · doi:10.1038/35003120 · Cited by 294 · see citing works
Foundations in Cancer Research p53 and ATM: Cell Cycle, Cell Death, and Cancer
Morgan, S. E., & Kastan, M. B. (1997) · Advances in cancer research · doi:10.1016/s0065-230x(08)60095-0 · Cited by 298 · see citing works
ATM: Genome stability, neuronal development, and cancer cross paths
(2001) · Advances in Cancer Research · doi:10.1016/s0065-230x(01)83007-4 · Cited by 299 · see citing works
Self-citationReifsnyder, C., Lowell, J. E., Clarke, A. S., & Pillus, L. (1996) · Nature Genetics · doi:10.1038/ng0996-42 · Cited by 285 · see citing works
ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanismPreprint
Nakada, D., Matsumoto, K., & Sugimoto, K. (2003) · Genes & Development · doi:10.1101/gad.1099003 · Cited by 284 · see citing works
Vialard, J., Gilbert, C. S., Green, C. M., & Lowndes, N. F. (1998) · The EMBO Journal · doi:10.1093/emboj/17.19.5679 · Cited by 284 · see citing works
Keegan, K. S., Holtzman, D. A., Plug, A. W., Christenson, E., Brainerd, E. E., Flaggs, G., Bentley, N. J., Taylor, E. M., Meyn, M. S., Moss, S. B., et al. (1996) · Genes & Development · doi:10.1101/gad.10.19.2423 · Cited by 283 · see citing works
Hari, K. L., Santerre, A., Sekelsky, J. J., McKim, K. S., Boyd, J. B., & Hawley, R. S. (1995) · Cell · doi:10.1016/0092-8674(95)90478-6 · Cited by 278 · see citing works
Mrša, V., Seidl, T. L., Gentzsch, M., & Tanner, W. (1997) · Yeast · doi:10.1002/(sici)1097-0061(19970930)13:12 · Cited by 226 · see citing works
cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.
Cimprich, K. A., Shin, T. B., Keith, C. T., & Schreiber, S. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2850 · Cited by 273 · see citing works
ATM-related genes: What do they tell us about functions of the human gene?
Zakian, V. A. (1995) · Cell · doi:10.1016/0092-8674(95)90463-8 · Cited by 271 · see citing works
Ritchie, K. B., Mallory, J. C., & Petes, T. D. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.6065 · Cited by 265 · see citing works
DNA damage kinase signaling: checkpoint and repair at 30 years
Lanz, M. C., Dibitetto, D., & Smolka, M. B. (2019) · The EMBO Journal · doi:10.15252/embj.2019101801 · Cited by 259 · see citing works
Brown, A. L., Lee, C. H., Schwarz, J. K., Mitiku, N., Piwnica-Worms, H. M., & Chung, J. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3745 · Cited by 260 · see citing works
Porter, S. E., Greenwell, P. W., Ritchie, K. B., & Petes, T. D. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.4.582 · Cited by 243 · see citing works
Circular chromosome formation in a fission yeast mutant defective in two ATM homologues
Naito, T., Matsuura, A., & Ishikawa, F. (1998) · Nature Genetics · doi:10.1038/2517 · Cited by 237 · see citing works
Scholes, D. T., Banerjee, M., Bowen, B., & Curcio, M. J. (2001) · Genetics · doi:10.1093/genetics/159.4.1449 · Cited by 235 · see citing works
The yeast Xrs2 complex functions in S phase checkpoint regulation
D'Amours, D., & Jackson, S. P. (2001) · Genes & Development · doi:10.1101/gad.208701 · Cited by 228 · see citing works
Wright, J. A., Keegan, K. S., Herendeen, D. R., Bentley, N. J., Carr, A. M., Hoekstra, M. F., & Concannon, P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7445 · Cited by 226 · see citing works
MEC1-Dependent Phosphorylation of Rad9p in Response to DNA Damage
Emili, A. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80128-8 · Cited by 218 · see citing works
Tel2 Regulates the Stability of PI3K-Related Protein Kinases
Takai, H., Wang, R. C., Takai, K., Yang, H., & de Lange, T. (2007) · Cell · doi:10.1016/j.cell.2007.10.052 · Cited by 215 · see citing works
Human genetic diseases: a cross-talk between man and yeast
Foury, F. (1997) · Gene · doi:10.1016/s0378-1119(97)00140-6 · Cited by 210 · see citing works
Hall-Jackson, C. A., Cross, D. A. E., MORRICE, N. A., & Smythe, C. (1999) · Oncogene · doi:10.1038/sj.onc.1203077 · Cited by 213 · see citing works
Goytisolo, F. A., Samper, E., Edmonson, S., Taccioli, G. E., & Blasco, M. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.11.3642-3651.2001 · Cited by 199 · see citing works
