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Evidence for a Clonal Origin of Methicillin Resistance in Staphylococcus aureus
Abstract
Soon after methicillin was introduced into clinical practice in the early 1960s, resistant strains of Staphylococcus aureus (MRSA) appeared, bearing a newly acquired resistance gene, mecA , that encodes a penicillin binding protein, PBP2a. MRSA have spread throughout the world, and an investigation of the clonality of 472 isolates by DNA hybridization was performed. All 472 isolates could be divided into six temporally ordered mecA hybridization patterns, and three of these were subdivided by the chromomosomal transposon Tn 554 . Each Tn 554 pattern occurred in association with one and only one mecA pattern, suggesting that mecA divergence preceded the acquisition of Tn 554 in all cases and therefore that mecA may have been acquired just once by S. aureus .
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Citations
Cited by
Naimi, T. S. (2003) · JAMA · doi:10.1001/jama.290.22.2976 · Cited by 1,688
Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology
Lakhundi, S., & Zhang, K. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00020-18 · Cited by 1,637
Antimicrobial resistance: the example of Staphylococcus aureus
Lowy, F. D. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18535 · Cited by 1,445
The evolution of Staphylococcus aureus
Deurenberg, R. H., & Stobberingh, E. E. (2008) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2008.07.007 · Cited by 721
The molecular evolution of methicillin-resistant Staphylococcus aureus
Deurenberg, R. H., Vink, C., Kalenic, S., Friedrich, A. W., Bruggeman, C. A., & Stobberingh, E. E. (2007) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2006.01573.x · Cited by 597
Metadata
- Authors
- Kreiswirth, B., Kornblum, J., Arbeit, R. D., Eisner, W., Maslow, J. N., McGeer, A., Low, D. E., & Novick, R. P.
- Venue
- Science
- Published
- 1993-01-08
- Volume
- 259
- Issue
- 5092
- Pages
- 227-230
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2079988639
- Cited by
- 409
- References
- 0
- FWCI
- 24.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Evidence for a Clonal Origin of Methicillin Resistance in Staphylococcus aureus. https://app.cochat.ai/papers/10.1126/science.8093647
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- Kreiswirth, B., Kornblum, J., Arbeit, R. D., Eisner, W., Maslow, J. N., McGeer, A., Low, D. E., & Novick, R. P. (1993). Evidence for a Clonal Origin of Methicillin Resistance in Staphylococcus aureus. Science. https://doi.org/10.1126/science.8093647
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