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Dormancy of Inhibitory Interneurons in a Model of Temporal Lobe Epilepsy
Abstract
In humans temporal lobe epilepsy (TLE) is characterized by recurrent seizures, neuronal hyperexcitability, and selective loss of certain neuronal populations in the hippocampus. Animal models of the condition indicate that a diminution of inhibition mediated by gamma-aminobutyric acid (GABA) accounts for the altered function, and it has been hypothesized that the diminution arises because GABAergic basket interneurons are "dormant" as a result of their being disconnected from excitatory inputs. In hippocampal slices, inhibitory postsynaptic potentials (IPSPs) were elicited in CA1 pyramidal cells by activation of basket cells; responses from an animal model of TLE were compared to those from control tissue. IPSPs evoked indirectly by activation of terminals that then excited basket cells were reduced in the epileptic tissue, whereas IPSPs evoked by direct activation of basket cells, when excitatory neurotransmission was blocked, were not different from controls. These results provide support for the "dormant basket cell" hypothesis and have implications for the pathophysiology and treatment of human TLE.
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Cites
Lacaille, J., & Schwartzkroin, P. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-04-01411.1988 · Cited by 270
Cited by
Interneurons of the hippocampus
Freund, T. F., & Buzsáki, G. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1996)6:4<347::aid-hipo1>3.0.co;2-i · Cited by 3,441
Chemistry and Biochemistry of Type 2 Diabetes
Ross, S. A., Gulve, E. A., & Wang, M. (2004) · Chemical Reviews · doi:10.1021/cr0204653 · Cited by 323
Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons
Chang, M. C., Park, J. M., Pelkey, K. A., Grabenstatter, H. L., Xu, D., Linden, D. J., Sutula, T. P., McBain, C. J., & Worley, P. F. (2010) · Nature Neuroscience · doi:10.1038/nn.2621 · Cited by 316
Epilepsy in the Developing Brain: Lessons from the Laboratory and Clinic
Holmes, G. L. (1997) · Epilepsia · doi:10.1111/j.1528-1157.1997.tb01074.x · Cited by 287
Human clinical trails in antiepileptogenesis
Mani, R., Pollard, J., & Dichter, M. A. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.03.010 · Cited by 51
Metadata
- Authors
- Bekenstein, J. W., & Lothman, E. W.
- Venue
- Science
- Published
- 1993-01
- Volume
- 259
- Issue
- 5091
- Pages
- 97-100
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2064685631
- Cited by
- 231
- References
- 1
- FWCI
- 22.81
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