Cancer Risk and the ATM Gene: a Continuing Debate
Khanna, K. K. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.10.795 · Cited by 198 · see citing works
A Rad3–Rad26 complex responds to DNA damage independently of other checkpoint proteins
Edwards, R. J., Bentley, N. J., & Carr, A. M. (1999) · Nature Cell Biology · doi:10.1038/15623 · Cited by 197 · see citing works
STRUCTURE, FUNCTION, AND REPLICATION OF SACCHAROMYCES CEREVISIAE TELOMERES
Zakian, V. A. (1996) · Annual Review of Genetics · doi:10.1146/annurev.genet.30.1.141 · Cited by 193 · see citing works
DNA damage checkpoints update: getting molecular
Weinert, T. A. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80140-8 · Cited by 192 · see citing works
Gately, D. P., Hittle, J. C., Chan, G. K. T., & Yen, T. J. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.9.2361 · Cited by 191 · see citing works
The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast
Brush, G. S., Morrow, D. M., Hieter, P., & Kelly, T. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.15075 · Cited by 185 · see citing works
Self-citationTsukamoto, Y., Taggart, A. K. P., & Zakian, V. A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00372-4 · Cited by 180 · see citing works
Inositol pyrophosphates: metabolism and signaling
Bennett, M., Onnebo, S. M. N., Azevedo, C., & Saiardi, A. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5446-z · Cited by 173 · see citing works
Ritchie, K. B., & Petes, T. D. (2000) · Genetics · doi:10.1093/genetics/155.1.475 · Cited by 173 · see citing works
DSB repair: the yeast paradigm
Aylon, Y., & Kupiec, M. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.04.013 · Cited by 170 · see citing works
Telomerase and ATM/Tel1p Protect Telomeres from Nonhomologous End Joining
Chan, S. W.-L., & Blackburn, E. H. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00174-6 · Cited by 165 · see citing works
Genetic Regulation of Phospholipid Metabolism: Yeast as a Model Eukaryote
Henry, S. A., & Patton, J. L. (1998) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60826-0 · Cited by 168 · see citing works
Navas, T. A., Sánchez, Y., & Elledge, S. J. (1996) · Genes & Development · doi:10.1101/gad.10.20.2632 · Cited by 167 · see citing works
Mitotic DNA damage and replication checkpoints in yeast
Rhind, N., & Russell, P. R. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80118-x · Cited by 164 · see citing works
DNA-PK: at the cross-roads of biochemistry and genetics
Jeggo, P. A. (1997) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(97)00009-8 · Cited by 166 · see citing works
ATM function and telomere stability
Pandita, T. K. (2002) · Oncogene · doi:10.1038/sj.onc.1205060 · Cited by 164 · see citing works
C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein
Ahmed, S. C., Alpi, A. F., Hengartner, M. O., & Gartner, A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00604-2 · Cited by 160 · see citing works
Fragments of ATM Which Have Dominant-Negative or Complementing Activity
Morgan, S. E., Lovly, C. M., Pandita, T. K., Shiloh, Y., & Kastan, M. B. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.2020 · Cited by 161 · see citing works
Self-citationIonizing radiation activates the ATM kinase throughout the cell cycle
Pandita, T. K., Lieberman, H. B., Lim, D., Dhar, S., Zheng, W., Taya, Y., & Kastan, M. B. (2000) · Oncogene · doi:10.1038/sj.onc.1203444 · Cited by 155 · see citing works
Bassett, D. E., Boguski, M. S., & Hieter, P. (1996) · Nature · doi:10.1038/379589a0 · Cited by 152 · see citing works
Self-citationSidorova, J. M., & Breeden, L. L. (1997) · Genes & Development · doi:10.1101/gad.11.22.3032 · Cited by 150 · see citing works
Mallory, J. C., & Petes, T. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250475697 · Cited by 145 · see citing works
Myung, K., & Kolodner, R. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062702199 · Cited by 143 · see citing works
Synthetic lethality between mutation in Atm and DNA-PK cs during murine embryogenesis
Gurley, K. E., & Kemp, C. J. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00048-3 · Cited by 142 · see citing works
Xia, J., Peng, Y., Mian, S. I., & Lue, N. F. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.14.5196-5207.2000 · Cited by 141 · see citing works
The roles of telomeres and telomerase in cell life span
Counter, C. M. (1996) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/s0165-1110(96)90006-8 · Cited by 140 · see citing works
Alteration of N-Terminal Phosphoesterase Signature Motifs Inactivates Saccharomyces cerevisiae Mre11
Bressan, D. A., Olivares, H. A., Nelms, B. E., & Petrini, J. H. J. (1998) · Genetics · doi:10.1093/genetics/150.2.591 · Cited by 140 · see citing works
Rouse, J. W., & Jackson, S. P. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5801 · Cited by 139 · see citing works
Roush, A. A., Suarez, M., Friedberg, E. C., Radman, M., & Siede, W. (1998) · Molecular and General Genetics MGG · doi:10.1007/s004380050698 · Cited by 135 · see citing works
Eukaryotic DNA damage checkpoint activation in response to double-strand breaks
Finn, K., Lowndes, N. F., & Grenon, M. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0875-3 · Cited by 127 · see citing works
Extra-chromosomal telomeric DNA in cells from Atm-/- mice and patients with ataxia-telangiectasia
Hande, M. P. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.519 · Cited by 125 · see citing works
Becker-Catania, S. G., Chen, G., Hwang, M. J., Wang, Z., Sun, X., Sanal, Ö., Bernatowska, E. A., Chessa, L., Lee, E. Y.-H. P., & Gatti, R. A. (2000) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2000.2998 · Cited by 123 · see citing works
Phosphoproteomics Reveals Distinct Modes of Mec1/ATR Signaling during DNA Replication
de Oliveira, F. M. B., Kim, D.-S., Cussiol, J. R. R., Das, J., Jeong, M. C., Doerfler, L., Schmidt, K. H., Yu, H., & Smolka, M. B. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.01.043 · Cited by 117 · see citing works
Altering telomere structure allows telomerase to act in yeast lacking ATM kinases
Chan, S. W. L., Chang, J. Y., Prescott, J. C., & Blackburn, E. H. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00391-8 · Cited by 119 · see citing works
Baroni, E., Viscardi, V., Cartagena‐Lirola, H., Lucchini, G., & Longhese, M. P. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.10.4151-4165.2004 · Cited by 116 · see citing works
Morrison, A. J., Kim, J., Person, M. D., Highland, J., Xiao, J., Wehr, T. S., Hensley, S. C., Bao, Y., Shen, J., Collins, S. R., et al. (2007) · Cell · doi:10.1016/j.cell.2007.06.010 · Cited by 116 · see citing works
- Authors
- Morrow, D. M., Tagle, D. A., Shiloh, Y., Collins, F. S., & Hieter, P.
- Affiliations
- Johns Hopkins University (US)
- National Institutes of Health (US)
- Tel Aviv University (IL)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1995-09
- Volume
- 82
- Issue
- 5
- Pages
- 831-840
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2028263332
- Cited by
- 370
- References
- 58
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 9 · 2015: 8 · 2014: 6 · 2013: 8 · 2012: 7
- FWCI
- 14.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Energy
- National Institute for Health and Care Research
- Ministerio de Economía y Competitividad
- National Institutes of Health
- National Cancer Institute (CA-16519, P01CA016519)
- National Institute of General Medical Sciences (GM162283)
- National Institute of Neurological Disorders and Stroke (R01NS031763, NS 31763)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Tel1, Mec1, ataxia telangiectasia, ATM gene, DNA damage checkpoint, radiomimetic drugs, dosage compensation, Saccharomyces cerevisiae
- MeSH terms
- Ataxia Telangiectasia, Base Sequence, Bleomycin, Cloning, Molecular, DNA Damage, Fungal Proteins, Gamma Rays, Genes, Fungal, Humans, Hydroxyurea, Molecular Sequence Data, Mutation, Phenotype, Saccharomyces cerevisiae, Streptonigrin, Ultraviolet Rays, Protein Serine-Threonine Kinases, Sequence Homology, Amino Acid, Saccharomyces cerevisiae Proteins, Intracellular Signaling Peptides and Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review